Detailed information NTG0023970

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: STR_RS05490
• Genome accession: NC_006449
• Coordinates: 1020596..1021477 (-)
• Length: 293 a.a.
• NCBI ID: WP_011226089.1
• Uniprot ID: Q5M441
• Organism: Streptococcus thermophilus CNRZ1066
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1015596..1026477

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STR_RS05465 (str1160)	vicR	1016296..1017003 (-)	708	WP_011227274.1	response regulator YycF	Regulator
STR_RS05470 (str1161)	-	1017535..1018302 (+)	768	WP_011227275.1	amino acid ABC transporter ATP-binding protein	-
STR_RS05475 (str1162)	-	1018314..1019147 (+)	834	WP_011227276.1	transporter substrate-binding domain-containing protein	-
STR_RS05480 (str1163)	-	1019165..1019863 (+)	699	WP_011226087.1	amino acid ABC transporter permease	-
STR_RS05485 (str1164)	-	1019875..1020525 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
STR_RS05490 (str1165)	endA	1020596..1021477 (-)	882	WP_011226089.1	DNA/RNA non-specific endonuclease	Machinery gene
STR_RS05495 (str1166)	-	1021539..1021727 (-)	189	WP_011227277.1	DNA-directed RNA polymerase subunit beta	-
STR_RS05500 (str1167)	murA	1021729..1023000 (-)	1272	WP_041827046.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
STR_RS05505 (str1168)	-	1023070..1023306 (-)	237	WP_002946959.1	DUF1146 family protein	-
STR_RS05510 (str1169)	galE	1023494..1024507 (-)	1014	WP_011227279.1	UDP-glucose 4-epimerase GalE	-
STR_RS05515 (str1170)	-	1024522..1024977 (-)	456	WP_041827047.1	DUF4832 domain-containing protein	-

Sequence

Protein

• Length: 293 a.a.
• Molecular weight: 31757.50 Da
• Isoelectric Point: 10.1789

>NTDB_id=23970 STR_RS05490 WP_011226089.1 1020596..1021477(-) (endA) [Streptococcus thermophilus CNRZ1066]
MAKRKTSLTNKQKRQLVTLIIAALIAVLGYLGTSNKLSPDNPIRQVASLVAGKSNKSIKSNGSTNSQSTPQEQLAETVMT
SSVKSQLGNSLEWNGAGAYIINRNKTNLNAKVSSQPYANNQVKTVQGQTVPTVANALLSKATRQYKNRQETGNGSTSWTP
AGWHQVQNLSGEYSHAVDRGHLLGYALIGGLKGFDASTSNPENIAVQTAWANQAYSDSSTGQNYYESLVRKALDKNKRVR
YRVTLIYEGENLIPSGTHLEAKSADGSLEFNVFVPNVQEGITLDYYSGKVTVN

Nucleotide

• Length: 882 bp

>NTDB_id=23970 STR_RS05490 WP_011226089.1 1020596..1021477(-) (endA) [Streptococcus thermophilus CNRZ1066]
ATGGCAAAAAGAAAGACATCTTTGACAAATAAACAGAAACGTCAGTTAGTCACATTAATAATAGCAGCTTTGATAGCTGT
TTTAGGTTACCTAGGAACCAGTAACAAGCTCTCGCCTGATAATCCTATCAGACAAGTAGCAAGCCTAGTTGCAGGGAAAT
CTAACAAATCCATTAAATCTAATGGTTCAACAAATAGTCAGTCTACACCACAAGAGCAGCTTGCTGAGACAGTAATGACT
AGTTCAGTCAAAAGCCAACTGGGTAATTCCTTGGAATGGAATGGAGCTGGGGCCTACATTATTAATAGAAATAAGACGAA
TCTAAATGCTAAGGTATCAAGCCAACCCTATGCTAATAACCAAGTCAAAACGGTTCAAGGACAAACTGTTCCTACAGTTG
CTAATGCCTTATTAAGTAAAGCAACTAGACAGTACAAAAATCGTCAAGAAACAGGGAATGGTTCAACCTCTTGGACACCA
GCTGGATGGCACCAGGTTCAAAATTTATCAGGAGAGTATAGCCATGCCGTAGATAGAGGCCATTTGCTAGGTTATGCACT
GATAGGTGGTTTGAAAGGATTTGATGCCTCGACTTCAAATCCAGAGAATATTGCTGTTCAAACTGCTTGGGCAAATCAAG
CATATAGCGATAGTTCTACAGGCCAAAACTATTATGAAAGCCTAGTACGAAAAGCCCTGGATAAAAACAAACGTGTTCGT
TATCGTGTGACCCTGATTTATGAAGGAGAGAATCTCATTCCATCAGGAACACATCTTGAAGCTAAGTCAGCAGACGGCTC
ACTTGAGTTTAATGTCTTTGTTCCAAATGTACAAGAGGGAATTACACTAGATTACTATTCAGGAAAAGTAACGGTGAATT
GA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (101-266)

3D structure

• AlphaFold DB: Q5M441

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	72.803	81.57	0.594
endA	Streptococcus pneumoniae D39	72.803	81.57	0.594
endA	Streptococcus pneumoniae R6	72.803	81.57	0.594
endA	Streptococcus pneumoniae TIGR4	72.803	81.57	0.594