Detailed information    

insolico Bioinformatically predicted

Overview

Name   endA   Type   Machinery gene
Locus tag   SanJ4206_RS03315 Genome accession   NZ_CP012719
Coordinates   675104..675949 (+) Length   281 a.a.
NCBI ID   WP_003028076.1    Uniprot ID   A0AAI9J6A1
Organism   Streptococcus anginosus strain J4206     
Function   cleavage of dsDNA into ssDNA (predicted from homology)   
DNA processing

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 626120..680416 675104..675949 within 0


Gene organization within MGE regions


Location: 626120..680416
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SanJ4206_RS03095 (SanJ4206_0580c) fbp62 626505..628154 (-) 1650 WP_022525450.1 Rqc2 family fibronectin-binding protein Fbp62 -
  SanJ4206_RS03100 (SanJ4206_0581) trpX 628641..629645 (+) 1005 WP_003028040.1 tryptophan ABC transporter substrate-binding protein -
  SanJ4206_RS03105 (SanJ4206_0582) - 629678..630544 (+) 867 WP_003028041.1 ABC transporter permease -
  SanJ4206_RS03110 (SanJ4206_0583) - 630541..631299 (+) 759 WP_003028043.1 ABC transporter ATP-binding protein -
  SanJ4206_RS03115 - 631315..631656 (-) 342 WP_003028044.1 hypothetical protein -
  SanJ4206_RS03120 (SanJ4206_0584) - 631744..631956 (+) 213 WP_003028046.1 YdbC family protein -
  SanJ4206_RS03125 (SanJ4206_0585) - 632158..633051 (+) 894 WP_003028047.1 ABC transporter ATP-binding protein -
  SanJ4206_RS03130 (SanJ4206_0586) - 633048..634262 (+) 1215 WP_003028048.1 ABC transporter permease -
  SanJ4206_RS03135 (SanJ4206_0587) rexB 634383..637655 (+) 3273 WP_022525449.1 ATP-dependent nuclease subunit B -
  SanJ4206_RS03140 (SanJ4206_0588) addA 637652..641332 (+) 3681 WP_022525448.1 helicase-exonuclease AddAB subunit AddA -
  SanJ4206_RS03145 (SanJ4206_0589c) - 641808..643025 (-) 1218 WP_006906966.1 site-specific integrase -
  SanJ4206_RS03150 (SanJ4206_0590c) - 643108..643311 (-) 204 WP_006906967.1 excisionase -
  SanJ4206_RS03155 (SanJ4206_0592c) - 643766..643996 (-) 231 WP_006906968.1 helix-turn-helix domain-containing protein -
  SanJ4206_RS03160 (SanJ4206_0593c) - 643993..644415 (-) 423 WP_006906969.1 RNA polymerase sigma factor -
  SanJ4206_RS03165 - 644754..644942 (-) 189 WP_080660607.1 cysteine-rich KTR domain-containing protein -
  SanJ4206_RS03170 (SanJ4206_0594c) - 644948..645982 (-) 1035 WP_006906970.1 alpha/beta fold hydrolase -
  SanJ4206_RS03175 (SanJ4206_0595c) - 646017..646655 (-) 639 WP_006906971.1 TetR/AcrR family transcriptional regulator -
  SanJ4206_RS03180 (SanJ4206_0596c) - 646775..647686 (-) 912 WP_006906972.1 conjugal transfer protein -
  SanJ4206_RS03185 (SanJ4206_0597c) - 647701..648702 (-) 1002 WP_006906973.1 lysozyme family protein -
  SanJ4206_RS03190 (SanJ4206_0598c) - 648699..650774 (-) 2076 WP_022525063.1 FUSC family protein -
  SanJ4206_RS03195 (SanJ4206_0599c) - 650777..653224 (-) 2448 WP_006906975.1 ATP-binding protein -
  SanJ4206_RS03200 - 653208..653600 (-) 393 WP_006906976.1 conjugal transfer protein -
  SanJ4206_RS03205 (SanJ4206_0601c) - 653685..654182 (-) 498 WP_006906977.1 antirestriction protein ArdA -
  SanJ4206_RS03210 (SanJ4206_0602c) - 654198..654419 (-) 222 WP_006906978.1 hypothetical protein -
  SanJ4206_RS03215 (SanJ4206_0603c) mobT 654458..655639 (-) 1182 WP_418346449.1 MobT family relaxase -
  SanJ4206_RS03220 (SanJ4206_0604c) - 655850..657226 (-) 1377 WP_022525061.1 FtsK/SpoIIIE domain-containing protein -
  SanJ4206_RS03225 (SanJ4206_0605c) - 657262..657642 (-) 381 WP_006906982.1 YdcP family protein -
  SanJ4206_RS03230 (SanJ4206_0606c) - 657659..657973 (-) 315 WP_037593289.1 YdcP family protein -
  SanJ4206_RS03235 (SanJ4206_0607) glgB 658529..660439 (+) 1911 WP_003028051.1 1,4-alpha-glucan branching protein GlgB -
  SanJ4206_RS03240 (SanJ4206_0608) - 660443..661585 (+) 1143 WP_003028052.1 glucose-1-phosphate adenylyltransferase -
  SanJ4206_RS03245 (SanJ4206_0609) glgD 661575..662714 (+) 1140 WP_003028053.1 glucose-1-phosphate adenylyltransferase subunit GlgD -
  SanJ4206_RS03250 (SanJ4206_0610) glgA 662711..664141 (+) 1431 WP_003028054.1 glycogen synthase GlgA -
  SanJ4206_RS03255 (SanJ4206_0611) - 664166..666562 (+) 2397 WP_003028055.1 glycogen/starch/alpha-glucan phosphorylase -
  SanJ4206_RS03260 (SanJ4206_0612) - 666894..667094 (+) 201 WP_003025282.1 F0F1 ATP synthase subunit C -
  SanJ4206_RS03265 (SanJ4206_0613) atpB 667134..667847 (+) 714 WP_003028057.1 F0F1 ATP synthase subunit A -
  SanJ4206_RS03270 (SanJ4206_0614) atpF 667862..668356 (+) 495 WP_003028058.1 F0F1 ATP synthase subunit B -
  SanJ4206_RS03275 (SanJ4206_0615) - 668356..668892 (+) 537 WP_003028060.1 F0F1 ATP synthase subunit delta -
  SanJ4206_RS03280 (SanJ4206_0616) atpA 668908..670413 (+) 1506 WP_003028061.1 F0F1 ATP synthase subunit alpha -
  SanJ4206_RS03285 (SanJ4206_0617) - 670429..671307 (+) 879 WP_003028065.1 F0F1 ATP synthase subunit gamma -
  SanJ4206_RS03290 (SanJ4206_0618) atpD 671342..672748 (+) 1407 WP_003025268.1 F0F1 ATP synthase subunit beta -
  SanJ4206_RS03295 (SanJ4206_0619) - 672759..673178 (+) 420 WP_003028068.1 F0F1 ATP synthase subunit epsilon -
  SanJ4206_RS03300 (SanJ4206_0620) - 673287..673517 (+) 231 WP_018543445.1 DUF1146 family protein -
  SanJ4206_RS03305 (SanJ4206_0621) murA 673556..674836 (+) 1281 WP_003028071.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
  SanJ4206_RS03310 (SanJ4206_0622) - 674829..675005 (+) 177 WP_003028073.1 DNA-directed RNA polymerase subunit beta -
  SanJ4206_RS03315 (SanJ4206_0623) endA 675104..675949 (+) 846 WP_003028076.1 DNA/RNA non-specific endonuclease Machinery gene
  SanJ4206_RS03320 (SanJ4206_0624) - 676239..677978 (+) 1740 WP_003028078.1 ABC transporter ATP-binding protein -
  SanJ4206_RS03325 (SanJ4206_0625) - 677993..679765 (+) 1773 WP_003028080.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 281 a.a.        Molecular weight: 30731.46 Da        Isoelectric Point: 10.5496

>NTDB_id=156775 SanJ4206_RS03315 WP_003028076.1 675104..675949(+) (endA) [Streptococcus anginosus strain J4206]
MARKKSNQKVAQSVAGLVIALVLALGGYSFSNHHGSTKPSDSTAINRSIRTNHAAPSQELAQSVLTESVKRQLKGKIEWN
GAGAFTINENKTTLDAKVASVPYADNKTKLVRGQTVPTVANALLSKTTRQYRSREETGNRSTTWTPAGWHQVKHLSGEYN
HAVDRGHLLGYALIGNLKGFDASTSNPKNIAVQTAWANQANTSHSTGQNFYETKVRKALDKNKRVRYRVTLIYANEQDLV
PVGSHIEAKSSDSSLEMNVFVPNVQTGLRLNYQTGEVTVTN

Nucleotide


Download         Length: 846 bp        

>NTDB_id=156775 SanJ4206_RS03315 WP_003028076.1 675104..675949(+) (endA) [Streptococcus anginosus strain J4206]
ATGGCGAGAAAGAAATCCAATCAGAAAGTAGCACAAAGTGTAGCTGGTTTGGTTATAGCACTGGTTCTTGCGCTGGGAGG
TTATTCTTTTAGCAATCATCATGGTAGTACGAAGCCTTCTGACAGCACTGCTATTAATCGAAGTATTCGAACGAATCATG
CAGCACCCAGTCAAGAATTAGCACAGAGTGTTTTGACAGAGTCCGTTAAACGGCAACTCAAAGGAAAGATTGAATGGAAT
GGGGCAGGAGCCTTCACAATCAATGAAAATAAAACAACATTGGATGCTAAAGTTGCAAGCGTTCCTTATGCGGATAATAA
GACTAAACTCGTCCGAGGTCAGACCGTTCCGACGGTTGCAAATGCTCTTTTATCCAAAACAACTCGCCAATATAGAAGTC
GTGAAGAAACAGGAAATCGCTCCACGACTTGGACGCCTGCTGGTTGGCATCAAGTCAAGCATTTATCAGGTGAATACAAC
CATGCAGTTGACCGAGGACATTTGTTGGGTTATGCTTTGATTGGTAACTTGAAAGGGTTTGATGCTTCGACCAGTAACCC
GAAAAATATAGCTGTGCAAACAGCTTGGGCTAATCAAGCAAATACTAGTCATTCTACGGGTCAAAATTTCTATGAAACAA
AGGTTCGCAAGGCACTAGACAAAAATAAACGAGTTCGGTATCGAGTGACTTTGATTTATGCCAATGAACAGGATTTAGTG
CCAGTTGGTTCGCATATTGAAGCTAAATCAAGCGATAGTAGCTTGGAAATGAATGTTTTTGTTCCCAACGTACAGACAGG
ACTTCGGCTAAATTATCAAACAGGAGAAGTGACCGTTACCAACTAG

Domains

Predicted by InterproScan.

DNA/RNA non-specific endonuclease (Endonuclease_NS)

(83-279)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  endA Streptococcus pneumoniae Rx1

76.106

80.427

0.612
  endA Streptococcus pneumoniae D39

76.106

80.427

0.612
  endA Streptococcus pneumoniae R6

76.106

80.427

0.612
  endA Streptococcus pneumoniae TIGR4

76.106

80.427

0.612

Multiple sequence alignment