Detailed information NTG0024386

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STR_RS07685
• Genome accession: NC_006449
• Coordinates: 1455246..1456031 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus CNRZ1066
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1450246..1461031

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STR_RS07655 (str1627)	gatC	1450312..1450614 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STR_RS07660 (str1628)	-	1450754..1451008 (-)	255	WP_011226449.1	glycosyl transferase	-
STR_RS10235 (str1629)	-	1451021..1451218 (-)	198	WP_231108739.1	glycosyltransferase	-
STR_RS07665	-	1451546..1452987 (-)	1442	Protein_1449	6-phospho-beta-glucosidase	-
STR_RS07670 (str1632)	msrA	1453140..1453649 (-)	510	WP_041827089.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STR_RS07675 (str1633)	-	1453661..1454509 (-)	849	WP_041827090.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STR_RS07680 (str1634)	-	1454632..1455183 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
STR_RS07685 (str1635)	codY	1455246..1456031 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STR_RS07690 (str1636)	-	1456291..1457505 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
STR_RS07695 (str1637)	-	1457860..1458312 (+)	453	WP_002946987.1	universal stress protein	-
STR_RS10240	-	1458492..1459063 (+)	572	Protein_1456	IS30 family transposase	-
STR_RS07705 (str1639)	-	1459279..1459749 (-)	471	WP_011227497.1	membrane protein	-
STR_RS07710 (str1640)	pflA	1459955..1460755 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=24386 STR_RS07685 WP_002951720.1 1455246..1456031(-) (codY) [Streptococcus thermophilus CNRZ1066]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=24386 STR_RS07685 WP_002951720.1 1455246..1456031(-) (codY) [Streptococcus thermophilus CNRZ1066]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502