Detailed information NTG0266409

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RK79_RS12845
• Genome accession: NZ_CP026067
• Coordinates: 2512299..2513342 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FDAARGOS_21
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2507299..2518342

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RK79_RS12815 (RK79_012820)	-	2507720..2508976 (-)	1257	WP_078103411.1	aminopeptidase	-
RK79_RS12820 (RK79_012825)	-	2508979..2509179 (-)	201	WP_000180462.1	DUF1128 family protein	-
RK79_RS12825 (RK79_012830)	-	2509326..2509790 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RK79_RS12830 (RK79_012835)	-	2509797..2510072 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
RK79_RS12835 (RK79_012840)	-	2510350..2511567 (+)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
RK79_RS12840 (RK79_012845)	vraR	2511680..2512309 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
RK79_RS12845 (RK79_012850)	vraS	2512299..2513342 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RK79_RS12850 (RK79_012855)	liaF	2513339..2514040 (-)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
RK79_RS12855 (RK79_012860)	-	2514055..2514441 (-)	387	WP_001110179.1	hypothetical protein	-
RK79_RS12860 (RK79_012865)	map	2514658..2515416 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RK79_RS12880 (RK79_012885)	-	2516113..2517099 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
RK79_RS12885 (RK79_012890)	-	2517288..2517701 (-)	414	WP_025174475.1	hypothetical protein	-
RK79_RS12890 (RK79_012895)	-	2517730..2517840 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=266409 RK79_RS12845 WP_001017131.1 2512299..2513342(-) (vraS) [Staphylococcus aureus strain FDAARGOS_21]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=266409 RK79_RS12845 WP_001017131.1 2512299..2513342(-) (vraS) [Staphylococcus aureus strain FDAARGOS_21]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1