Detailed information NTG0350149

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: GKC13_RS01955
• Genome accession: NZ_CP046134
• Coordinates: 364845..365630 (+)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain MAG_rmk202_sterm
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 359845..370630

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GKC13_RS01930 (GKC13_01930)	pflA	360121..360921 (+)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-
GKC13_RS01935 (GKC13_01935)	-	361133..361507 (+)	375	WP_011681547.1	membrane protein	-
GKC13_RS01940	-	361568..361741 (+)	174	WP_011681546.1	hypothetical protein	-
GKC13_RS09860 (GKC13_01940)	-	361813..362387 (-)	575	Protein_375	IS30 family transposase	-
GKC13_RS01945 (GKC13_01945)	-	362564..363016 (-)	453	WP_002946987.1	universal stress protein	-
GKC13_RS01950 (GKC13_01950)	-	363371..364585 (+)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
GKC13_RS01955 (GKC13_01955)	codY	364845..365630 (+)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
GKC13_RS01960 (GKC13_01960)	-	365693..366244 (+)	552	WP_084829819.1	isochorismatase family cysteine hydrolase	-
GKC13_RS01965 (GKC13_01965)	-	366367..367215 (+)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
GKC13_RS01970 (GKC13_01970)	msrA	367227..367736 (+)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
GKC13_RS01975 (GKC13_01975)	-	367889..369333 (+)	1445	Protein_382	6-phospho-beta-glucosidase	-
GKC13_RS01980 (GKC13_01980)	-	369697..369858 (+)	162	WP_224102937.1	glycosyltransferase	-
GKC13_RS01985 (GKC13_01985)	-	369871..370125 (+)	255	WP_095559434.1	glycosyltransferase	-
GKC13_RS01990 (GKC13_01990)	gatC	370265..370567 (+)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=350149 GKC13_RS01955 WP_002951720.1 364845..365630(+) (codY) [Streptococcus thermophilus strain MAG_rmk202_sterm]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=350149 GKC13_RS01955 WP_002951720.1 364845..365630(+) (codY) [Streptococcus thermophilus strain MAG_rmk202_sterm]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502