Detailed information NTG0024296

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STU_RS17035
• Genome accession: NC_006448
• Coordinates: 1447606..1448391 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus LMG 18311
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1442606..1453391

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STU_RS17005 (stu1627)	gatC	1442667..1442969 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STU_RS17010 (stu1628)	-	1443109..1443363 (-)	255	WP_011226449.1	glycosyl transferase	-
STU_RS19680 (stu1629)	-	1443376..1443585 (-)	210	WP_011226450.1	glycosyltransferase	-
STU_RS17015 (stu1631)	-	1443901..1445347 (-)	1447	Protein_1418	6-phospho-beta-glucosidase	-
STU_RS17020 (stu1632)	msrA	1445500..1446009 (-)	510	WP_002951714.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STU_RS17025 (stu1633)	-	1446021..1446869 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STU_RS17030 (stu1634)	-	1446992..1447543 (-)	552	WP_011226455.1	cysteine hydrolase family protein	-
STU_RS17035 (stu1635)	codY	1447606..1448391 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STU_RS17040 (stu1636)	-	1448651..1449865 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
STU_RS17045 (stu1637)	-	1450220..1450672 (+)	453	WP_002946987.1	universal stress protein	-
STU_RS20735	-	1450852..1451423 (+)	572	Protein_1425	IS30 family transposase	-
STU_RS20260	-	1451495..1451668 (-)	174	WP_011681546.1	hypothetical protein	-
STU_RS17055 (stu1639)	-	1451729..1452103 (-)	375	WP_041828320.1	membrane protein	-
STU_RS17060 (stu1640)	pflA	1452315..1453115 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=24296 STU_RS17035 WP_002951720.1 1447606..1448391(-) (codY) [Streptococcus thermophilus LMG 18311]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=24296 STU_RS17035 WP_002951720.1 1447606..1448391(-) (codY) [Streptococcus thermophilus LMG 18311]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502