Detailed information
Bioinformatically predicted
Overview
| Name | comYH | Type | Machinery gene |
| Locus tag | EGX96_RS06095 | Genome accession | NZ_CP033810 |
| Coordinates | 1157480..1158454 (+) | Length | 324 a.a. |
| NCBI ID | WP_001008574.1 | Uniprot ID | A0AAV3JGK6 |
| Organism | Streptococcus sp. FDAARGOS_520 | ||
| Function | dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1159121..1220241 | 1157480..1158454 | flank | 667 |
Gene organization within MGE regions
Location: 1157480..1220241
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EGX96_RS06095 (EGX96_06095) | comYH | 1157480..1158454 (+) | 975 | WP_001008574.1 | class I SAM-dependent methyltransferase | Machinery gene |
| EGX96_RS06100 (EGX96_06100) | - | 1158486..1159679 (+) | 1194 | WP_000047534.1 | acetate kinase | - |
| EGX96_RS06105 (EGX96_06105) | - | 1159831..1160037 (+) | 207 | WP_000798241.1 | helix-turn-helix transcriptional regulator | - |
| EGX96_RS06110 (EGX96_06110) | - | 1160096..1160233 (+) | 138 | WP_001865900.1 | hypothetical protein | - |
| EGX96_RS06115 (EGX96_06115) | - | 1160274..1160729 (+) | 456 | WP_000905673.1 | hypothetical protein | - |
| EGX96_RS06120 (EGX96_06120) | - | 1160798..1161463 (+) | 666 | WP_000008113.1 | CPBP family intramembrane glutamic endopeptidase | - |
| EGX96_RS06125 (EGX96_06125) | proC | 1161484..1162254 (-) | 771 | WP_001865901.1 | pyrroline-5-carboxylate reductase | - |
| EGX96_RS06130 (EGX96_06130) | pepA | 1162324..1163391 (-) | 1068 | WP_001281323.1 | glutamyl aminopeptidase | - |
| EGX96_RS06135 (EGX96_06135) | - | 1163576..1163815 (-) | 240 | WP_000660180.1 | hypothetical protein | - |
| EGX96_RS06140 (EGX96_06140) | - | 1163991..1164260 (+) | 270 | WP_253257585.1 | DUF4651 domain-containing protein | - |
| EGX96_RS06145 (EGX96_06145) | - | 1164257..1164580 (+) | 324 | WP_000602781.1 | thioredoxin family protein | - |
| EGX96_RS06150 (EGX96_06150) | ytpR | 1164613..1165239 (+) | 627 | WP_000578328.1 | YtpR family tRNA-binding protein | - |
| EGX96_RS06155 (EGX96_06155) | - | 1165293..1166009 (-) | 717 | WP_000186185.1 | class I SAM-dependent methyltransferase | - |
| EGX96_RS06160 (EGX96_06160) | ssbA | 1166090..1166485 (+) | 396 | WP_000282447.1 | single-stranded DNA-binding protein | Machinery gene |
| EGX96_RS06165 (EGX96_06165) | - | 1166609..1167253 (+) | 645 | WP_000416612.1 | HAD family phosphatase | - |
| EGX96_RS06170 (EGX96_06170) | - | 1167280..1169025 (+) | 1746 | WP_000930334.1 | LytS/YhcK type 5TM receptor domain-containing protein | - |
| EGX96_RS06175 (EGX96_06175) | - | 1169006..1169746 (+) | 741 | WP_000697630.1 | LytTR family DNA-binding domain-containing protein | - |
| EGX96_RS06180 (EGX96_06180) | - | 1169916..1170371 (+) | 456 | WP_000683316.1 | CidA/LrgA family protein | - |
| EGX96_RS06185 (EGX96_06185) | lrgB | 1170373..1171101 (+) | 729 | WP_000421724.1 | antiholin-like protein LrgB | - |
| EGX96_RS06195 (EGX96_06195) | - | 1171344..1172972 (+) | 1629 | WP_000170504.1 | ABC transporter substrate-binding protein | - |
| EGX96_RS06200 (EGX96_06200) | - | 1173085..1174062 (+) | 978 | WP_000680645.1 | ABC transporter permease | - |
| EGX96_RS06205 (EGX96_06205) | - | 1174059..1174880 (+) | 822 | WP_000603397.1 | ABC transporter permease | - |
| EGX96_RS06210 (EGX96_06210) | - | 1174892..1175695 (+) | 804 | WP_000140984.1 | ABC transporter ATP-binding protein | - |
| EGX96_RS06215 (EGX96_06215) | - | 1175679..1176305 (+) | 627 | WP_000171309.1 | ABC transporter ATP-binding protein | - |
| EGX96_RS06220 (EGX96_06220) | treP | 1176588..1178618 (+) | 2031 | WP_000434616.1 | PTS system trehalose-specific EIIBC component | - |
| EGX96_RS06225 (EGX96_06225) | treC | 1178840..1180465 (+) | 1626 | WP_123957826.1 | alpha,alpha-phosphotrehalase | - |
| EGX96_RS06230 (EGX96_06230) | - | 1180681..1182717 (+) | 2037 | WP_000228183.1 | BglG family transcription antiterminator | - |
| EGX96_RS06235 (EGX96_06235) | - | 1182720..1183004 (+) | 285 | WP_000944235.1 | PTS sugar transporter subunit IIB | - |
| EGX96_RS06240 (EGX96_06240) | - | 1183017..1184372 (+) | 1356 | WP_000677361.1 | PTS ascorbate transporter subunit IIC | - |
| EGX96_RS06245 (EGX96_06245) | - | 1184375..1185232 (+) | 858 | WP_000203489.1 | transketolase | - |
| EGX96_RS06250 (EGX96_06250) | - | 1185229..1186158 (+) | 930 | WP_001203821.1 | transketolase family protein | - |
| EGX96_RS06255 (EGX96_06255) | - | 1186267..1187526 (+) | 1260 | WP_001203068.1 | ferric reductase-like transmembrane domain-containing protein | - |
| EGX96_RS06260 (EGX96_06260) | rpsO | 1187614..1187883 (+) | 270 | WP_001018249.1 | 30S ribosomal protein S15 | - |
| EGX96_RS06265 (EGX96_06265) | pnp | 1188264..1190393 (+) | 2130 | WP_000043850.1 | polyribonucleotide nucleotidyltransferase | - |
| EGX96_RS06270 (EGX96_06270) | - | 1190395..1191147 (+) | 753 | WP_000204782.1 | SseB family protein | - |
| EGX96_RS06275 (EGX96_06275) | cysE | 1191156..1191740 (+) | 585 | WP_000539954.1 | serine O-acetyltransferase | - |
| EGX96_RS06280 (EGX96_06280) | - | 1191750..1191932 (+) | 183 | WP_000656476.1 | lipoprotein | - |
| EGX96_RS06285 (EGX96_06285) | cysS | 1191929..1193272 (+) | 1344 | WP_000591131.1 | cysteine--tRNA ligase | - |
| EGX96_RS06290 (EGX96_06290) | - | 1193265..1193651 (+) | 387 | WP_000568029.1 | Mini-ribonuclease 3 | - |
| EGX96_RS06295 (EGX96_06295) | rlmB | 1193754..1194509 (+) | 756 | WP_000178026.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
| EGX96_RS06300 (EGX96_06300) | - | 1194506..1195024 (+) | 519 | WP_000716636.1 | NYN domain-containing protein | - |
| EGX96_RS06305 (EGX96_06305) | - | 1195117..1195977 (+) | 861 | WP_000143135.1 | DegV family protein | - |
| EGX96_RS11155 (EGX96_06315) | - | 1196514..1196633 (+) | 120 | Protein_1154 | helix-turn-helix transcriptional regulator | - |
| EGX96_RS06320 (EGX96_06320) | rplM | 1196858..1197304 (+) | 447 | WP_001865567.1 | 50S ribosomal protein L13 | - |
| EGX96_RS06325 (EGX96_06325) | rpsI | 1197325..1197717 (+) | 393 | WP_000035940.1 | 30S ribosomal protein S9 | - |
| EGX96_RS06330 (EGX96_06330) | xerC | 1197823..1199046 (-) | 1224 | WP_000156560.1 | tyrosine recombinase XerC | - |
| EGX96_RS06335 (EGX96_06335) | - | 1199101..1199373 (-) | 273 | WP_001196075.1 | helix-turn-helix domain-containing protein | - |
| EGX96_RS06340 (EGX96_06340) | - | 1199484..1199816 (-) | 333 | WP_000371058.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| EGX96_RS06345 (EGX96_06345) | - | 1199803..1200108 (-) | 306 | WP_000162871.1 | hypothetical protein | - |
| EGX96_RS06350 (EGX96_06350) | - | 1200165..1201220 (-) | 1056 | WP_000728345.1 | phage tail tip lysozyme | - |
| EGX96_RS06355 (EGX96_06355) | - | 1201229..1201411 (-) | 183 | WP_001882897.1 | hypothetical protein | - |
| EGX96_RS06360 (EGX96_06360) | - | 1201452..1203383 (-) | 1932 | WP_001154548.1 | hypothetical protein | - |
| EGX96_RS06365 (EGX96_06365) | - | 1203396..1205918 (-) | 2523 | WP_000243267.1 | ATP-binding protein | - |
| EGX96_RS06370 (EGX96_06370) | - | 1205929..1206345 (-) | 417 | WP_000410250.1 | conjugal transfer protein | - |
| EGX96_RS06375 (EGX96_06375) | - | 1206347..1206574 (-) | 228 | WP_000099227.1 | hypothetical protein | - |
| EGX96_RS06380 (EGX96_06380) | - | 1206591..1207583 (-) | 993 | WP_001098866.1 | conjugal transfer protein | - |
| EGX96_RS06385 (EGX96_06385) | - | 1207593..1208147 (-) | 555 | WP_000780011.1 | hypothetical protein | - |
| EGX96_RS06390 (EGX96_06390) | - | 1208144..1208380 (-) | 237 | WP_000456039.1 | hypothetical protein | - |
| EGX96_RS06395 (EGX96_06395) | - | 1208400..1208786 (-) | 387 | WP_000058816.1 | hypothetical protein | - |
| EGX96_RS06400 (EGX96_06400) | - | 1208764..1209996 (-) | 1233 | WP_000625216.1 | replication initiation factor domain-containing protein | - |
| EGX96_RS06405 (EGX96_06405) | - | 1210208..1211866 (-) | 1659 | WP_001882899.1 | FtsK/SpoIIIE domain-containing protein | - |
| EGX96_RS06410 (EGX96_06410) | - | 1211873..1212283 (-) | 411 | WP_000216328.1 | DUF961 family protein | - |
| EGX96_RS06415 (EGX96_06415) | - | 1212306..1212620 (-) | 315 | WP_000406626.1 | hypothetical protein | - |
| EGX96_RS06420 (EGX96_06420) | - | 1212734..1212961 (-) | 228 | WP_001105756.1 | hypothetical protein | - |
| EGX96_RS06425 (EGX96_06425) | - | 1212958..1213194 (-) | 237 | WP_001000876.1 | hypothetical protein | - |
| EGX96_RS06430 (EGX96_06430) | - | 1213323..1213601 (-) | 279 | WP_000285204.1 | type II toxin-antitoxin system YafQ family toxin | - |
| EGX96_RS06435 (EGX96_06435) | - | 1213602..1213874 (-) | 273 | WP_000246822.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| EGX96_RS06440 (EGX96_06440) | - | 1214555..1214917 (+) | 363 | WP_000483806.1 | helix-turn-helix domain-containing protein | - |
| EGX96_RS06445 (EGX96_06445) | - | 1214924..1215775 (+) | 852 | WP_172581992.1 | ImmA/IrrE family metallo-endopeptidase | - |
| EGX96_RS06450 (EGX96_06450) | - | 1215795..1216157 (-) | 363 | WP_000722890.1 | hypothetical protein | - |
| EGX96_RS06455 (EGX96_06455) | - | 1216245..1217795 (-) | 1551 | WP_001145976.1 | DNA cytosine methyltransferase | - |
| EGX96_RS06460 (EGX96_06460) | - | 1217989..1218450 (+) | 462 | WP_000443123.1 | helix-turn-helix transcriptional regulator | - |
| EGX96_RS06465 (EGX96_06465) | - | 1218450..1219670 (+) | 1221 | WP_001159665.1 | MvaI/BcnI family restriction endonuclease | - |
Sequence
Protein
Download Length: 324 a.a. Molecular weight: 37046.02 Da Isoelectric Point: 4.5224
>NTDB_id=325934 EGX96_RS06095 WP_001008574.1 1157480..1158454(+) (comYH) [Streptococcus sp. FDAARGOS_520]
MNFEKIETAYELILENIQTIENQLKTHIYDALIEQNSYYLGSSCDLDMVVVNNQKLRQLDLSQEEWRRTFQFIFIKSAQT
EQLQANHQFTPDSIGFILLFLLEELTSQETVDVLEIGSGTGNLAQTLLNNSSKELNYMGIEVDDLLIDLSASIAEIIGSS
AQFIQEDAVRPQILKESDVIISDLPVGYYPNDGIAKRYAVSSSKEHTYAHHLLMEQSLKYLKKDGIAIFLAPENLLTSPQ
SDLLKEWLKGYADVIAVLTLPETIFGSRQNAKSIFVLKKQAEQKPETFVYPLTDLQNRENMANFIENFQKWSRENSHYSK
NMIK
MNFEKIETAYELILENIQTIENQLKTHIYDALIEQNSYYLGSSCDLDMVVVNNQKLRQLDLSQEEWRRTFQFIFIKSAQT
EQLQANHQFTPDSIGFILLFLLEELTSQETVDVLEIGSGTGNLAQTLLNNSSKELNYMGIEVDDLLIDLSASIAEIIGSS
AQFIQEDAVRPQILKESDVIISDLPVGYYPNDGIAKRYAVSSSKEHTYAHHLLMEQSLKYLKKDGIAIFLAPENLLTSPQ
SDLLKEWLKGYADVIAVLTLPETIFGSRQNAKSIFVLKKQAEQKPETFVYPLTDLQNRENMANFIENFQKWSRENSHYSK
NMIK
Nucleotide
Download Length: 975 bp
>NTDB_id=325934 EGX96_RS06095 WP_001008574.1 1157480..1158454(+) (comYH) [Streptococcus sp. FDAARGOS_520]
ATGAATTTTGAAAAAATTGAGACAGCCTATGAGCTGATTTTAGAAAATATCCAAACGATTGAGAACCAATTAAAAACTCA
TATTTATGATGCCTTAATTGAACAGAACTCTTATTACCTTGGTTCAAGTTGTGATTTAGATATGGTTGTGGTGAATAACC
AAAAATTACGTCAACTTGACTTAAGTCAAGAAGAATGGCGTCGCACTTTCCAGTTCATTTTTATCAAATCTGCGCAAACA
GAGCAATTACAAGCTAATCATCAGTTTACGCCAGATAGTATTGGTTTTATCTTGTTATTTCTTTTGGAAGAATTAACGAG
TCAAGAGACAGTGGATGTCTTGGAAATTGGAAGTGGAACTGGGAATTTAGCTCAGACTCTCCTCAATAACAGCTCGAAAG
AGTTAAATTATATGGGCATTGAAGTTGATGATCTTTTGATTGATCTATCAGCAAGCATTGCTGAAATTATAGGTTCTAGT
GCCCAATTTATCCAAGAGGATGCTGTTAGACCACAAATTTTGAAAGAAAGCGATGTAATCATTAGTGATTTACCAGTTGG
CTATTATCCTAATGATGGTATTGCTAAACGATATGCTGTATCAAGTTCTAAAGAGCACACCTATGCTCACCATCTATTGA
TGGAGCAATCTCTTAAATATTTGAAAAAAGATGGAATCGCTATATTTTTAGCACCCGAAAACCTTTTAACAAGTCCACAA
AGTGATTTGCTGAAGGAGTGGTTAAAAGGATATGCAGATGTCATTGCCGTTTTAACTCTACCAGAAACTATTTTTGGAAG
TCGTCAAAATGCGAAATCTATATTTGTTCTCAAGAAGCAAGCAGAACAAAAACCAGAAACCTTTGTATATCCGCTGACAG
ATTTGCAAAATCGTGAGAATATGGCAAACTTCATTGAAAATTTTCAAAAATGGAGCAGAGAAAATAGTCATTACTCAAAA
AATATGATAAAATAG
ATGAATTTTGAAAAAATTGAGACAGCCTATGAGCTGATTTTAGAAAATATCCAAACGATTGAGAACCAATTAAAAACTCA
TATTTATGATGCCTTAATTGAACAGAACTCTTATTACCTTGGTTCAAGTTGTGATTTAGATATGGTTGTGGTGAATAACC
AAAAATTACGTCAACTTGACTTAAGTCAAGAAGAATGGCGTCGCACTTTCCAGTTCATTTTTATCAAATCTGCGCAAACA
GAGCAATTACAAGCTAATCATCAGTTTACGCCAGATAGTATTGGTTTTATCTTGTTATTTCTTTTGGAAGAATTAACGAG
TCAAGAGACAGTGGATGTCTTGGAAATTGGAAGTGGAACTGGGAATTTAGCTCAGACTCTCCTCAATAACAGCTCGAAAG
AGTTAAATTATATGGGCATTGAAGTTGATGATCTTTTGATTGATCTATCAGCAAGCATTGCTGAAATTATAGGTTCTAGT
GCCCAATTTATCCAAGAGGATGCTGTTAGACCACAAATTTTGAAAGAAAGCGATGTAATCATTAGTGATTTACCAGTTGG
CTATTATCCTAATGATGGTATTGCTAAACGATATGCTGTATCAAGTTCTAAAGAGCACACCTATGCTCACCATCTATTGA
TGGAGCAATCTCTTAAATATTTGAAAAAAGATGGAATCGCTATATTTTTAGCACCCGAAAACCTTTTAACAAGTCCACAA
AGTGATTTGCTGAAGGAGTGGTTAAAAGGATATGCAGATGTCATTGCCGTTTTAACTCTACCAGAAACTATTTTTGGAAG
TCGTCAAAATGCGAAATCTATATTTGTTCTCAAGAAGCAAGCAGAACAAAAACCAGAAACCTTTGTATATCCGCTGACAG
ATTTGCAAAATCGTGAGAATATGGCAAACTTCATTGAAAATTTTCAAAAATGGAGCAGAGAAAATAGTCATTACTCAAAA
AATATGATAAAATAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comYH | Streptococcus mutans UA159 |
67.302 |
97.222 |
0.654 |
| comYH | Streptococcus mutans UA140 |
67.302 |
97.222 |
0.654 |