Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   MGAS23530_RS01225 Genome accession   NZ_CP013839
Coordinates   236846..237607 (+) Length   253 a.a.
NCBI ID   WP_002986029.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain MGAS23530     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 231846..242607
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS23530_RS01210 (MGAS23530_0255) - 232104..233672 (-) 1569 WP_031488671.1 ABC transporter substrate-binding protein/permease -
  MGAS23530_RS01215 (MGAS23530_0256) - 233870..235795 (+) 1926 WP_031488670.1 DUF2207 domain-containing protein -
  MGAS23530_RS01220 (MGAS23530_0257) - 235861..236700 (+) 840 WP_031488669.1 undecaprenyl-diphosphate phosphatase -
  MGAS23530_RS01225 (MGAS23530_0258) mecA 236846..237607 (+) 762 WP_002986029.1 adaptor protein MecA Regulator
  MGAS23530_RS01230 (MGAS23530_0259) - 237614..238783 (+) 1170 WP_002991122.1 glycosyltransferase family 4 protein -
  MGAS23530_RS01235 (MGAS23530_0260) sufC 238905..239675 (+) 771 WP_031488668.1 Fe-S cluster assembly ATPase SufC -
  MGAS23530_RS01240 (MGAS23530_0261) sufD 239770..241032 (+) 1263 WP_031488667.1 Fe-S cluster assembly protein SufD -
  MGAS23530_RS01245 (MGAS23530_0262) - 241063..242289 (+) 1227 WP_011054183.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29051.72 Da        Isoelectric Point: 4.1622

>NTDB_id=165052 MGAS23530_RS01225 WP_002986029.1 236846..237607(+) (mecA) [Streptococcus pyogenes strain MGAS23530]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=165052 MGAS23530_RS01225 WP_002986029.1 236846..237607(+) (mecA) [Streptococcus pyogenes strain MGAS23530]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.235

100

0.486
  mecA Streptococcus pneumoniae D39

48.235

100

0.486
  mecA Streptococcus pneumoniae R6

48.235

100

0.486
  mecA Streptococcus pneumoniae TIGR4

48.235

100

0.486

Multiple sequence alignment