Detailed information NTG0032666

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SPN23F_RS02445
• Genome accession: NC_011900
• Coordinates: 464742..465479 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae ATCC 700669
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 459742..470479

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN23F_RS13365 (SPN23F04710)	-	460628..460912 (-)	285	WP_025169639.1	hypothetical protein	-
SPN23F_RS02415 (SPN23F04720)	-	461074..461361 (-)	288	WP_000777753.1	hypothetical protein	-
SPN23F_RS02420 (SPN23F04730)	-	461371..461781 (-)	411	WP_001278301.1	HIT family protein	-
SPN23F_RS02425 (SPN23F04740)	pptA	461849..462580 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
SPN23F_RS02430 (SPN23F04750)	-	462577..463626 (+)	1050	WP_000653774.1	ABC transporter permease	-
SPN23F_RS02435 (SPN23F04760)	-	463794..464123 (-)	330	WP_000132572.1	hypothetical protein	-
SPN23F_RS02440 (SPN23F04770)	-	464399..464737 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
SPN23F_RS02445 (SPN23F04780)	comE/blpR	464742..465479 (+)	738	WP_001219120.1	response regulator transcription factor	Regulator
SPN23F_RS02450 (SPN23F04790)	-	465493..466833 (+)	1341	WP_001017642.1	sensor histidine kinase	-
SPN23F_RS02455 (SPN23F04791)	blpC	466904..467032 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
SPN23F_RS02460 (SPN23F04800)	-	467089..468450 (-)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
SPN23F_RS02465 (SPN23F04810)	comA/nlmT	468461..470137 (-)	1677	WP_196300924.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=32666 SPN23F_RS02445 WP_001219120.1 464742..465479(+) (comE/blpR) [Streptococcus pneumoniae ATCC 700669]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=32666 SPN23F_RS02445 WP_001219120.1 464742..465479(+) (comE/blpR) [Streptococcus pneumoniae ATCC 700669]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363