Detailed information    

insolico Bioinformatically predicted

Overview

Name   codY   Type   Regulator
Locus tag   AXW78_RS18135 Genome accession   NZ_CP014282
Coordinates   3672639..3673418 (-) Length   259 a.a.
NCBI ID   WP_000421290.1    Uniprot ID   A0A9W5VKA1
Organism   Bacillus thuringiensis strain Bt185     
Function   repression of comK (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 3657194..3712284 3672639..3673418 within 0


Gene organization within MGE regions


Location: 3657194..3712284
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AXW78_RS18080 (AXW78_18080) rimP 3658096..3658566 (-) 471 WP_000359096.1 ribosome maturation factor RimP -
  AXW78_RS18085 (AXW78_18085) - 3658903..3663204 (-) 4302 WP_000060003.1 PolC-type DNA polymerase III -
  AXW78_RS18090 (AXW78_18090) - 3663329..3665029 (-) 1701 WP_000814290.1 proline--tRNA ligase -
  AXW78_RS18095 (AXW78_18095) rseP 3665139..3666395 (-) 1257 WP_001090243.1 RIP metalloprotease RseP -
  AXW78_RS18100 (AXW78_18100) dxr 3666413..3667555 (-) 1143 WP_061884512.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
  AXW78_RS18105 (AXW78_18105) cdsA 3667579..3668370 (-) 792 WP_000813592.1 phosphatidate cytidylyltransferase -
  AXW78_RS18110 (AXW78_18110) uppS 3668388..3669164 (-) 777 WP_000971296.1 isoprenyl transferase -
  AXW78_RS18115 (AXW78_18115) frr 3669250..3669807 (-) 558 WP_000531501.1 ribosome recycling factor -
  AXW78_RS18120 (AXW78_18120) pyrH 3669810..3670532 (-) 723 WP_000042668.1 UMP kinase -
  AXW78_RS18125 (AXW78_18125) tsf 3670599..3671486 (-) 888 WP_001018578.1 translation elongation factor Ts -
  AXW78_RS18130 (AXW78_18130) rpsB 3671590..3672291 (-) 702 WP_000111485.1 30S ribosomal protein S2 -
  AXW78_RS18135 (AXW78_18135) codY 3672639..3673418 (-) 780 WP_000421290.1 GTP-sensing pleiotropic transcriptional regulator CodY Regulator
  AXW78_RS18140 (AXW78_18140) hslU 3673496..3674887 (-) 1392 WP_000550078.1 ATP-dependent protease ATPase subunit HslU -
  AXW78_RS18145 (AXW78_18145) hslV 3674910..3675452 (-) 543 WP_000526272.1 ATP-dependent protease proteolytic subunit HslV -
  AXW78_RS18150 (AXW78_18150) xerC 3675495..3676394 (-) 900 WP_001101242.1 tyrosine recombinase XerC -
  AXW78_RS18155 (AXW78_18155) trmFO 3676460..3677764 (-) 1305 WP_000213002.1 FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO -
  AXW78_RS18160 (AXW78_18160) topA 3677813..3679891 (-) 2079 WP_001286963.1 type I DNA topoisomerase -
  AXW78_RS18165 (AXW78_18165) dprA 3680036..3680905 (-) 870 WP_000818040.1 DNA-processing protein DprA -
  AXW78_RS18170 (AXW78_18170) sucD 3680993..3681895 (-) 903 WP_000115178.1 succinate--CoA ligase subunit alpha -
  AXW78_RS18175 (AXW78_18175) sucC 3681915..3683075 (-) 1161 WP_061884513.1 ADP-forming succinate--CoA ligase subunit beta -
  AXW78_RS18180 (AXW78_18180) - 3683270..3684043 (-) 774 WP_001194265.1 ribonuclease HII -
  AXW78_RS18185 (AXW78_18185) ylqF 3684100..3684990 (-) 891 WP_000236702.1 ribosome biogenesis GTPase YlqF -
  AXW78_RS18190 (AXW78_18190) lepB 3685011..3685562 (-) 552 WP_000711853.1 signal peptidase I -
  AXW78_RS18195 (AXW78_18195) rplS 3685664..3686008 (-) 345 WP_001186516.1 50S ribosomal protein L19 -
  AXW78_RS18200 (AXW78_18200) trmD 3686155..3686889 (-) 735 WP_061884514.1 tRNA (guanosine(37)-N1)-methyltransferase TrmD -
  AXW78_RS18205 (AXW78_18205) rimM 3686889..3687404 (-) 516 WP_000170278.1 ribosome maturation factor RimM -
  AXW78_RS18210 (AXW78_18210) - 3687525..3687752 (-) 228 WP_000737401.1 KH domain-containing protein -
  AXW78_RS18215 (AXW78_18215) rpsP 3687767..3688039 (-) 273 WP_000268750.1 30S ribosomal protein S16 -
  AXW78_RS18220 (AXW78_18220) ffh 3688141..3689490 (-) 1350 WP_000863460.1 signal recognition particle protein -
  AXW78_RS18225 (AXW78_18225) - 3689503..3689835 (-) 333 WP_000891062.1 putative DNA-binding protein -
  AXW78_RS18230 (AXW78_18230) ftsY 3689969..3690958 (-) 990 WP_000007655.1 signal recognition particle-docking protein FtsY -
  AXW78_RS18235 (AXW78_18235) smc 3690974..3694543 (-) 3570 WP_000478969.1 chromosome segregation protein SMC -
  AXW78_RS18240 (AXW78_18240) rncS 3694690..3695427 (-) 738 WP_001146875.1 ribonuclease III -
  AXW78_RS18245 (AXW78_18245) acpP 3695487..3695720 (-) 234 WP_000786062.1 acyl carrier protein -
  AXW78_RS18250 (AXW78_18250) fabG 3695790..3696530 (-) 741 WP_000911771.1 3-oxoacyl-[acyl-carrier-protein] reductase -
  AXW78_RS18255 (AXW78_18255) fabD 3696530..3697474 (-) 945 WP_061884515.1 ACP S-malonyltransferase -
  AXW78_RS18260 (AXW78_18260) plsX 3697489..3698481 (-) 993 WP_000684100.1 phosphate acyltransferase PlsX -
  AXW78_RS18265 (AXW78_18265) fapR 3698478..3699071 (-) 594 WP_000747349.1 transcription factor FapR -
  AXW78_RS18270 (AXW78_18270) recG 3699160..3701208 (-) 2049 WP_001000812.1 ATP-dependent DNA helicase RecG -
  AXW78_RS18275 (AXW78_18275) - 3701499..3703175 (-) 1677 WP_000027129.1 DAK2 domain-containing protein -
  AXW78_RS18280 (AXW78_18280) - 3703198..3703560 (-) 363 WP_000021109.1 Asp23/Gls24 family envelope stress response protein -
  AXW78_RS18285 (AXW78_18285) rpmB 3703937..3704125 (+) 189 WP_000124776.1 50S ribosomal protein L28 -
  AXW78_RS18290 (AXW78_18290) spoVM 3704199..3704279 (-) 81 WP_001213599.1 stage V sporulation protein SpoVM -
  AXW78_RS18295 (AXW78_18295) - 3704346..3705026 (-) 681 WP_000752664.1 thiamine diphosphokinase -
  AXW78_RS18300 (AXW78_18300) rpe 3705096..3705740 (-) 645 WP_000589974.1 ribulose-phosphate 3-epimerase -
  AXW78_RS18305 (AXW78_18305) rsgA 3705743..3706624 (-) 882 WP_001113932.1 ribosome small subunit-dependent GTPase A -
  AXW78_RS18310 (AXW78_18310) pknB 3706896..3708869 (-) 1974 WP_000904754.1 Stk1 family PASTA domain-containing Ser/Thr kinase -
  AXW78_RS18315 (AXW78_18315) - 3708878..3709630 (-) 753 WP_000648704.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  AXW78_RS18320 (AXW78_18320) rlmN 3709635..3710723 (-) 1089 WP_000450541.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  AXW78_RS18325 (AXW78_18325) rsmB 3710728..3712062 (-) 1335 WP_001249684.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -

Sequence

Protein


Download         Length: 259 a.a.        Molecular weight: 28793.05 Da        Isoelectric Point: 4.7165

>NTDB_id=170195 AXW78_RS18135 WP_000421290.1 3672639..3673418(-) (codY) [Bacillus thuringiensis strain Bt185]
MELLAKTRKLNALLQSAAGKPVNFREMSDTMCEVIEANVFVVSRRGKLLGYAIHQQIENERMKQMLAERQFPEEYTQSLF
NITETSSNLDVNSAYTAFPVENRELFGQGLTTIVPIVGGGERLGTLVLARLGQEFLDDDLILAEYSSTVVGMEILREKAE
EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELNGTEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKGT
YIKVLNDKFLQELAKLKTN

Nucleotide


Download         Length: 780 bp        

>NTDB_id=170195 AXW78_RS18135 WP_000421290.1 3672639..3673418(-) (codY) [Bacillus thuringiensis strain Bt185]
ATGGAATTATTAGCAAAAACGAGAAAATTAAATGCGTTATTACAGAGCGCAGCAGGGAAGCCTGTAAACTTTAGAGAAAT
GTCTGACACAATGTGTGAAGTAATCGAAGCAAACGTATTCGTAGTTAGCCGTCGTGGTAAATTACTAGGTTATGCAATTC
ACCAACAAATCGAAAACGAACGCATGAAGCAAATGCTTGCAGAACGTCAATTCCCAGAAGAATATACACAAAGCTTATTC
AACATTACAGAAACATCTTCAAACTTAGATGTGAACAGTGCTTACACAGCATTCCCAGTAGAAAACAGAGAATTATTTGG
TCAAGGTTTAACTACAATCGTACCAATCGTTGGTGGCGGTGAGCGTCTAGGTACATTAGTATTAGCTCGTCTTGGTCAAG
AGTTCTTAGATGATGATTTAATCCTTGCTGAGTACAGCTCAACTGTTGTAGGTATGGAAATCTTGCGTGAAAAAGCAGAA
GAAATTGAAGAGGAAGCACGTAGTAAAGCTGTTGTTCAAATGGCGATCAGCTCATTATCTTACAGTGAGTTAGAAGCAAT
TGAGCACATCTTCGAAGAATTAAATGGAACAGAAGGTTTACTTGTTGCAAGTAAAATTGCTGATCGCGTAGGAATTACTC
GTTCTGTAATCGTAAATGCACTACGTAAATTAGAAAGTGCTGGTGTTATTGAGTCTCGTTCTTTAGGTATGAAAGGAACA
TACATTAAAGTGCTAAACGACAAGTTTCTACAGGAACTTGCTAAATTAAAAACAAACTAA

Domains

Predicted by InterproScan.

CodY GAF-like domain (CodY)

(2-178)

CodY helix-turn-helix domain (HTH_CodY)

(198-255)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  codY Bacillus subtilis subsp. subtilis str. 168

81.467

100

0.815
  codY Lactococcus lactis subsp. lactis strain DGCC12653

46.667

98.456

0.459

Multiple sequence alignment