Detailed information NTG0192965

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: A7U52_RS11905
• Genome accession: NZ_CP016861
• Coordinates: 2216862..2217905 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 1969.N
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2211862..2222905

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7U52_RS11860 (A7U52_04615)	-	2212232..2212342 (+)	111	WP_001790257.1	hypothetical protein	-
A7U52_RS11865 (A7U52_0863)	-	2212371..2212784 (+)	414	WP_001549145.1	hypothetical protein	-
A7U52_RS11875 (A7U52_0864)	-	2213274..2214260 (-)	987	WP_000999713.1	FUSC family protein	-
A7U52_RS11890 (A7U52_0865)	map	2214788..2215546 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
A7U52_RS11895 (A7U52_0866)	-	2215763..2216149 (+)	387	WP_001110179.1	hypothetical protein	-
A7U52_RS11900 (A7U52_0867)	liaF	2216164..2216865 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
A7U52_RS11905 (A7U52_0868)	vraS	2216862..2217905 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
A7U52_RS11910 (A7U52_0869)	vraR	2217895..2218524 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
A7U52_RS11915 (A7U52_0870)	-	2218640..2219857 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
A7U52_RS11920 (A7U52_0871)	-	2220135..2220410 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
A7U52_RS11925 (A7U52_0872)	-	2220417..2220881 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
A7U52_RS11930 (A7U52_0873)	-	2221028..2221228 (+)	201	WP_000180461.1	DUF1128 family protein	-
A7U52_RS11935 (A7U52_0874)	-	2221231..2222487 (+)	1257	WP_078149050.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=192965 A7U52_RS11905 WP_001017131.1 2216862..2217905(+) (vraS) [Staphylococcus aureus strain 1969.N]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=192965 A7U52_RS11905 WP_001017131.1 2216862..2217905(+) (vraS) [Staphylococcus aureus strain 1969.N]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1