Detailed information NTG0358685

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E8M03_RS10135
• Genome accession: NZ_CP039448
• Coordinates: 2013274..2014317 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain VGC1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2008274..2019317

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E8M03_RS10105 (E8M03_10205)	-	2008695..2009951 (-)	1257	WP_078065149.1	aminopeptidase	-
E8M03_RS10110 (E8M03_10210)	-	2009954..2010154 (-)	201	WP_000180460.1	DUF1128 family protein	-
E8M03_RS10115 (E8M03_10215)	-	2010301..2010765 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E8M03_RS10120 (E8M03_10220)	-	2010772..2011047 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E8M03_RS10125 (E8M03_10225)	-	2011325..2012542 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
E8M03_RS10130 (E8M03_10230)	vraR	2012655..2013284 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
E8M03_RS10135 (E8M03_10235)	vraS	2013274..2014317 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E8M03_RS10140 (E8M03_10240)	liaF	2014314..2015015 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E8M03_RS10145 (E8M03_10245)	-	2015030..2015416 (-)	387	WP_001110179.1	hypothetical protein	-
E8M03_RS10150 (E8M03_10250)	map	2015633..2016391 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E8M03_RS10155 (E8M03_10255)	-	2016920..2017906 (+)	987	WP_000999708.1	aromatic acid exporter family protein	-
E8M03_RS10165 (E8M03_10265)	-	2018339..2018752 (-)	414	WP_025174552.1	hypothetical protein	-
E8M03_RS10170 (E8M03_10270)	-	2018781..2018891 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=358685 E8M03_RS10135 WP_001017131.1 2013274..2014317(-) (vraS) [Staphylococcus aureus strain VGC1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=358685 E8M03_RS10135 WP_001017131.1 2013274..2014317(-) (vraS) [Staphylococcus aureus strain VGC1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1