Detailed information NTG0390378

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: FSA40_RS07065
• Genome accession: NZ_CP044493
• Coordinates: 1427983..1428864 (-)
• Length: 293 a.a.
• NCBI ID: WP_002262935.1
• Uniprot ID: Q8DT59
• Organism: Streptococcus mutans strain MD
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1422983..1433864

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FSA40_RS07040 (FSA40_1416)	vicR	1423877..1424584 (-)	708	WP_002262930.1	response regulator YycF	Regulator
FSA40_RS07045 (FSA40_1417)	-	1424937..1425719 (+)	783	WP_002262931.1	amino acid ABC transporter ATP-binding protein	-
FSA40_RS07050 (FSA40_1418)	-	1425716..1426528 (+)	813	WP_002262932.1	transporter substrate-binding domain-containing protein	-
FSA40_RS07055 (FSA40_1419)	-	1426546..1427250 (+)	705	WP_002264823.1	amino acid ABC transporter permease	-
FSA40_RS07060 (FSA40_1420)	-	1427265..1427915 (+)	651	WP_002279971.1	amino acid ABC transporter permease	-
FSA40_RS07065 (FSA40_1421)	endA	1427983..1428864 (-)	882	WP_002262935.1	DNA/RNA non-specific endonuclease	Machinery gene
FSA40_RS07070 (FSA40_1422)	-	1428906..1429094 (-)	189	WP_002264826.1	DNA-directed RNA polymerase subunit beta	-
FSA40_RS07075 (FSA40_1423)	murA	1429097..1430368 (-)	1272	WP_002262937.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
FSA40_RS07080 (FSA40_1424)	-	1430434..1430667 (-)	234	WP_002285829.1	DUF1146 family protein	-
FSA40_RS07085 (FSA40_1425)	-	1430939..1431355 (-)	417	WP_002262939.1	F0F1 ATP synthase subunit epsilon	-
FSA40_RS07090 (FSA40_1426)	atpD	1431369..1432775 (-)	1407	WP_002264827.1	F0F1 ATP synthase subunit beta	-
FSA40_RS07095 (FSA40_1427)	-	1432801..1433679 (-)	879	WP_002262941.1	F0F1 ATP synthase subunit gamma	-

Sequence

Protein

• Length: 293 a.a.
• Molecular weight: 32130.72 Da
• Isoelectric Point: 9.5337

>NTDB_id=390378 FSA40_RS07065 WP_002262935.1 1427983..1428864(-) (endA) [Streptococcus mutans strain MD]
MTRKTNKSQRKQQKLCLSLLAALSVFVCTYIATSDHIADSNPIKQAAQLLTGKNKDILSNGSMSHQATPSQELANTVMTD
AVKNALGRQIEWSGAGSFIINHNKTDLNADVASQPYASNQTKIVQGQTVPTVANALLSKATRQYRNRQETGNGRTNWQPA
GWHQLYDLPGDYDHAVDRGHLLAYALVGGLKRFDASTSNPQNVATQAAWANEANSSNSRGQNYYETLIRKALDSHKRVRY
RVTLIYDDNNDILASGSHLEAKSSDGSLEFNVFIPNVQSGLTFDYATGQVKAN

Nucleotide

• Length: 882 bp

>NTDB_id=390378 FSA40_RS07065 WP_002262935.1 1427983..1428864(-) (endA) [Streptococcus mutans strain MD]
ATGACTAGAAAAACGAACAAGTCTCAGCGAAAACAGCAAAAATTATGCTTATCTCTCCTTGCTGCTTTGAGCGTATTTGT
TTGTACTTATATTGCAACCAGTGATCATATTGCTGATAGTAACCCTATAAAGCAGGCTGCCCAATTATTGACAGGTAAAA
ACAAGGATATACTTTCAAATGGTTCAATGAGCCATCAAGCGACTCCCAGTCAAGAATTAGCCAATACTGTTATGACGGAT
GCAGTAAAAAATGCCTTGGGTAGACAAATTGAATGGAGTGGTGCAGGTTCTTTCATTATTAATCATAATAAAACTGACCT
TAACGCTGATGTTGCTAGCCAACCGTATGCTAGTAATCAGACCAAAATCGTTCAAGGACAGACAGTACCAACAGTAGCAA
ATGCTTTGTTAAGTAAGGCTACTCGTCAGTACCGAAACCGCCAAGAGACAGGAAATGGCAGGACAAATTGGCAGCCAGCA
GGCTGGCATCAGCTTTATGATTTGCCGGGTGACTATGATCACGCGGTTGATCGTGGACACTTATTGGCTTATGCTTTGGT
TGGTGGTTTGAAACGATTTGATGCTTCAACGAGTAATCCTCAAAATGTAGCAACACAAGCAGCTTGGGCTAATGAAGCCA
ATAGTTCAAACTCAAGGGGACAAAATTATTATGAAACACTGATTAGAAAAGCTTTGGATAGTCATAAGCGTGTTCGTTAT
CGTGTGACTCTTATCTATGATGACAACAATGATATCTTAGCCAGTGGCAGTCATCTAGAAGCCAAATCATCAGATGGCAG
TCTAGAGTTCAATGTCTTTATTCCTAATGTTCAAAGCGGTTTGACCTTTGATTATGCAACAGGACAAGTTAAGGCAAATT
AA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (99-251)

3D structure

• AlphaFold DB: Q8DT59

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	64.103	79.863	0.512
endA	Streptococcus pneumoniae D39	64.103	79.863	0.512
endA	Streptococcus pneumoniae R6	64.103	79.863	0.512
endA	Streptococcus pneumoniae TIGR4	64.103	79.863	0.512