Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   SPCG_RS10035 Genome accession   NC_010582
Coordinates   1895761..1897017 (-) Length   418 a.a.
NCBI ID   WP_000642711.1    Uniprot ID   B2IM29
Organism   Streptococcus pneumoniae CGSP14     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1890761..1902017
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPCG_RS10010 - 1890831..1891037 (-) 207 WP_000366093.1 hypothetical protein -
  SPCG_RS10015 (SPCG_1965) - 1891024..1891185 (-) 162 WP_001055999.1 helix-turn-helix domain-containing protein -
  SPCG_RS10020 (SPCG_1911) lytA 1891531..1892487 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  SPCG_RS10025 (SPCG_1912) - 1892863..1894233 (-) 1371 WP_001036280.1 MATE family efflux transporter -
  SPCG_RS10030 (SPCG_1913) recA 1894540..1895706 (-) 1167 WP_001085463.1 recombinase RecA Machinery gene
  SPCG_RS10035 (SPCG_1914) cinA 1895761..1897017 (-) 1257 WP_000642711.1 competence/damage-inducible protein A Machinery gene
  SPCG_RS10040 (SPCG_1915) brpA 1897102..1898118 (-) 1017 WP_000239278.1 biofilm formation/cell division transcriptional regulator BrpA -
  SPCG_RS10045 (SPCG_1916) - 1898126..1898644 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  SPCG_RS10050 (SPCG_1917) tsaE 1898634..1899077 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  SPCG_RS10055 (SPCG_1918) - 1899163..1899782 (-) 620 Protein_1887 hypothetical protein -
  SPCG_RS10060 (SPCG_1919) - 1900165..1901028 (-) 864 WP_001093619.1 helix-turn-helix domain-containing protein -
  SPCG_RS10065 (SPCG_1920) - 1901217..1901387 (+) 171 WP_000742180.1 PhrA family quorum-sensing system peptide -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45207.60 Da        Isoelectric Point: 4.5700

>NTDB_id=30637 SPCG_RS10035 WP_000642711.1 1895761..1897017(-) (cinA) [Streptococcus pneumoniae CGSP14]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVTNFSEVSSIFKSGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=30637 SPCG_RS10035 WP_000642711.1 1895761..1897017(-) (cinA) [Streptococcus pneumoniae CGSP14]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGAAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGCTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGACGAATTTTTCTGAAGTTTCAAGTATATTTAAGAGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGAGCAGGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B2IM29

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

98.804

100

0.988
  cinA Streptococcus pneumoniae Rx1

98.565

100

0.986
  cinA Streptococcus pneumoniae R6

98.565

100

0.986
  cinA Streptococcus pneumoniae D39

98.325

100

0.983
  cinA Streptococcus mitis SK321

93.301

100

0.933
  cinA Streptococcus mitis NCTC 12261

93.062

100

0.931
  cinA Streptococcus mutans UA159

70.335

100

0.703
  cinA Streptococcus suis isolate S10

54.808

99.522

0.545
  cinA Bacillus subtilis subsp. subtilis str. 168

45.215

100

0.452

Multiple sequence alignment