Detailed information NTG0143246

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: AVT04_RS06845
• Genome accession: NZ_CP013939
• Coordinates: 1272711..1273496 (+)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S9
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1267711..1278496

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AVT04_RS06820 (AVT04_06820)	pflA	1267987..1268787 (+)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-
AVT04_RS06825 (AVT04_06825)	-	1268993..1269463 (+)	471	WP_011227497.1	membrane protein	-
AVT04_RS11240	-	1269679..1270250 (-)	572	Protein_1248	IS30 family transposase	-
AVT04_RS06835 (AVT04_06835)	-	1270430..1270882 (-)	453	WP_002946987.1	universal stress protein	-
AVT04_RS06840 (AVT04_06840)	-	1271237..1272451 (+)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
AVT04_RS06845 (AVT04_06845)	codY	1272711..1273496 (+)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
AVT04_RS06850 (AVT04_06850)	-	1273559..1274110 (+)	552	WP_002946999.1	cysteine hydrolase family protein	-
AVT04_RS06855 (AVT04_06855)	-	1274233..1275081 (+)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
AVT04_RS06860 (AVT04_06860)	msrA	1275093..1275602 (+)	510	WP_002946589.1	peptide-methionine (S)-S-oxide reductase MsrA	-
AVT04_RS06865 (AVT04_06865)	-	1275755..1277196 (+)	1442	Protein_1255	6-phospho-beta-glucosidase	-
AVT04_RS10040	-	1277560..1277721 (+)	162	WP_180473551.1	glycosyltransferase	-
AVT04_RS06870 (AVT04_06870)	-	1277734..1277988 (+)	255	WP_011226449.1	glycosyl transferase	-
AVT04_RS06875 (AVT04_06875)	gatC	1278128..1278430 (+)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=143246 AVT04_RS06845 WP_002951720.1 1272711..1273496(+) (codY) [Streptococcus thermophilus strain S9]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=143246 AVT04_RS06845 WP_002951720.1 1272711..1273496(+) (codY) [Streptococcus thermophilus strain S9]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502