Detailed information
Bioinformatically predicted
Overview
| Name | pilH | Type | Machinery gene |
| Locus tag | EGH12_RS07735 | Genome accession | NZ_CP034020 |
| Coordinates | 1319527..1320189 (-) | Length | 220 a.a. |
| NCBI ID | WP_047916986.1 | Uniprot ID | A0AA44U7R7 |
| Organism | Neisseria gonorrhoeae strain FQ48 | ||
| Function | type IV pilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 1265363..1330139 | 1319527..1320189 | within | 0 |
Gene organization within MGE regions
Location: 1265363..1330139
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EGH12_RS07345 (EGH12_07345) | - | 1265363..1266016 (-) | 654 | WP_050157023.1 | IS1595 family transposase | - |
| EGH12_RS07355 (EGH12_07355) | purM | 1267013..1268047 (-) | 1035 | WP_003691398.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| EGH12_RS07365 (EGH12_07365) | - | 1268736..1269725 (+) | 990 | WP_003689040.1 | site-specific integrase | - |
| EGH12_RS07375 (EGH12_07375) | - | 1270067..1270546 (+) | 480 | WP_002241413.1 | DUF4760 domain-containing protein | - |
| EGH12_RS07380 (EGH12_07380) | - | 1270606..1273653 (-) | 3048 | WP_047953556.1 | tape measure protein | - |
| EGH12_RS07385 (EGH12_07385) | - | 1273683..1273832 (-) | 150 | WP_003691402.1 | hypothetical protein | - |
| EGH12_RS07390 (EGH12_07390) | - | 1274144..1274317 (-) | 174 | WP_003705498.1 | hypothetical protein | - |
| EGH12_RS07395 (EGH12_07395) | - | 1274301..1274642 (-) | 342 | WP_003700102.1 | hypothetical protein | - |
| EGH12_RS13485 | - | 1274626..1274784 (-) | 159 | WP_003691816.1 | hypothetical protein | - |
| EGH12_RS07400 (EGH12_07400) | - | 1274784..1275323 (-) | 540 | WP_050153719.1 | TIGR02594 family protein | - |
| EGH12_RS07410 (EGH12_07410) | - | 1275530..1275766 (+) | 237 | WP_003689049.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| EGH12_RS07415 (EGH12_07415) | - | 1275766..1276113 (+) | 348 | WP_003689051.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| EGH12_RS07420 (EGH12_07420) | - | 1276469..1276801 (-) | 333 | WP_003691408.1 | hypothetical protein | - |
| EGH12_RS07425 (EGH12_07425) | - | 1276802..1277272 (-) | 471 | WP_003691410.1 | hypothetical protein | - |
| EGH12_RS07430 (EGH12_07430) | - | 1277343..1277648 (-) | 306 | WP_003689058.1 | hypothetical protein | - |
| EGH12_RS07435 (EGH12_07435) | - | 1277760..1281905 (-) | 4146 | WP_047921483.1 | phage tail protein | - |
| EGH12_RS07440 (EGH12_07440) | - | 1282145..1282423 (+) | 279 | WP_003689062.1 | XRE family transcriptional regulator | - |
| EGH12_RS07445 (EGH12_07445) | - | 1282451..1282882 (-) | 432 | WP_003689064.1 | NlpC/P60 family protein | - |
| EGH12_RS07450 (EGH12_07450) | - | 1282884..1283738 (-) | 855 | WP_003698614.1 | DUF2163 domain-containing protein | - |
| EGH12_RS07455 (EGH12_07455) | - | 1283735..1284334 (-) | 600 | WP_003691415.1 | DUF2460 domain-containing protein | - |
| EGH12_RS07460 (EGH12_07460) | - | 1284334..1284600 (-) | 267 | WP_003689070.1 | hypothetical protein | - |
| EGH12_RS07465 (EGH12_07465) | - | 1284612..1284941 (-) | 330 | WP_003692871.1 | hypothetical protein | - |
| EGH12_RS07470 (EGH12_07470) | - | 1285002..1285775 (-) | 774 | WP_003691416.1 | hypothetical protein | - |
| EGH12_RS07475 (EGH12_07475) | - | 1285801..1286229 (-) | 429 | WP_003689076.1 | hypothetical protein | - |
| EGH12_RS07480 (EGH12_07480) | - | 1286226..1286708 (-) | 483 | WP_044271038.1 | HK97 gp10 family phage protein | - |
| EGH12_RS07485 (EGH12_07485) | - | 1286708..1287238 (-) | 531 | WP_003689080.1 | head-tail connector protein | - |
| EGH12_RS13830 (EGH12_07490) | - | 1287241..1287603 (-) | 363 | WP_003689082.1 | hypothetical protein | - |
| EGH12_RS07495 (EGH12_07495) | - | 1287610..1289109 (-) | 1500 | WP_003691419.1 | hypothetical protein | - |
| EGH12_RS07500 (EGH12_07500) | - | 1289150..1290307 (-) | 1158 | WP_003691421.1 | HK97 family phage prohead protease | - |
| EGH12_RS07505 (EGH12_07505) | - | 1290375..1292522 (-) | 2148 | WP_003691423.1 | phage portal protein | - |
| EGH12_RS07510 (EGH12_07510) | terL | 1292519..1293940 (-) | 1422 | WP_003689090.1 | phage terminase large subunit | - |
| EGH12_RS07515 (EGH12_07515) | - | 1294002..1294451 (-) | 450 | WP_003689093.1 | hypothetical protein | - |
| EGH12_RS07520 (EGH12_07520) | - | 1294744..1295613 (-) | 870 | WP_050153721.1 | Bro-N domain-containing protein | - |
| EGH12_RS07525 (EGH12_07525) | - | 1295894..1297054 (-) | 1161 | WP_047921542.1 | type I restriction endonuclease | - |
| EGH12_RS07530 (EGH12_07530) | - | 1297145..1297552 (-) | 408 | WP_003691430.1 | hypothetical protein | - |
| EGH12_RS14555 | - | 1297674..1297802 (+) | 129 | WP_012503747.1 | hypothetical protein | - |
| EGH12_RS07540 (EGH12_07540) | - | 1297819..1298199 (-) | 381 | WP_033910829.1 | RusA family crossover junction endodeoxyribonuclease | - |
| EGH12_RS14400 | - | 1298190..1298471 (-) | 282 | WP_003689109.1 | hypothetical protein | - |
| EGH12_RS07545 (EGH12_07545) | - | 1298500..1298649 (-) | 150 | WP_003689110.1 | hypothetical protein | - |
| EGH12_RS07550 (EGH12_07550) | - | 1298826..1299320 (-) | 495 | WP_041421248.1 | DUF3310 domain-containing protein | - |
| EGH12_RS07555 (EGH12_07555) | - | 1299359..1299622 (-) | 264 | WP_154235845.1 | hypothetical protein | - |
| EGH12_RS07560 (EGH12_07560) | - | 1299659..1300903 (-) | 1245 | WP_124935097.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| EGH12_RS07565 (EGH12_07565) | - | 1300900..1301964 (-) | 1065 | WP_050154181.1 | hypothetical protein | - |
| EGH12_RS07570 (EGH12_07570) | - | 1302082..1302309 (-) | 228 | WP_003698261.1 | helix-turn-helix domain-containing protein | - |
| EGH12_RS07580 (EGH12_07580) | - | 1302690..1303406 (+) | 717 | WP_003695999.1 | helix-turn-helix transcriptional regulator | - |
| EGH12_RS07585 (EGH12_07585) | - | 1303566..1304105 (+) | 540 | WP_003695998.1 | type II toxin-antitoxin system antitoxin SocA domain-containing protein | - |
| EGH12_RS07590 (EGH12_07590) | - | 1304106..1304465 (+) | 360 | WP_003691733.1 | hypothetical protein | - |
| EGH12_RS07595 (EGH12_07595) | - | 1304482..1304700 (-) | 219 | WP_003691731.1 | hypothetical protein | - |
| EGH12_RS07600 (EGH12_07600) | - | 1305184..1305384 (+) | 201 | WP_047920246.1 | hypothetical protein | - |
| EGH12_RS07605 (EGH12_07605) | - | 1305417..1305893 (+) | 477 | WP_002255718.1 | hypothetical protein | - |
| EGH12_RS07610 (EGH12_07610) | - | 1305890..1306177 (+) | 288 | WP_041421246.1 | hypothetical protein | - |
| EGH12_RS07615 (EGH12_07615) | - | 1306318..1306650 (+) | 333 | WP_003705604.1 | hypothetical protein | - |
| EGH12_RS07620 (EGH12_07620) | - | 1306803..1307081 (+) | 279 | WP_003691529.1 | hypothetical protein | - |
| EGH12_RS07625 (EGH12_07625) | - | 1307078..1307239 (+) | 162 | WP_003693867.1 | hypothetical protein | - |
| EGH12_RS07630 (EGH12_07630) | - | 1307308..1307994 (+) | 687 | WP_042758540.1 | hypothetical protein | - |
| EGH12_RS07635 (EGH12_07635) | - | 1308134..1308316 (+) | 183 | WP_003691535.1 | hypothetical protein | - |
| EGH12_RS07640 (EGH12_07640) | - | 1308313..1308804 (+) | 492 | WP_047916888.1 | siphovirus Gp157 family protein | - |
| EGH12_RS07645 (EGH12_07645) | - | 1308856..1309071 (+) | 216 | WP_003691538.1 | hypothetical protein | - |
| EGH12_RS14715 | - | 1309182..1309415 (+) | 234 | Protein_1322 | hypothetical protein | - |
| EGH12_RS07655 (EGH12_07655) | - | 1309729..1310412 (+) | 684 | WP_003687929.1 | DUF2786 domain-containing protein | - |
| EGH12_RS07660 (EGH12_07660) | - | 1310607..1310876 (+) | 270 | WP_003687928.1 | hypothetical protein | - |
| EGH12_RS07675 (EGH12_07675) | - | 1311232..1312432 (-) | 1201 | Protein_1325 | integrase arm-type DNA-binding domain-containing protein | - |
| EGH12_RS07690 (EGH12_07690) | yaaA | 1312962..1313741 (-) | 780 | WP_003687925.1 | peroxide stress protein YaaA | - |
| EGH12_RS07695 (EGH12_07695) | dapC | 1313897..1315084 (-) | 1188 | WP_003701073.1 | succinyldiaminopimelate transaminase | - |
| EGH12_RS07700 (EGH12_07700) | dut | 1315156..1315608 (-) | 453 | WP_003701071.1 | dUTP diphosphatase | - |
| EGH12_RS07705 (EGH12_07705) | - | 1315774..1316485 (+) | 712 | Protein_1329 | AzlC family ABC transporter permease | - |
| EGH12_RS07710 (EGH12_07710) | - | 1316482..1316790 (+) | 309 | WP_003706588.1 | AzlD family protein | - |
| EGH12_RS07715 (EGH12_07715) | pilL | 1316860..1317333 (-) | 474 | WP_012503482.1 | PilX family type IV pilin | Machinery gene |
| EGH12_RS07720 (EGH12_07720) | pilK | 1317335..1317943 (-) | 609 | WP_047921847.1 | pilus assembly protein | Machinery gene |
| EGH12_RS07725 (EGH12_07725) | pilJ | 1317922..1318884 (-) | 963 | WP_047921846.1 | PilW family protein | Machinery gene |
| EGH12_RS07730 (EGH12_07730) | pilI | 1318881..1319495 (-) | 615 | WP_012503479.1 | type IV pilus modification protein PilV | Machinery gene |
| EGH12_RS07735 (EGH12_07735) | pilH | 1319527..1320189 (-) | 663 | WP_047916986.1 | Tfp pilus assembly protein FimT/FimU | Machinery gene |
| EGH12_RS07740 (EGH12_07740) | dnaB | 1320446..1321849 (-) | 1404 | WP_012503477.1 | replicative DNA helicase | - |
| EGH12_RS07750 (EGH12_07750) | - | 1322013..1322594 (+) | 582 | WP_003690895.1 | superoxide dismutase | - |
| EGH12_RS07760 (EGH12_07760) | - | 1322826..1323335 (-) | 510 | WP_003687909.1 | isoprenylcysteine carboxyl methyltransferase family protein | - |
| EGH12_RS07765 (EGH12_07765) | - | 1323665..1323997 (-) | 333 | WP_003687908.1 | hypothetical protein | - |
| EGH12_RS07770 (EGH12_07770) | cysT | 1324183..1325012 (+) | 830 | Protein_1340 | sulfate ABC transporter permease subunit CysT | - |
| EGH12_RS07775 (EGH12_07775) | cysW | 1325201..1326022 (+) | 822 | WP_012503473.1 | sulfate ABC transporter permease subunit CysW | - |
| EGH12_RS13835 | - | 1326018..1326125 (+) | 108 | Protein_1342 | IS5/IS1182 family transposase | - |
| EGH12_RS07780 (EGH12_07780) | - | 1326163..1327239 (+) | 1077 | WP_003687905.1 | sulfate/molybdate ABC transporter ATP-binding protein | - |
| EGH12_RS07785 (EGH12_07785) | ilvA | 1327295..1328821 (-) | 1527 | WP_003690890.1 | threonine ammonia-lyase, biosynthetic | - |
| EGH12_RS07790 (EGH12_07790) | - | 1328970..1330139 (+) | 1170 | WP_003690889.1 | D-alanyl-D-alanine carboxypeptidase family protein | - |
Sequence
Protein
Download Length: 220 a.a. Molecular weight: 24557.00 Da Isoelectric Point: 9.6166
>NTDB_id=328147 EGH12_RS07735 WP_047916986.1 1319527..1320189(-) (pilH) [Neisseria gonorrhoeae strain FQ48]
MCTRKQQGFTLTELLIVMAIAAIMATIALPNMSGWIASRRIASHAEQVANLLRFSRGEAVRLNLPVYICPVQVKKDGASN
NRCDFSKKGWGMLAFGDKNDNKAYDGDATDVFLRSVVLNDTDDSRINYTFNHIAFGSSQPKADRVVWTFNQNGTFGYLPD
QNLKNNFKFVYSDGYIQIVLTDARAVSDADKKFRSAVVLINSSGRVEVCRKNDTRAVCKH
MCTRKQQGFTLTELLIVMAIAAIMATIALPNMSGWIASRRIASHAEQVANLLRFSRGEAVRLNLPVYICPVQVKKDGASN
NRCDFSKKGWGMLAFGDKNDNKAYDGDATDVFLRSVVLNDTDDSRINYTFNHIAFGSSQPKADRVVWTFNQNGTFGYLPD
QNLKNNFKFVYSDGYIQIVLTDARAVSDADKKFRSAVVLINSSGRVEVCRKNDTRAVCKH
Nucleotide
Download Length: 663 bp
>NTDB_id=328147 EGH12_RS07735 WP_047916986.1 1319527..1320189(-) (pilH) [Neisseria gonorrhoeae strain FQ48]
ATGTGTACACGAAAACAACAAGGTTTCACGCTAACAGAGCTGCTCATCGTGATGGCCATCGCAGCCATTATGGCGACGAT
AGCCCTCCCCAATATGAGTGGGTGGATTGCATCACGCCGCATTGCCAGTCACGCGGAGCAGGTTGCCAACCTTTTGCGTT
TCTCCAGGGGCGAAGCCGTCCGGCTCAATCTCCCTGTCTATATCTGTCCTGTTCAAGTTAAAAAAGACGGTGCGTCCAAC
AATAGATGTGACTTCAGCAAGAAGGGGTGGGGAATGTTGGCTTTCGGCGACAAAAACGACAATAAGGCATATGACGGCGA
TGCGACGGATGTTTTCCTCCGCAGCGTGGTGTTGAATGATACCGACGACAGCCGGATTAATTACACCTTCAATCATATCG
CTTTCGGTTCGTCTCAGCCGAAAGCCGACCGTGTAGTTTGGACTTTCAACCAAAACGGGACATTCGGCTATTTGCCCGAT
CAGAATCTCAAGAATAATTTCAAATTTGTTTATTCTGACGGTTATATCCAAATCGTGCTGACAGATGCGAGAGCAGTTTC
AGATGCCGATAAGAAATTCCGTTCGGCGGTGGTTTTGATTAACAGCAGCGGCAGGGTCGAAGTTTGTCGTAAAAACGATA
CGCGCGCCGTATGCAAACATTAA
ATGTGTACACGAAAACAACAAGGTTTCACGCTAACAGAGCTGCTCATCGTGATGGCCATCGCAGCCATTATGGCGACGAT
AGCCCTCCCCAATATGAGTGGGTGGATTGCATCACGCCGCATTGCCAGTCACGCGGAGCAGGTTGCCAACCTTTTGCGTT
TCTCCAGGGGCGAAGCCGTCCGGCTCAATCTCCCTGTCTATATCTGTCCTGTTCAAGTTAAAAAAGACGGTGCGTCCAAC
AATAGATGTGACTTCAGCAAGAAGGGGTGGGGAATGTTGGCTTTCGGCGACAAAAACGACAATAAGGCATATGACGGCGA
TGCGACGGATGTTTTCCTCCGCAGCGTGGTGTTGAATGATACCGACGACAGCCGGATTAATTACACCTTCAATCATATCG
CTTTCGGTTCGTCTCAGCCGAAAGCCGACCGTGTAGTTTGGACTTTCAACCAAAACGGGACATTCGGCTATTTGCCCGAT
CAGAATCTCAAGAATAATTTCAAATTTGTTTATTCTGACGGTTATATCCAAATCGTGCTGACAGATGCGAGAGCAGTTTC
AGATGCCGATAAGAAATTCCGTTCGGCGGTGGTTTTGATTAACAGCAGCGGCAGGGTCGAAGTTTGTCGTAAAAACGATA
CGCGCGCCGTATGCAAACATTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pilH | Neisseria gonorrhoeae MS11 |
95.455 |
100 |
0.955 |