Detailed information NTG0225249

Bioinformatically predicted

Overview

• Name: comB4
• Type: Machinery gene
• Locus tag: C2842_RS02375
• Genome accession: NZ_CP026324
• Coordinates: 476382..478958 (+)
• Length: 858 a.a.
• NCBI ID: WP_000893960.1
• Uniprot ID: O25206
• Organism: Helicobacter pylori strain 26695-dRdM2
• Function: transformation-associated type IV transport system (predicted from homology) DNA binding and uptake

Genomic Context

Location: 471382..483958

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C2842_RS02340 (C2842_02350)	-	473440..474108 (+)	669	WP_001862498.1	AAA family ATPase	-
C2842_RS02345 (C2842_02355)	-	474086..474873 (+)	788	Protein_435	integrase	-
C2842_RS02350 (C2842_02360)	-	474876..475106 (+)	231	WP_000189081.1	hypothetical protein	-
C2842_RS02355 (C2842_02365)	-	475099..475578 (+)	480	WP_000593414.1	hypothetical protein	-
C2842_RS02360 (C2842_02370)	comB2	475575..475859 (+)	285	WP_000736478.1	TrbC/VirB2 family protein	Machinery gene
C2842_RS02365 (C2842_02375)	comB3	475871..476134 (+)	264	WP_001177716.1	hypothetical protein	Machinery gene
C2842_RS02370 (C2842_02380)	-	476146..476382 (+)	237	WP_001168532.1	hypothetical protein	-
C2842_RS02375 (C2842_02385)	comB4	476382..478958 (+)	2577	WP_000893960.1	VirB4 family type IV secretion/conjugal transfer ATPase	Machinery gene
C2842_RS08390 (C2842_02390)	-	478955..479095 (+)	141	WP_000789926.1	hypothetical protein	-
C2842_RS02385 (C2842_02395)	-	479088..479573 (+)	486	Protein_443	hypothetical protein	-
C2842_RS02390 (C2842_02400)	-	480107..481204 (-)	1098	WP_000005927.1	restriction endonuclease subunit S	-
C2842_RS02400 (C2842_02410)	-	481197..482827 (-)	1631	Protein_445	N-6 DNA methylase	-

Sequence

Protein

• Length: 858 a.a.
• Molecular weight: 98509.67 Da
• Isoelectric Point: 8.9725

>NTDB_id=225249 C2842_RS02375 WP_000893960.1 476382..478958(+) (comB4) [Helicobacter pylori strain 26695-dRdM2]
MLESALKYCKEKAIDLLVGFVPKTYSMAQECNILGLYDDAFIITKQENLVGIISLQGLSYSNLMQKDLEGYFDARQNVLN
TISKDIQLRIVAKRRKEFINQSPNIDNIYAKAIITQFESKGIYKTEYFLVFETITSNVKSFFEKKKLEMTTSINEELEES
SKEDKQENENSSNETHSNTSSKKDKKNKFKKKITFSTKSKRALLIQTIERVKNALKEFKPTLLNSKEVLNFYAEYINGKY
IAFNPKLKRLSDSYIASNVHFKKDYFVIEFQNQNTFCACVGIKAYESEEISSLPISTLLHTQIELDLIFHIRSLGQFESL
NFLKTKKKLTLSKIVKADIDNYIELVQANRLSMQECALNLVIRAKSKAKLDKSLKEILSLLNNAGLGSVTETIGLKPSYF
SFFPNNANINPRMRHQTSQVIASLILFEKNNTGFRANSWGDMPLSVFKNLDHSPYLFNFHNQEVKHKGVLAHNVARVVGH
TMIIGATGAGKTTLISYLMMSALKYSNIDILALDRLNGLYSFTKYFDGIYNQGENFHINPFSLEDSATNRAFLLHFYAQM
AKVDSYDDHKDKVEDRTALLNAIDTMYRNYNDEVKQAKFSNQELPLPFDLKEFVNAIAKTNTDILDSSFEDYLKSSLFSS
RMDSLDFKTRISTINTDSILHNDDDAGLLAYYVFHKMIDRALKINRGFLCFIDEFKSYAQNEMMNKKINEIITQARKANG
VIVLALQDINQLSEVRNAQSFIKNMGQLILYPQRNIDTKDLNDKFGIRLSDTEKHFLENTAVNEYKVLLKNMNDGSSNII
DVSLSSLGNYLQIFSSNSSMVEHIDNLIKHYPKTWREVFVSNKHENFDDKKHLEKVLK

Nucleotide

• Length: 2577 bp

>NTDB_id=225249 C2842_RS02375 WP_000893960.1 476382..478958(+) (comB4) [Helicobacter pylori strain 26695-dRdM2]
ATGTTAGAAAGCGCCCTTAAATATTGCAAGGAAAAAGCCATAGACCTTTTAGTAGGGTTTGTGCCAAAAACCTATTCTAT
GGCACAAGAGTGCAATATTTTAGGCTTGTATGATGATGCTTTCATTATTACCAAACAAGAAAATCTAGTAGGCATTATAT
CCTTACAAGGACTAAGCTATTCTAATTTAATGCAAAAAGACTTAGAGGGCTATTTTGATGCTAGACAAAATGTTCTCAAC
ACCATTAGTAAAGACATTCAATTAAGAATTGTGGCTAAAAGGCGTAAGGAATTTATCAATCAAAGTCCAAATATTGACAA
TATTTATGCCAAAGCTATTATCACACAATTTGAAAGCAAGGGAATCTATAAAACAGAGTATTTTTTAGTGTTTGAAACTA
TCACTTCTAATGTCAAGTCTTTCTTTGAAAAAAAGAAATTGGAAATGACTACTTCAATTAATGAAGAGTTAGAAGAAAGC
TCTAAAGAAGATAAACAAGAGAATGAAAATAGCTCCAATGAAACTCATTCAAACACAAGCTCTAAAAAAGACAAGAAAAA
CAAGTTCAAAAAAAAGATAACCTTTAGCACCAAAAGTAAAAGAGCCTTACTCATTCAAACCATAGAAAGAGTAAAAAACG
CTCTTAAAGAATTTAAACCCACTTTACTAAATTCTAAAGAAGTATTAAATTTCTACGCAGAATACATCAATGGCAAATAC
ATCGCCTTTAATCCTAAATTAAAGCGATTAAGCGATAGCTATATTGCATCTAATGTGCATTTTAAGAAAGATTACTTTGT
CATTGAATTTCAAAATCAAAACACCTTTTGTGCGTGTGTGGGGATTAAGGCTTATGAGAGCGAAGAAATTTCTTCGCTCC
CTATATCTACTCTTTTACACACCCAAATTGAACTAGATTTAATCTTTCATATCCGCTCTTTAGGGCAATTTGAAAGCCTG
AATTTTTTAAAAACTAAGAAAAAGCTCACGCTTTCTAAAATAGTAAAAGCTGATATTGATAATTATATAGAATTAGTGCA
AGCCAATCGTTTGAGCATGCAAGAGTGTGCTTTAAACTTAGTTATAAGGGCTAAAAGTAAAGCTAAATTAGACAAGTCTT
TAAAAGAGATTTTATCCTTGCTTAATAATGCTGGACTAGGCAGTGTTACAGAAACTATAGGGCTAAAACCATCTTATTTT
TCATTCTTCCCAAATAACGCCAATATCAACCCTAGAATGAGACATCAAACTTCCCAAGTCATAGCATCTTTGATTTTGTT
TGAGAAAAATAATACAGGTTTTAGAGCAAATTCTTGGGGGGATATGCCCTTATCTGTGTTTAAGAACCTAGACCATAGCC
CTTATTTGTTTAATTTTCATAATCAAGAAGTCAAACATAAGGGCGTGTTAGCCCACAATGTCGCACGAGTAGTGGGACAT
ACCATGATTATAGGAGCAACAGGTGCTGGTAAAACCACACTCATTAGCTATTTGATGATGAGTGCCTTAAAATATTCTAA
CATTGATATTTTAGCTCTTGATAGACTAAATGGTTTGTATTCCTTTACCAAGTATTTTGATGGGATTTATAATCAAGGCG
AAAACTTTCATATTAACCCTTTTTCATTAGAAGATAGCGCAACTAATAGAGCCTTTTTATTGCATTTTTATGCCCAAATG
GCAAAAGTGGATAGTTATGATGACCATAAGGATAAAGTAGAAGATAGAACAGCCCTTTTAAATGCTATTGATACGATGTA
TAGAAATTATAACGATGAAGTCAAACAAGCCAAATTTAGCAACCAAGAATTACCCCTTCCTTTTGATTTAAAAGAGTTTG
TCAATGCCATTGCTAAAACCAATACAGACATTTTAGATAGTAGTTTTGAAGACTATTTAAAATCTTCCTTATTTTCTAGC
CGAATGGATAGTCTAGATTTTAAAACTCGTATTAGCACCATAAATACCGATAGCATTTTACATAATGATGATGACGCTGG
GCTTTTAGCCTACTATGTCTTTCATAAGATGATTGACAGAGCCTTAAAAATCAATCGTGGGTTTTTATGCTTTATTGATG
AGTTTAAGTCTTACGCTCAAAATGAAATGATGAATAAAAAAATCAATGAAATCATTACTCAAGCTAGAAAGGCTAATGGG
GTGATTGTTCTAGCCTTACAAGACATTAACCAACTAAGCGAAGTGAGAAACGCTCAAAGCTTTATAAAAAATATGGGGCA
ATTGATTTTGTATCCCCAAAGAAATATTGATACCAAAGATTTAAACGATAAATTTGGCATTAGACTAAGCGATACAGAAA
AACATTTTTTAGAAAACACCGCCGTTAATGAATACAAAGTCTTACTCAAAAACATGAATGATGGCTCATCTAACATTATA
GATGTGAGCCTAAGTTCTTTGGGTAATTACCTACAAATCTTTAGCTCTAATTCTAGCATGGTAGAACACATTGATAATCT
CATTAAGCATTACCCTAAAACTTGGCGAGAAGTCTTTGTGAGTAACAAACACGAAAATTTTGATGACAAAAAACACTTAG
AAAAGGTGCTTAAATGA

Domains

Predicted by InterProScan.

• FtsK/SpoIIIE family (FtsK_SpoIIIE) (437-505)

• CagE, TrbE, VirB family, component of type IV transporter system (CagE_TrbE_VirB) (214-412)

3D structure

• AlphaFold DB: O25206

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comB4	Helicobacter pylori 26695	46.667	97.902	0.457