Detailed information NTG0306648

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: DXX91_RS00580
• Genome accession: NZ_CP031424
• Coordinates: 104213..106648 (+)
• Length: 811 a.a.
• NCBI ID: WP_017419467.1
• Uniprot ID: A0A411A1F9
• Organism: Bacillus velezensis strain B-4
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 99213..111648

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXX91_RS00565	ctsR	102090..102554 (+)	465	WP_003156396.1	transcriptional regulator CtsR	-
DXX91_RS00570	-	102568..103125 (+)	558	WP_003156397.1	UvrB/UvrC motif-containing protein	-
DXX91_RS00575	-	103125..104216 (+)	1092	WP_003156398.1	protein arginine kinase	-
DXX91_RS00580	clpC	104213..106648 (+)	2436	WP_017419467.1	ATP-dependent protease ATP-binding subunit ClpC	Regulator
DXX91_RS00585	radA	106742..108121 (+)	1380	WP_014304212.1	DNA repair protein RadA	Machinery gene
DXX91_RS00590	disA	108125..109207 (+)	1083	WP_003156401.1	DNA integrity scanning diadenylate cyclase DisA	-
DXX91_RS00595	-	109321..110421 (+)	1101	WP_003156403.1	PIN/TRAM domain-containing protein	-
DXX91_RS00600	ispD	110434..111132 (+)	699	WP_003156405.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
DXX91_RS00605	ispF	111125..111601 (+)	477	WP_003156407.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-

Sequence

Protein

• Length: 811 a.a.
• Molecular weight: 90134.55 Da
• Isoelectric Point: 5.8528

>NTDB_id=306648 DXX91_RS00580 WP_017419467.1 104213..106648(+) (clpC) [Bacillus velezensis strain B-4]
MMFGRFTERAQKVLALAQEEALRLGHTNIGTEHILLGLVREGEGIAFKALEALGLNSDKMQKEVESLIGRGQESATSVPH
YTPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSASGTNSNAN
TPTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIINNEVPEILRDKRV
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDE
YRKYIEKDAALERRFQPIQVDQPSADESIQILKGLRDRYEAHHRVSITDEAIEAAVKLSDRYISDRFLPDKAIDLIDEAG
SKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKTWKEKQGQENSEVSVEDIAMV
VSSWTGVPVSKIAQTETDKLLNMESILHSRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALA
ESIFGDEEAMIRVDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLEDGRL
TDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDESQNHKDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHL
TDIVSLMSDQLTKRLKEQDLSIELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIDKGQHIVLDVEDG
EFVVKTTAKTN

Nucleotide

• Length: 2436 bp

>NTDB_id=306648 DXX91_RS00580 WP_017419467.1 104213..106648(+) (clpC) [Bacillus velezensis strain B-4]
ATGATGTTTGGAAGGTTTACAGAGCGAGCTCAAAAGGTATTGGCACTGGCACAGGAGGAAGCACTGCGCTTAGGCCATAC
AAATATCGGAACTGAACATATACTATTAGGGTTAGTCCGTGAAGGTGAAGGGATCGCATTTAAAGCTTTAGAAGCTCTTG
GCCTTAATTCAGATAAAATGCAGAAAGAAGTGGAAAGTTTGATCGGTCGAGGGCAGGAAAGTGCCACCTCTGTTCCTCAT
TACACACCTCGAGCCAAAAAGGTAATAGAGCTATCAATGGATGAAGCCAGAAAGCTAGGACATTCTTATGTGGGAACAGA
ACACATACTTCTCGGATTGATCCGTGAAGGAGAAGGCGTGGCGGCGAGAGTTCTGAATAATCTCGGTGTCAGCTTGAATA
AAGCGAGACAGCAAGTGCTGCAGCTTCTGGGAAGCAATGAGACGGGGTCTTCTGCATCCGGTACCAACAGCAATGCAAAC
ACGCCGACGCTTGACAGTTTGGCGCGTGATTTAACTGCGATTGCGAAGGAAGACAGTCTTGATCCGGTTATCGGGCGAAG
CAAAGAAATTCAGCGTGTTATTGAGGTATTAAGCCGCAGAACGAAAAATAATCCCGTTCTTATCGGAGAACCGGGTGTAG
GTAAAACTGCGATTGCTGAAGGCCTTGCACAGCAGATCATCAATAATGAAGTGCCGGAAATTTTACGTGATAAACGCGTA
ATGACGTTAGACATGGGTACGGTTGTAGCCGGTACGAAATACCGCGGAGAATTTGAAGACCGCTTGAAAAAAGTAATGGA
TGAAATACGTCAGGCCGGCAATATTATTTTATTCATTGACGAACTGCATACACTGATCGGAGCAGGGGGAGCAGAAGGTG
CGATTGACGCATCGAATATTTTAAAACCTTCACTGGCCCGCGGAGAGCTTCAATGCATCGGTGCCACAACGCTTGATGAA
TACCGTAAATATATCGAAAAAGACGCGGCTCTCGAGCGCCGTTTCCAGCCGATTCAGGTGGATCAGCCGTCAGCCGATGA
AAGCATTCAAATTTTAAAAGGGCTCCGTGACCGCTATGAAGCGCATCACCGCGTATCCATTACCGATGAAGCGATCGAAG
CCGCGGTTAAATTGTCCGACCGTTATATTTCTGACCGCTTCCTTCCGGATAAAGCGATCGATTTAATTGATGAAGCCGGT
TCAAAAGTGCGTCTCCGTTCTTTCACAACGCCTCCGAACTTAAAAGAGCTTGAGCAGAAACTCGATGAAGTTCGCAAGGA
AAAAGACGCTGCCGTTCAGAGCCAGGAGTTTGAAAAAGCGGCTTCCCTTCGTGATACGGAGCAGCGCCTGAGAGAACAGG
TGGAAGACACGAAAAAAACCTGGAAAGAAAAACAAGGCCAGGAGAACTCCGAAGTTTCTGTAGAGGATATCGCGATGGTT
GTATCCAGCTGGACCGGGGTGCCCGTATCTAAAATTGCCCAAACGGAAACAGATAAGCTTCTCAATATGGAAAGCATTCT
GCATTCCCGCGTCATCGGCCAGGATGAAGCCGTTGTAGCCGTGGCAAAGGCTGTCAGACGTGCAAGAGCCGGACTGAAGG
ACCCGAAACGTCCGATTGGTTCATTCATCTTCTTAGGCCCTACAGGCGTTGGGAAGACAGAGCTGGCAAGAGCGCTGGCG
GAATCCATTTTCGGTGATGAGGAAGCGATGATCAGAGTGGATATGTCCGAATACATGGAGAAACACTCGACTTCACGTCT
TGTCGGTTCTCCTCCGGGATATGTCGGCTATGATGAAGGCGGCCAGCTGACAGAAAAAGTGAGAAGAAAACCTTACTCTG
TCGTATTGCTTGATGAAATTGAAAAAGCGCACCCTGATGTGTTTAACATTCTCCTGCAAGTGCTTGAAGACGGACGCTTG
ACTGATTCAAAAGGACGCACTGTGGATTTCCGCAACACGATCCTGATTATGACGTCAAACGTCGGGGCGAGCGAGCTGAA
GCGCAACAAATATGTAGGCTTCAATGTCCAGGATGAATCACAAAACCATAAAGACATGAAAGACAAAGTCATGGGAGAGC
TGAAGCGTGCCTTCAGACCTGAGTTTATCAACCGGATTGACGAAATTATCGTCTTCCACTCCCTTGAGAAAAAACATCTT
ACAGACATCGTGTCGCTTATGTCTGATCAGTTAACAAAACGTCTGAAAGAACAAGATCTCTCTATCGAGCTGACGGATGC
TGCCAAAGCAAAAGTAGCAGAAGAGGGCGTCGATTTGGAATACGGCGCACGTCCGTTAAGAAGAGCGATTCAAAAGCATG
TGGAGGACCGGTTATCAGAAGAACTCCTCAGAGGCAATATTGATAAAGGCCAGCACATTGTTCTTGATGTTGAGGACGGC
GAATTTGTCGTAAAAACAACTGCTAAAACGAACTAA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (206-318)

• AAA lid domain (AAA_lid_9) (344-445)

• AAA domain (Cdc48 subfamily) (AAA_2) (537-709)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (715-794)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (94-144)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-69)

3D structure

• AlphaFold DB: A0A411A1F9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	96.917	100	0.969
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	49.688	98.767	0.491
clpC	Streptococcus thermophilus LMD-9	46.359	100	0.471
clpC	Streptococcus thermophilus LMG 18311	46.117	100	0.469
clpC	Streptococcus pneumoniae Rx1	45.141	100	0.453
clpC	Streptococcus pneumoniae D39	45.141	100	0.453
clpC	Streptococcus mutans UA159	44.203	100	0.451
clpC	Streptococcus pneumoniae TIGR4	44.772	100	0.449
clpE	Streptococcus mutans UA159	53.313	80.025	0.427
clpC	Lactococcus lactis subsp. cremoris KW2	49.709	84.834	0.422
clpE	Streptococcus pneumoniae TIGR4	52.388	80.025	0.419
clpE	Streptococcus pneumoniae Rx1	52.388	80.025	0.419
clpE	Streptococcus pneumoniae D39	52.388	80.025	0.419
clpE	Streptococcus pneumoniae R6	52.388	80.025	0.419