Detailed information NTG0294520

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CSC57_RS13570
• Genome accession: NZ_CP029649
• Coordinates: 2638198..2639241 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AR_0472
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2633198..2644241

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSC57_RS13525	-	2633627..2633737 (+)	111	WP_001790257.1	hypothetical protein	-
CSC57_RS13530 (CSC57_2496)	-	2633766..2634179 (+)	414	WP_025173836.1	hypothetical protein	-
CSC57_RS13540 (CSC57_2497)	-	2634610..2635596 (-)	987	WP_000999714.1	aromatic acid exporter family protein	-
CSC57_RS13555 (CSC57_2498)	map	2636124..2636882 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CSC57_RS13560 (CSC57_2499)	-	2637099..2637485 (+)	387	WP_001110179.1	hypothetical protein	-
CSC57_RS13565 (CSC57_2500)	liaF	2637500..2638201 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CSC57_RS13570 (CSC57_2501)	vraS	2638198..2639241 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CSC57_RS13575 (CSC57_2502)	vraR	2639231..2639860 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
CSC57_RS13580 (CSC57_2503)	-	2639972..2641189 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
CSC57_RS13585 (CSC57_2504)	-	2641467..2641742 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
CSC57_RS13590 (CSC57_2505)	-	2641749..2642213 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CSC57_RS13595 (CSC57_2506)	-	2642360..2642560 (+)	201	WP_000180460.1	DUF1128 family protein	-
CSC57_RS13600 (CSC57_2507)	-	2642563..2643819 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=294520 CSC57_RS13570 WP_001017131.1 2638198..2639241(+) (vraS) [Staphylococcus aureus strain AR_0472]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=294520 CSC57_RS13570 WP_001017131.1 2638198..2639241(+) (vraS) [Staphylococcus aureus strain AR_0472]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1