Detailed information
Bioinformatically predicted
Overview
| Name | comYH | Type | Machinery gene |
| Locus tag | ES276_RS09710 | Genome accession | NZ_CP038252 |
| Coordinates | 1926384..1927337 (-) | Length | 317 a.a. |
| NCBI ID | WP_000345135.1 | Uniprot ID | A0A2U3RW99 |
| Organism | Streptococcus pneumoniae strain TVO_1901936 | ||
| Function | dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1863587..1937685 | 1926384..1927337 | within | 0 |
Gene organization within MGE regions
Location: 1863587..1937685
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ES276_RS09400 (ES276_10000) | mraY | 1866147..1867127 (-) | 981 | WP_000470785.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| ES276_RS09405 (ES276_10005) | pbp2X | 1867129..1869381 (-) | 2253 | WP_000872275.1 | penicillin-binding protein 2X | - |
| ES276_RS09410 (ES276_10010) | ftsL | 1869385..1869702 (-) | 318 | WP_000818547.1 | cell division protein FtsL | - |
| ES276_RS09415 (ES276_10015) | rsmH | 1869714..1870664 (-) | 951 | WP_000159382.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| ES276_RS09420 (ES276_10020) | - | 1870830..1871024 (+) | 195 | WP_001082472.1 | helix-turn-helix transcriptional regulator | - |
| ES276_RS09425 (ES276_10025) | - | 1871040..1871582 (+) | 543 | WP_000712374.1 | DUF3278 domain-containing protein | - |
| ES276_RS09430 (ES276_10030) | - | 1871593..1871835 (+) | 243 | WP_000711739.1 | hypothetical protein | - |
| ES276_RS09435 (ES276_10035) | - | 1871846..1872181 (+) | 336 | WP_000838121.1 | hypothetical protein | - |
| ES276_RS09440 (ES276_10040) | - | 1872291..1873292 (-) | 1002 | WP_000412453.1 | LacI family DNA-binding transcriptional regulator | - |
| ES276_RS09445 (ES276_10045) | - | 1873352..1875253 (-) | 1902 | WP_000657091.1 | alginate lyase family protein | - |
| ES276_RS09450 (ES276_10050) | yajC | 1875275..1875568 (-) | 294 | WP_000381734.1 | preprotein translocase subunit YajC | - |
| ES276_RS09455 (ES276_10055) | - | 1875568..1876386 (-) | 819 | WP_000148012.1 | PTS system mannose/fructose/sorbose family transporter subunit IID | - |
| ES276_RS09460 (ES276_10060) | - | 1876373..1877152 (-) | 780 | WP_000026610.1 | PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC | - |
| ES276_RS09465 (ES276_10065) | - | 1877167..1877658 (-) | 492 | WP_000178625.1 | PTS system mannose/fructose/N-acetylgalactosamine-transporter subunit IIB | - |
| ES276_RS09470 (ES276_10070) | - | 1877669..1878859 (-) | 1191 | WP_000592948.1 | glycoside hydrolase family 88 protein | - |
| ES276_RS09475 (ES276_10075) | - | 1878871..1879305 (-) | 435 | WP_000706826.1 | PTS sugar transporter subunit IIA | - |
| ES276_RS09480 (ES276_10080) | - | 1879576..1880391 (+) | 816 | WP_000185879.1 | gluconate 5-dehydrogenase | - |
| ES276_RS09485 (ES276_10085) | - | 1880410..1881051 (+) | 642 | WP_000684785.1 | RpiB/LacA/LacB family sugar-phosphate isomerase | - |
| ES276_RS09490 (ES276_10090) | - | 1881082..1882083 (+) | 1002 | WP_000161485.1 | sugar kinase | - |
| ES276_RS09495 (ES276_10095) | - | 1882093..1882722 (+) | 630 | WP_000167294.1 | bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase | - |
| ES276_RS09505 (ES276_10110) | tnpA | 1883110..1883486 (-) | 377 | Protein_1873 | IS200/IS605 family transposase | - |
| ES276_RS09510 (ES276_10115) | - | 1883870..1887070 (-) | 3201 | WP_001193687.1 | LPXTG-anchored hyaluronate lyase | - |
| ES276_RS09515 (ES276_10120) | - | 1887293..1887769 (+) | 477 | WP_000203065.1 | glutathione peroxidase | - |
| ES276_RS09520 (ES276_10125) | - | 1887991..1890204 (-) | 2214 | WP_238092994.1 | glycoside hydrolase family 31 protein | - |
| ES276_RS09525 (ES276_10135) | - | 1890605..1890781 (-) | 177 | WP_000050748.1 | hypothetical protein | - |
| ES276_RS09530 (ES276_10140) | celB | 1891160..1892518 (-) | 1359 | WP_238092995.1 | PTS cellobiose transporter subunit IIC | - |
| ES276_RS09535 (ES276_10145) | - | 1892598..1893104 (-) | 507 | WP_000358307.1 | hypothetical protein | - |
| ES276_RS09540 (ES276_10150) | - | 1893135..1893449 (-) | 315 | WP_001070943.1 | PTS cellobiose transporter subunit IIA | - |
| ES276_RS09545 (ES276_10155) | - | 1893459..1895438 (-) | 1980 | Protein_1881 | BglG family transcription antiterminator | - |
| ES276_RS09550 (ES276_10160) | - | 1895556..1895870 (-) | 315 | WP_001029637.1 | PTS cellobiose transporter subunit IIB | - |
| ES276_RS09555 (ES276_10165) | - | 1896000..1896239 (-) | 240 | WP_000580382.1 | SemiSWEET transporter | - |
| ES276_RS09560 (ES276_10170) | - | 1896291..1897727 (-) | 1437 | WP_000206471.1 | 6-phospho-beta-glucosidase | - |
| ES276_RS09565 (ES276_10175) | - | 1897917..1898255 (-) | 339 | WP_000176382.1 | antibiotic biosynthesis monooxygenase family protein | - |
| ES276_RS09570 (ES276_10185) | - | 1898411..1899257 (-) | 847 | Protein_1886 | IS630 family transposase | - |
| ES276_RS09575 (ES276_10190) | nadC | 1899388..1900260 (-) | 873 | WP_000022748.1 | carboxylating nicotinate-nucleotide diphosphorylase | - |
| ES276_RS09580 (ES276_10195) | - | 1900497..1901807 (+) | 1311 | WP_000581530.1 | SLC13 family permease | - |
| ES276_RS11120 | - | 1901947..1902075 (+) | 129 | WP_001833084.1 | hypothetical protein | - |
| ES276_RS09590 (ES276_10205) | - | 1902173..1902367 (-) | 195 | WP_000676515.1 | ABC transporter ATP-binding protein | - |
| ES276_RS09595 (ES276_10210) | - | 1902826..1903554 (-) | 729 | WP_000105270.1 | GntR family transcriptional regulator | - |
| ES276_RS09600 (ES276_10215) | - | 1903712..1905121 (+) | 1410 | WP_000728302.1 | glycoside hydrolase family 1 protein | - |
| ES276_RS09605 (ES276_10220) | - | 1905139..1906434 (+) | 1296 | WP_000798146.1 | PTS sugar transporter subunit IIC | - |
| ES276_RS09610 (ES276_10225) | - | 1906439..1906747 (+) | 309 | WP_000809624.1 | PTS sugar transporter subunit IIB | - |
| ES276_RS09615 (ES276_10230) | - | 1906744..1907052 (+) | 309 | WP_000134124.1 | PTS lactose/cellobiose transporter subunit IIA | - |
| ES276_RS09620 (ES276_10235) | adhE | 1908038..1910689 (-) | 2652 | WP_000763969.1 | bifunctional acetaldehyde-CoA/alcohol dehydrogenase | - |
| ES276_RS09625 (ES276_10240) | - | 1910989..1911399 (-) | 411 | WP_000429499.1 | MORN repeat-containing protein | - |
| ES276_RS09630 (ES276_10245) | - | 1911401..1911829 (-) | 429 | WP_000737440.1 | low molecular weight protein-tyrosine-phosphatase | - |
| ES276_RS09635 (ES276_10250) | yajC | 1911875..1912174 (-) | 300 | WP_001069051.1 | preprotein translocase subunit YajC | - |
| ES276_RS09640 (ES276_10255) | tkt | 1912291..1914267 (-) | 1977 | WP_000067853.1 | transketolase | - |
| ES276_RS09645 (ES276_10260) | ulaG | 1914381..1915472 (-) | 1092 | WP_001134220.1 | L-ascorbate 6-phosphate lactonase | - |
| ES276_RS09650 (ES276_10265) | - | 1915584..1917257 (-) | 1674 | WP_000242103.1 | transcription antiterminator | - |
| ES276_RS09655 (ES276_10270) | - | 1917436..1918140 (-) | 705 | WP_001077561.1 | L-ribulose-5-phosphate 4-epimerase | - |
| ES276_RS09660 (ES276_10275) | - | 1918142..1919005 (-) | 864 | WP_000252125.1 | L-ribulose-5-phosphate 3-epimerase | - |
| ES276_RS09665 (ES276_10280) | - | 1919009..1919674 (-) | 666 | WP_000166725.1 | 3-keto-L-gulonate-6-phosphate decarboxylase UlaD | - |
| ES276_RS09670 (ES276_10285) | - | 1919691..1920176 (-) | 486 | WP_001049932.1 | PTS sugar transporter subunit IIA | - |
| ES276_RS09675 (ES276_10290) | - | 1920253..1920534 (-) | 282 | WP_000241469.1 | PTS sugar transporter subunit IIB | - |
| ES276_RS09680 (ES276_10295) | - | 1920557..1922014 (-) | 1458 | WP_000454435.1 | PTS ascorbate transporter subunit IIC | - |
| ES276_RS09685 (ES276_10300) | - | 1922145..1922768 (-) | 624 | WP_000932644.1 | hypothetical protein | - |
| ES276_RS09690 (ES276_10305) | jag | 1922819..1923805 (-) | 987 | WP_000260012.1 | RNA-binding cell elongation regulator Jag/EloR | - |
| ES276_RS09695 (ES276_10310) | - | 1923824..1924648 (-) | 825 | WP_000727904.1 | membrane protein insertase YidC | - |
| ES276_RS09700 (ES276_10315) | rnpA | 1924623..1924994 (-) | 372 | WP_000739253.1 | ribonuclease P protein component | - |
| ES276_RS10870 | - | 1925011..1925142 (-) | 132 | WP_000768904.1 | hypothetical protein | - |
| ES276_RS09705 (ES276_10320) | - | 1925143..1926333 (-) | 1191 | WP_000167757.1 | acetate kinase | - |
| ES276_RS09710 (ES276_10325) | comYH | 1926384..1927337 (-) | 954 | WP_000345135.1 | class I SAM-dependent methyltransferase | Machinery gene |
| ES276_RS09715 (ES276_10330) | - | 1927398..1927992 (-) | 595 | Protein_1916 | class I SAM-dependent methyltransferase | - |
| ES276_RS09720 (ES276_10335) | comGG/cglG | 1928129..1928542 (-) | 414 | WP_000265622.1 | competence type IV pilus minor pilin ComGG | Machinery gene |
| ES276_RS09725 (ES276_10340) | comGF/cglF | 1928520..1928981 (-) | 462 | WP_000250534.1 | competence type IV pilus minor pilin ComGF | Machinery gene |
| ES276_RS09730 (ES276_10345) | comGE/cglE | 1928944..1929246 (-) | 303 | WP_000413382.1 | competence type IV pilus minor pilin ComGE | Machinery gene |
| ES276_RS09735 (ES276_10350) | comGD/cglD | 1929209..1929613 (-) | 405 | WP_000588028.1 | competence type IV pilus minor pilin ComGD | Machinery gene |
| ES276_RS09740 (ES276_10355) | comGC/cglC | 1929606..1929932 (-) | 327 | WP_000738627.1 | comG operon protein ComGC | Machinery gene |
| ES276_RS09745 (ES276_10360) | comGB/cglB | 1929934..1930950 (-) | 1017 | WP_074196785.1 | competence type IV pilus assembly protein ComGB | Machinery gene |
| ES276_RS09750 (ES276_10365) | comGA/cglA/cilD | 1930898..1931839 (-) | 942 | WP_000249564.1 | competence type IV pilus ATPase ComGA | Machinery gene |
| ES276_RS09755 (ES276_10370) | - | 1931915..1932280 (-) | 366 | WP_000286415.1 | DUF1033 family protein | - |
| ES276_RS09760 (ES276_10375) | - | 1932431..1933489 (-) | 1059 | WP_000649468.1 | zinc-dependent alcohol dehydrogenase family protein | - |
| ES276_RS09765 (ES276_10380) | nagA | 1933652..1934803 (-) | 1152 | WP_001134457.1 | N-acetylglucosamine-6-phosphate deacetylase | - |
| ES276_RS09770 (ES276_10385) | - | 1934956..1936773 (-) | 1818 | WP_001220855.1 | acyltransferase family protein | - |
Sequence
Protein
Download Length: 317 a.a. Molecular weight: 35756.99 Da Isoelectric Point: 4.2748
>NTDB_id=352650 ES276_RS09710 WP_000345135.1 1926384..1927337(-) (comYH) [Streptococcus pneumoniae strain TVO_1901936]
MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGETELNQVKENNQTLKRLALRKEEWLKTYQFLLMKAGQT
EPLQANHQFTPDAIALLLVFIVEELFKEEEITILEMGSGMGILGAIFLTSLTKKVDYLGMEVDDLLIDLAASMADVIGLQ
AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGLKYLKSDGYAIFLAPSDLLTSPQ
SDLLKEWLKEEASLVAMISLPENLFANAKQSKTIFILQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI
MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGETELNQVKENNQTLKRLALRKEEWLKTYQFLLMKAGQT
EPLQANHQFTPDAIALLLVFIVEELFKEEEITILEMGSGMGILGAIFLTSLTKKVDYLGMEVDDLLIDLAASMADVIGLQ
AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGLKYLKSDGYAIFLAPSDLLTSPQ
SDLLKEWLKEEASLVAMISLPENLFANAKQSKTIFILQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI
Nucleotide
Download Length: 954 bp
>NTDB_id=352650 ES276_RS09710 WP_000345135.1 1926384..1927337(-) (comYH) [Streptococcus pneumoniae strain TVO_1901936]
ATGGATTTTGAAAAAATTGAACAAGCTTATACCTATTTACTAGAGAATGTCCAAGTCATCCAAAGTGATTTGGCGACCAA
CTTTTATGACGCCTTGGTGGAGCAAAATAGCATCTATCTGGATGGTGAAACTGAGCTAAACCAGGTCAAGGAGAACAATC
AAACCCTTAAGCGTTTAGCACTACGCAAAGAAGAATGGCTCAAGACCTACCAGTTTCTCTTGATGAAGGCTGGGCAAACA
GAACCCTTGCAGGCCAATCACCAGTTTACACCGGATGCTATTGCTTTGCTTTTGGTGTTTATTGTGGAAGAGTTGTTTAA
AGAGGAGGAAATTACTATCCTCGAAATGGGTTCTGGGATGGGAATTCTAGGCGCTATTTTCTTGACCTCGCTTACTAAAA
AGGTGGATTACTTGGGAATGGAAGTGGATGATTTGCTGATTGATCTGGCAGCTAGCATGGCAGATGTAATTGGTTTGCAG
GCTGGCTTTGTCCAAGGAGATGCCGTTCGCCCACAAATGCTCAAAGAAAGCGATGTGGTCATCAGTGACTTGCCTGTCGG
CTATTATCCTGATGATGCCGTTGCGTCGCGCCATCAAGTTGCTTCTAGCCAAGAACATACTTACGCCCATCACTTGCTCA
TGGAACAAGGGCTTAAGTACCTCAAGTCAGACGGATACGCTATTTTTCTAGCTCCGAGTGATTTGTTGACCAGTCCTCAA
AGTGATTTGTTAAAAGAATGGCTGAAAGAAGAGGCGAGTCTGGTTGCTATGATTAGTCTGCCTGAAAATCTCTTTGCTAA
TGCCAAACAATCTAAGACTATTTTTATCTTACAGAAGAAAAATGAAATAGCAGTAGAGCCTTTTGTTTATCCACTTGCTA
GCTTGCAAGATGCAAGTGTTTTAATGAAATTTAAAGAAAATTTTCAAAAATGGACTCAAGGTACTGAAATATAA
ATGGATTTTGAAAAAATTGAACAAGCTTATACCTATTTACTAGAGAATGTCCAAGTCATCCAAAGTGATTTGGCGACCAA
CTTTTATGACGCCTTGGTGGAGCAAAATAGCATCTATCTGGATGGTGAAACTGAGCTAAACCAGGTCAAGGAGAACAATC
AAACCCTTAAGCGTTTAGCACTACGCAAAGAAGAATGGCTCAAGACCTACCAGTTTCTCTTGATGAAGGCTGGGCAAACA
GAACCCTTGCAGGCCAATCACCAGTTTACACCGGATGCTATTGCTTTGCTTTTGGTGTTTATTGTGGAAGAGTTGTTTAA
AGAGGAGGAAATTACTATCCTCGAAATGGGTTCTGGGATGGGAATTCTAGGCGCTATTTTCTTGACCTCGCTTACTAAAA
AGGTGGATTACTTGGGAATGGAAGTGGATGATTTGCTGATTGATCTGGCAGCTAGCATGGCAGATGTAATTGGTTTGCAG
GCTGGCTTTGTCCAAGGAGATGCCGTTCGCCCACAAATGCTCAAAGAAAGCGATGTGGTCATCAGTGACTTGCCTGTCGG
CTATTATCCTGATGATGCCGTTGCGTCGCGCCATCAAGTTGCTTCTAGCCAAGAACATACTTACGCCCATCACTTGCTCA
TGGAACAAGGGCTTAAGTACCTCAAGTCAGACGGATACGCTATTTTTCTAGCTCCGAGTGATTTGTTGACCAGTCCTCAA
AGTGATTTGTTAAAAGAATGGCTGAAAGAAGAGGCGAGTCTGGTTGCTATGATTAGTCTGCCTGAAAATCTCTTTGCTAA
TGCCAAACAATCTAAGACTATTTTTATCTTACAGAAGAAAAATGAAATAGCAGTAGAGCCTTTTGTTTATCCACTTGCTA
GCTTGCAAGATGCAAGTGTTTTAATGAAATTTAAAGAAAATTTTCAAAAATGGACTCAAGGTACTGAAATATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comYH | Streptococcus mutans UA140 |
54.633 |
98.738 |
0.539 |
| comYH | Streptococcus mutans UA159 |
54.313 |
98.738 |
0.536 |