Detailed information NTG0021566

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPR_RS08950
• Genome accession: NC_003098
• Coordinates: 1756515..1757552 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae R6
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1751515..1762552

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPR_RS08925 (spr1778)	-	1752316..1753647 (-)	1332	WP_000390046.1	hemolysin family protein	-
SPR_RS08930 (spr1779)	endA	1753876..1754700 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
SPR_RS08935 (spr1780)	-	1754739..1754927 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
SPR_RS08940 (spr1781)	murA	1754920..1756203 (-)	1284	WP_000358027.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SPR_RS08945 (spr1781a)	-	1756227..1756457 (-)	231	WP_000250384.1	DUF1146 family protein	-
SPR_RS08950 (spr1782)	sepM	1756515..1757552 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
SPR_RS08955 (spr1783)	coaD	1757536..1758024 (-)	489	WP_001280727.1	pantetheine-phosphate adenylyltransferase	-
SPR_RS08960 (spr1784)	rsmD	1758014..1758553 (-)	540	WP_000706962.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPR_RS08965 (spr1785)	asnA	1758618..1759610 (-)	993	WP_000747995.1	aspartate--ammonia ligase	-
SPR_RS08970 (spr1787)	-	1759722..1760405 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
SPR_RS08975 (spr1788)	-	1760461..1761201 (-)	741	WP_000152673.1	TrmH family RNA methyltransferase	-
SPR_RS08980 (spr1789)	-	1761235..1761513 (+)	279	WP_001174613.1	acylphosphatase	-
SPR_RS08985 (spr1790)	yidC	1761591..1762517 (+)	927	WP_000835947.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=21566 SPR_RS08950 WP_000727277.1 1756515..1757552(-) (sepM) [Streptococcus pneumoniae R6]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=21566 SPR_RS08950 WP_000727277.1 1756515..1757552(-) (sepM) [Streptococcus pneumoniae R6]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGCATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591