Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   EQH45_RS02015 Genome accession   NZ_CP035235
Coordinates   394011..394700 (+) Length   229 a.a.
NCBI ID   WP_000518014.1    Uniprot ID   A0A6I3TI70
Organism   Streptococcus pneumoniae strain TVO_1902276     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 389011..399700
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH45_RS01990 (EQH45_02115) gpsB 389120..389449 (+) 330 WP_000146522.1 cell division regulator GpsB -
  EQH45_RS02000 (EQH45_02125) - 389935..391092 (+) 1158 WP_000711377.1 class I SAM-dependent RNA methyltransferase -
  EQH45_RS02005 (EQH45_02130) mapZ 391105..392499 (+) 1395 WP_000039303.1 mid-cell-anchored protein MapZ -
  EQH45_RS02010 (EQH45_02135) gndA 392575..393999 (+) 1425 WP_000158767.1 NADP-dependent phosphogluconate dehydrogenase -
  EQH45_RS02015 (EQH45_02140) covR 394011..394700 (+) 690 WP_000518014.1 response regulator transcription factor Regulator
  EQH45_RS02020 (EQH45_02145) cbpC 394798..395814 (+) 1017 WP_000771089.1 choline-binding protein CbpC -
  EQH45_RS02025 (EQH45_02150) mvk 395936..396814 (+) 879 WP_000163324.1 mevalonate kinase -
  EQH45_RS02030 (EQH45_02155) mvaD 396796..397749 (+) 954 WP_000373457.1 diphosphomevalonate decarboxylase -
  EQH45_RS02035 (EQH45_02160) - 397736..398743 (+) 1008 WP_000562425.1 phosphomevalonate kinase -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26882.22 Da        Isoelectric Point: 6.9836

>NTDB_id=336649 EQH45_RS02015 WP_000518014.1 394011..394700(+) (covR) [Streptococcus pneumoniae strain TVO_1902276]
MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQTDYDLMLLNVNLGDMMAQDFAEKLSRTKPASVIMIL
DHWEDLQEELEVVQRFAVAYIYKPVLIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=336649 EQH45_RS02015 WP_000518014.1 394011..394700(+) (covR) [Streptococcus pneumoniae strain TVO_1902276]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAGAAAGAGCAGTA
TCGGGTTGATCTGGTAGAGGAGGGGCAAAAAGCCCTCTCCATGGCTCTTCAGACAGACTATGATTTGATGTTATTGAACG
TTAATCTGGGAGATATGATGGCTCAGGATTTTGCAGAAAAATTGAGTCGAACTAAACCTGCCTCAGTCATCATGATTTTA
GATCATTGGGAAGACTTGCAAGAAGAGCTGGAAGTTGTTCAGCGTTTTGCAGTTGCATACATTTATAAGCCAGTCCTTAT
CGAAAATCTGGTAGCGCGTATTTCGGCGATCTTCCGAGGTCGGGACTTCATTGATCAACACTGCAGTCTGATGAAAGTTC
CAAGGACTTACCGCAATCTTAGGATAGATGTTGAACATCACACGGTTTATCGTGGTGAAGAGATGATTGCTCTGACCCGC
CGTGAGTATGACCTTTTGGCGACACTTATGGGAAGCAAGAAAGTATTGACTCGTGAGCAATTGTTGGAAAGTGTTTGGAA
GTATGAAAGTGCGACCGAGACAAATATCGTAGATGTCTATATCCGCTATCTACGGAGCAAGCTTGATGTTAAAGGCCAAA
AAAGCTACATTAAAACCGTGCGTGGTGTTGGATATACCATGCAAGAATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-226)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6I3TI70

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

47.826

100

0.48
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.087

100

0.463

Multiple sequence alignment