Detailed information NTG0160288

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: BAY21_RS06685
• Genome accession: NZ_CP016439
• Coordinates: 1250020..1250805 (+)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain CS8
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1245020..1255805

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BAY21_RS06660 (BAY21_06660)	pflA	1245296..1246096 (+)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-
BAY21_RS06665 (BAY21_06665)	-	1246302..1246772 (+)	471	WP_011227497.1	membrane protein	-
BAY21_RS09980	-	1246988..1247559 (-)	572	Protein_1245	IS30 family transposase	-
BAY21_RS06675 (BAY21_06675)	-	1247739..1248191 (-)	453	WP_002946987.1	universal stress protein	-
BAY21_RS06680 (BAY21_06680)	-	1248546..1249760 (+)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
BAY21_RS06685 (BAY21_06685)	codY	1250020..1250805 (+)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
BAY21_RS06690 (BAY21_06690)	-	1250868..1251419 (+)	552	WP_002946999.1	cysteine hydrolase family protein	-
BAY21_RS06695 (BAY21_06695)	-	1251542..1252390 (+)	849	WP_065429507.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
BAY21_RS06700 (BAY21_06700)	msrA	1252402..1252911 (+)	510	WP_041827089.1	peptide-methionine (S)-S-oxide reductase MsrA	-
BAY21_RS06705 (BAY21_06705)	-	1253064..1254505 (+)	1442	Protein_1252	6-phospho-beta-glucosidase	-
BAY21_RS09985	-	1254833..1255030 (+)	198	WP_231108739.1	glycosyltransferase	-
BAY21_RS06710 (BAY21_06710)	-	1255043..1255297 (+)	255	WP_011226449.1	glycosyl transferase	-
BAY21_RS06715 (BAY21_06715)	gatC	1255437..1255739 (+)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=160288 BAY21_RS06685 WP_002951720.1 1250020..1250805(+) (codY) [Streptococcus thermophilus strain CS8]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=160288 BAY21_RS06685 WP_002951720.1 1250020..1250805(+) (codY) [Streptococcus thermophilus strain CS8]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502