Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   DV369_RS00125 Genome accession   NZ_CP031239
Coordinates   25068..26411 (+) Length   447 a.a.
NCBI ID   WP_114893696.1    Uniprot ID   -
Organism   Haemophilus influenzae strain M13034     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 20068..31411
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV369_RS00100 - 20124..22724 (-) 2601 WP_050948872.1 penicillin-binding protein 1A -
  DV369_RS00105 comA 22823..23620 (+) 798 WP_050948871.1 pilus assembly protein PilM Machinery gene
  DV369_RS00110 comB 23621..24130 (+) 510 WP_050948870.1 hypothetical protein Machinery gene
  DV369_RS00115 comC 24127..24648 (+) 522 WP_114893694.1 competence protein ComC Machinery gene
  DV369_RS00120 comD 24645..25058 (+) 414 WP_114893695.1 pilus assembly protein PilP Machinery gene
  DV369_RS00125 comE 25068..26411 (+) 1344 WP_114893696.1 type IV pilus secretin PilQ family protein Machinery gene
  DV369_RS00130 tnpA 26408..26863 (+) 456 WP_105888566.1 IS200/IS605 family transposase -
  DV369_RS00135 - 27177..27863 (+) 687 WP_114893697.1 ComF family protein -
  DV369_RS00140 nfuA 27939..28535 (+) 597 WP_021034385.1 Fe-S biogenesis protein NfuA -
  DV369_RS00145 nudC 28603..29397 (+) 795 WP_021034386.1 NAD(+) diphosphatase -
  DV369_RS00150 - 29433..30023 (+) 591 WP_021034387.1 YjaG family protein -
  DV369_RS00155 - 30162..30434 (+) 273 WP_005630954.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 447 a.a.        Molecular weight: 49383.62 Da        Isoelectric Point: 7.4756

>NTDB_id=304420 DV369_RS00125 WP_114893696.1 25068..26411(+) (comE) [Haemophilus influenzae strain M13034]
MKKYLLKRGYFLVCFCLPLIVFANPKTDNERFFIRLSQAPLAQTLEQLAFQQDVNLVMDEALESNISLRLDNIDMPRLLQ
IIAKSKKLTLNKDEGIYYLNGGQSGKGQVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTAGSGSLLSPAGSITFDDRSN
LLVIQDEPRSVQNIKKLIAEMDKSIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLAGNSFENIADNLNVN
FATTTTPAGSIALQVAKINSRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYVVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVSYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKKLQ

Nucleotide


Download         Length: 1344 bp        

>NTDB_id=304420 DV369_RS00125 WP_114893696.1 25068..26411(+) (comE) [Haemophilus influenzae strain M13034]
ATGAAGAAATATCTTTTAAAGCGCGGTTATTTTTTAGTGTGTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCTAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCCCAAACATTGGAACAATTGGCTTTTCAACAAGATG
TGAATTTAGTGATGGATGAAGCATTAGAAAGTAATATTTCATTGAGATTAGATAATATTGATATGCCACGTTTACTACAA
ATAATCGCTAAAAGTAAGAAGCTTACTTTGAATAAAGATGAGGGCATTTACTATCTGAATGGAGGGCAATCTGGCAAAGG
TCAAGTTGCAGGAAATCTTACTACAAATGAACCGCACTTAGTGAGTCACACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAGTCCTTAACGGCAGGAAGTGGTTCTTTGCTTTCGCCTGCAGGGAGCATTACCTTTGATGATCGTAGTAAT
TTGCTCGTGATTCAAGATGAACCTCGTTCTGTGCAAAATATTAAAAAACTAATTGCTGAAATGGATAAATCTATTGAGCA
GATTGCTATTGAAGCACGTATTGTGACAATTACGGATGAGAGTTTGAAAGAACTTGGTGTTCGTTGGGGGATTTTTAATC
CAACTGAAAATGCAAGACGAGTAGCGGGCAGTCTTGCAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCGATAGCATTACAAGTCGCGAAAATTAATAGTCGATTGCTTGATTTAGAATT
GAGTGCTTTGGAGCGTGAAAATAATGTAGAAATTATCGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGTACAGAAATTCCTTATGTTGTGAGCAATACTCGTAATGATACACAATCTGTGGAATTTCGCGAGGCAGTG
CTTGGTTTGGAAGTGACGCCACATATTTCTAAAGATAACAATATTTTGCTTGATTTATTAGTGAGCCAAAATTCCCCCGG
TTCTCGAGTTTCTTATGGACAAAACGAGGTGGTTTCTATTGATAAGCAAGAGATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTGTTCCACGATACGATCACGAAAAGCGAAGATAAAGTGCCATTACTTGGCGATATA
CCCGTCATTAAACGATTATTCAGCAAAGAAAGCGAACGACATCAAAAACGTGAGTTAGTGATTTTTGTCACGCCGCATAT
TTTAAAAGCTGGGGAAACGTTAGAGGCGTTGAAGCAAAAAAGTGCGGGGAAAAAGTTACAATGA

Domains

Predicted by InterproScan.

Bacterial type II and III secretion system protein (Secretin)

(269-429)

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae Rd KW20

95.506

99.553

0.951
  comE Haemophilus influenzae 86-028NP

95.281

99.553

0.949
  comE Glaesserella parasuis strain SC1401

52.706

95.078

0.501
  pilQ Vibrio campbellii strain DS40M4

42.959

93.736

0.403
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

41.99

92.17

0.387
  pilQ Vibrio cholerae strain A1552

41.99

92.17

0.387

Multiple sequence alignment