Detailed information NTG0139583

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: AS852_RS06340
• Genome accession: NZ_CP013218
• Coordinates: 1256859..1257632 (+)
• Length: 257 a.a.
• NCBI ID: WP_000055337.1
• Uniprot ID: P63843
• Organism: Staphylococcus aureus strain LA-MRSA ST398 isolate E154
• Function: repression of comK (predicted from homology) Competence regulation

Genomic Context

Location: 1251859..1262632

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AS852_RS06320 (AS852_06055)	trmFO	1252203..1253510 (+)	1308	WP_000195254.1	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	-
AS852_RS06325 (AS852_06060)	xerC	1253927..1254823 (+)	897	WP_001015606.1	tyrosine recombinase XerC	-
AS852_RS06330 (AS852_06065)	hslV	1254820..1255365 (+)	546	WP_000072681.1	ATP-dependent protease subunit HslV	-
AS852_RS06335 (AS852_06070)	hslU	1255431..1256834 (+)	1404	WP_000379054.1	ATP-dependent protease ATPase subunit HslU	-
AS852_RS06340 (AS852_06075)	codY	1256859..1257632 (+)	774	WP_000055337.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
AS852_RS06345 (AS852_06080)	-	1257683..1257775 (+)	93	WP_001790530.1	hypothetical protein	-
AS852_RS06350 (AS852_06085)	rpsB	1257974..1258741 (+)	768	WP_000268484.1	30S ribosomal protein S2	-
AS852_RS06355 (AS852_06090)	-	1258775..1258888 (+)	114	WP_001789890.1	hypothetical protein	-
AS852_RS06360 (AS852_06095)	tsf	1258923..1259804 (+)	882	WP_000201387.1	translation elongation factor Ts	-
AS852_RS06365 (AS852_06100)	pyrH	1259941..1260663 (+)	723	WP_000057330.1	UMP kinase	-
AS852_RS06370 (AS852_06105)	frr	1260682..1261236 (+)	555	WP_001280006.1	ribosome recycling factor	-
AS852_RS06375 (AS852_06110)	-	1261609..1262379 (+)	771	WP_000473705.1	isoprenyl transferase	-

Sequence

Protein

• Length: 257 a.a.
• Molecular weight: 28755.13 Da
• Isoelectric Point: 6.0680

>NTDB_id=139583 AS852_RS06340 WP_000055337.1 1256859..1257632(+) (codY) [Staphylococcus aureus strain LA-MRSA ST398 isolate E154]
MSLLSKTRELNTLLQKHKGIAVDFKDVAQTISSVTVTNVFIVSRRGKILGSSLNELLKSQRIIQMLEERHIPSEYTERLM
EVKQTESNIDIDNVLTVFPPENRELFIDSRTTIFPILGGGERLGTLVLGRVHDDFNENDLVLGEYAATVIGMEILREKHS
EVEKEARDKAAITMAINSLSYSEKEAIEHIFEELGGTEGLLIASKVADRVGITRSVIVNALRKLESAGVIESRSLGMKGT
FIKVKKEKFLDELEKSK

Nucleotide

• Length: 774 bp

>NTDB_id=139583 AS852_RS06340 WP_000055337.1 1256859..1257632(+) (codY) [Staphylococcus aureus strain LA-MRSA ST398 isolate E154]
ATGAGCTTATTATCTAAAACGAGAGAGTTAAACACGTTACTTCAAAAACACAAAGGTATTGCGGTTGATTTTAAAGATGT
AGCACAAACGATTAGTAGCGTAACTGTAACAAATGTATTTATTGTATCGCGTCGAGGTAAAATTTTAGGATCGAGTCTAA
ATGAATTATTAAAAAGTCAAAGAATTATTCAAATGTTGGAAGAAAGACATATTCCAAGTGAATATACAGAACGATTAATG
GAAGTTAAACAAACAGAATCAAATATTGATATCGACAATGTATTAACAGTTTTCCCACCTGAAAACAGAGAATTATTCAT
AGATAGTCGTACAACTATCTTCCCAATTTTAGGTGGAGGAGAAAGATTAGGTACATTAGTACTTGGTCGAGTACATGATG
ATTTTAATGAAAATGATTTGGTACTAGGTGAATATGCTGCTACAGTTATTGGTATGGAAATCTTACGTGAGAAGCATAGT
GAAGTAGAAAAAGAAGCGCGCGATAAAGCTGCTATTACAATGGCAATTAATTCATTATCTTATTCTGAAAAAGAAGCGAT
TGAACATATCTTTGAAGAACTTGGCGGTACGGAAGGCCTATTAATCGCATCAAAAGTTGCAGATAGAGTTGGTATTACTA
GATCTGTAATTGTAAATGCACTACGTAAATTAGAAAGTGCTGGTGTAATTGAATCACGTTCTTTAGGAATGAAAGGTACT
TTTATTAAAGTTAAAAAAGAAAAATTCTTAGATGAATTAGAAAAAAGTAAGTAG

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (2-178)

• CodY helix-turn-helix domain (HTH_CodY) (198-255)

3D structure

• AlphaFold DB: P63843

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Bacillus subtilis subsp. subtilis str. 168	64.202	100	0.642
codY	Lactococcus lactis subsp. lactis strain DGCC12653	42.802	100	0.428