Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   EQH46_RS09735 Genome accession   NZ_CP035234
Coordinates   1898732..1899673 (-) Length   313 a.a.
NCBI ID   WP_000249568.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1902277     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1893732..1904673
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH46_RS09695 (EQH46_10205) comYH 1894219..1895172 (-) 954 WP_000345086.1 class I SAM-dependent methyltransferase Machinery gene
  EQH46_RS09700 (EQH46_10210) - 1895233..1895827 (-) 595 Protein_1916 class I SAM-dependent methyltransferase -
  EQH46_RS09705 (EQH46_10215) comGG/cglG 1895930..1896376 (-) 447 WP_001811371.1 competence type IV pilus minor pilin ComGG Machinery gene
  EQH46_RS09710 (EQH46_10220) comGF/cglF 1896354..1896815 (-) 462 WP_000250523.1 competence type IV pilus minor pilin ComGF Machinery gene
  EQH46_RS09715 (EQH46_10225) comGE/cglE 1896778..1897080 (-) 303 WP_000413380.1 competence type IV pilus minor pilin ComGE Machinery gene
  EQH46_RS09720 (EQH46_10230) comGD/cglD 1897043..1897447 (-) 405 WP_000588023.1 competence type IV pilus minor pilin ComGD Machinery gene
  EQH46_RS09725 (EQH46_10235) comGC/cglC 1897440..1897766 (-) 327 WP_000738621.1 comG operon protein ComGC Machinery gene
  EQH46_RS09730 (EQH46_10240) comGB/cglB 1897768..1898784 (-) 1017 WP_074017570.1 competence type IV pilus assembly protein ComGB Machinery gene
  EQH46_RS09735 (EQH46_10245) comGA/cglA/cilD 1898732..1899673 (-) 942 WP_000249568.1 competence type IV pilus ATPase ComGA Machinery gene
  EQH46_RS09740 (EQH46_10250) - 1899749..1900114 (-) 366 WP_000286415.1 DUF1033 family protein -
  EQH46_RS09745 (EQH46_10255) - 1900265..1901323 (-) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -
  EQH46_RS09750 (EQH46_10260) nagA 1901486..1902637 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  EQH46_RS09755 (EQH46_10265) - 1902790..1904607 (-) 1818 WP_001220922.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35617.60 Da        Isoelectric Point: 6.0083

>NTDB_id=336626 EQH46_RS09735 WP_000249568.1 1898732..1899673(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain TVO_1902277]
MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDIETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=336626 EQH46_RS09735 WP_000249568.1 1898732..1899673(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain TVO_1902277]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGAAAAAAGGGACGCAGGATATTTATTTTGTCCCTAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGACATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGCCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACATCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae D39

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae R6

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

98.722

100

0.987
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.486

100

0.965
  comYA Streptococcus gordonii str. Challis substr. CH1

77.419

99.042

0.767
  comYA Streptococcus mutans UA159

65.916

99.361

0.655
  comYA Streptococcus mutans UA140

65.916

99.361

0.655
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.581

99.042

0.62
  comGA Lactococcus lactis subsp. cremoris KW2

54.808

99.681

0.546
  comGA Latilactobacillus sakei subsp. sakei 23K

41.912

86.901

0.364

Multiple sequence alignment