Detailed information NTG0281671

Bioinformatically predicted

Overview

• Name: comYH
• Type: Machinery gene
• Locus tag: C9I27_RS00695
• Genome accession: NZ_CP028148
• Coordinates: 105328..106281 (+)
• Length: 317 a.a.
• NCBI ID: WP_002987790.1
• Uniprot ID: A0A5S4TCX5
• Organism: Streptococcus pyogenes strain TJ11-001
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 100328..111281

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C9I27_RS00655	-	101155..101520 (+)	366	WP_002986560.1	DUF1033 family protein	-
C9I27_RS00660	comYA	101613..102551 (+)	939	WP_002987773.1	competence type IV pilus ATPase ComGA	Machinery gene
C9I27_RS00665	comYB	102487..103521 (+)	1035	WP_223845212.1	competence type IV pilus assembly protein ComGB	Machinery gene
C9I27_RS00670	comYC	103523..103849 (+)	327	WP_002986552.1	competence type IV pilus major pilin ComGC	Machinery gene
C9I27_RS00675	comGD	103824..104252 (+)	429	WP_002986548.1	competence type IV pilus minor pilin ComGD	-
C9I27_RS00680	comGE	104209..104493 (+)	285	WP_002987779.1	competence type IV pilus minor pilin ComGE	-
C9I27_RS00685	comYF	104486..104920 (+)	435	WP_002987783.1	competence type IV pilus minor pilin ComGF	Machinery gene
C9I27_RS00690	comGG	104904..105230 (+)	327	WP_002987787.1	competence type IV pilus minor pilin ComGG	-
C9I27_RS00695	comYH	105328..106281 (+)	954	WP_002987790.1	class I SAM-dependent methyltransferase	Machinery gene
C9I27_RS00700	-	106340..107536 (+)	1197	WP_002987791.1	acetate kinase	-
C9I27_RS00705	-	107723..108031 (+)	309	WP_002987795.1	hypothetical protein	-
C9I27_RS00710	proC	108114..108884 (-)	771	WP_002986527.1	pyrroline-5-carboxylate reductase	-
C9I27_RS00715	pepA	108932..109999 (-)	1068	WP_002987798.1	glutamyl aminopeptidase	-
C9I27_RS00725	-	110464..110745 (+)	282	WP_024623420.1	DUF4651 domain-containing protein	-
C9I27_RS00730	-	110745..111062 (+)	318	WP_002987805.1	thioredoxin family protein	-

Sequence

Protein

• Length: 317 a.a.
• Molecular weight: 35985.08 Da
• Isoelectric Point: 4.7205

>NTDB_id=281671 C9I27_RS00695 WP_002987790.1 105328..106281(+) (comYH) [Streptococcus pyogenes strain TJ11-001]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLAPVNLLTSPQ
SQLLKQWLKDYAQVVALITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide

• Length: 954 bp

>NTDB_id=281671 C9I27_RS00695 WP_002987790.1 105328..106281(+) (comYH) [Streptococcus pyogenes strain TJ11-001]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACT
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAGATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCCAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACTTGAAAAAAGACGGTTTTGCGATTTTTCTGGCACCAGTCAATTTATTGACGAGCCCTCAG
AGTCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGGCCTTGATTACGCTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

• N-6 DNA Methylase (N6_Mtase) (68-288)

3D structure

• AlphaFold DB: A0A5S4TCX5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYH	Streptococcus mutans UA159	66.139	99.685	0.659
comYH	Streptococcus mutans UA140	65.823	99.685	0.656