Detailed information NTG0373385

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FO454_RS06410
• Genome accession: NZ_CP041722
• Coordinates: 1360516..1361559 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain SL13
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1355516..1366559

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FO454_RS06385 (FO454_06390)	-	1355806..1357167 (-)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-
FO454_RS06390 (FO454_06395)	-	1357301..1358281 (-)	981	WP_002477959.1	FUSC family protein	-
FO454_RS06395 (FO454_06400)	map	1358526..1359281 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
FO454_RS06400 (FO454_06405)	-	1359407..1359793 (+)	387	WP_002477960.1	hypothetical protein	-
FO454_RS06405 (FO454_06410)	liaF	1359818..1360519 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
FO454_RS06410 (FO454_06415)	vraS	1360516..1361559 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
FO454_RS06415 (FO454_06420)	vraR	1361549..1362178 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
FO454_RS06420 (FO454_06425)	-	1362351..1363580 (-)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
FO454_RS06425 (FO454_06430)	-	1363783..1364067 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
FO454_RS06430 (FO454_06435)	-	1364074..1364538 (-)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
FO454_RS06435 (FO454_06440)	-	1364702..1364887 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
FO454_RS06440 (FO454_06445)	-	1364957..1366138 (+)	1182	WP_230454756.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=373385 FO454_RS06410 WP_002461334.1 1360516..1361559(+) (vraS) [Staphylococcus lugdunensis strain SL13]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=373385 FO454_RS06410 WP_002461334.1 1360516..1361559(+) (vraS) [Staphylococcus lugdunensis strain SL13]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCGCTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911