Detailed information NTG0138158

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: SAST41_RS06065
• Genome accession: NZ_CP012978
• Coordinates: 1243244..1245862 (+)
• Length: 872 a.a.
• NCBI ID: WP_000073352.1
• Uniprot ID: P0C1S1
• Organism: Staphylococcus aureus strain ST20130941
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1238244..1250862

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAST41_RS06040 (SAST41_01237)	-	1239126..1239992 (+)	867	WP_000190138.1	2-oxoacid:ferredoxin oxidoreductase subunit beta	-
SAST41_RS06045 (SAST41_01238)	-	1240086..1240379 (+)	294	WP_000655666.1	thiamine-binding protein	-
SAST41_RS06050 (SAST41_01239)	miaB	1240513..1242057 (+)	1545	WP_001001521.1	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	-
SAST41_RS06055 (SAST41_01240)	-	1242058..1242423 (+)	366	WP_000282386.1	RicAFT regulatory complex protein RicA family protein	-
SAST41_RS06060 (SAST41_01241)	thiW	1242450..1242941 (+)	492	WP_000842277.1	energy coupling factor transporter S component ThiW	-
SAST41_RS06065 (SAST41_01242)	hexA	1243244..1245862 (+)	2619	WP_000073352.1	DNA mismatch repair protein MutS	Machinery gene
SAST41_RS06070 (SAST41_01243)	hexB	1245875..1247884 (+)	2010	WP_062909929.1	DNA mismatch repair endonuclease MutL	Machinery gene
SAST41_RS06075 (SAST41_03368)	-	1247890..1248432 (+)	543	WP_001077635.1	glycerol-3-phosphate responsive antiterminator	-
SAST41_RS06080 (SAST41_01245)	-	1248897..1249715 (+)	819	WP_001103743.1	MIP/aquaporin family protein	-

Sequence

Protein

• Length: 872 a.a.
• Molecular weight: 99903.62 Da
• Isoelectric Point: 4.6294

>NTDB_id=138158 SAST41_RS06065 WP_000073352.1 1243244..1245862(+) (hexA) [Staphylococcus aureus strain ST20130941]
MSNVTPMMQQYLKIKSEYQDCLLFFRLGDFYEMFYEDAKEASRVLEITLTKRDAKKENPIPMCGVPYHSADSYIDTLVNN
GYKVAICEQMEDPKQTKGMVRREVVRIVTPGTVMEQGGVDDKQNNYILSFVMNQPEIALSYCDVSTGELKVTHFNDEATL
LNEITTINPNEVVINDNISDNLKRQINMVTETITVRETLSSEIYSVNQTEHKLMYQATQLLLDYIHHTQKRDLSHIEDVV
QYAAIDYMKMDFYAKRNLELTESIRLKSKKGTLLWLMDETKTPMGARRLKQWIDRPLISKEQIEARLDIVDEFSAHFIER
DTLRTYLNQVYDIERLVGRVSYGNVNARDLIQLKHSISEIPNIKALLNSMNQNTLVQVNQLEPLDDLLDILEQSLVEEPP
ISVKDGGLFKVGFNTQLDEYLEASKNGKTWLAELQAKERQRTGIKSLKISFNKVFGYFIEITRANLQNFEPSEFGYMRKQ
TLSNAERFITDELKEKEDIILGAEDKAIELEYQLFVQLREEVKKYTERLQQQAKIISELDCLQSFAEIAQKYNYTRPSFS
ENKTLELVESRHPVVERVMDYNDYVPNNCRLDNETFIYLITGPNMSGKSTYMRQVAIISIMAQMGAYVPCKEAVLPIFDQ
IFTRIGAADDLVSGKSTFMVEMLEAQKALTYATEDSLIIFDEIGRGTSTYDGLALAQAMIEYVAETSHAKTLFSTHYHEL
TTLDQALPSLKNVHVAANEYKGELIFLHKVKDGAVDDSYGIQVAKLADLPEKVISRAQVILSEFEASAGKKSSISNLKMV
ENEPEINQENLNLSVEETTDTLSQKDFEQASFDLFENDQESEIELQIKNLNLSNMTPIEALVKLSELQNQLK

Nucleotide

• Length: 2619 bp

>NTDB_id=138158 SAST41_RS06065 WP_000073352.1 1243244..1245862(+) (hexA) [Staphylococcus aureus strain ST20130941]
ATGTCTAATGTTACACCAATGATGCAGCAATATTTAAAAATAAAATCAGAATACCAAGATTGCTTATTATTTTTTAGACT
AGGTGATTTCTATGAAATGTTTTATGAAGATGCCAAGGAGGCATCACGTGTACTTGAAATTACTTTGACTAAAAGAGATG
CTAAAAAAGAAAATCCAATTCCGATGTGTGGTGTTCCGTATCATTCTGCAGATAGTTATATAGATACACTTGTTAATAAT
GGATATAAAGTAGCTATTTGTGAACAGATGGAAGATCCGAAACAAACGAAAGGTATGGTTAGACGTGAGGTAGTAAGAAT
TGTGACTCCAGGAACTGTGATGGAGCAAGGTGGTGTAGATGATAAACAAAATAACTATATTTTAAGTTTTGTTATGAATC
AACCTGAAATTGCGCTTAGTTACTGTGATGTTTCTACTGGCGAATTAAAGGTTACACATTTTAATGATGAAGCGACTTTA
TTAAATGAAATTACGACGATAAACCCTAACGAAGTTGTTATCAATGACAATATTTCCGATAATTTAAAAAGACAAATTAA
TATGGTGACAGAAACAATAACAGTCAGGGAAACGTTATCATCAGAAATCTATAGTGTGAATCAAACTGAACATAAATTAA
TGTATCAAGCGACACAATTATTGCTAGATTATATTCATCATACACAAAAACGTGATTTATCGCATATCGAGGATGTTGTT
CAATATGCAGCTATAGATTATATGAAAATGGATTTTTATGCTAAGAGAAACCTTGAGTTAACGGAAAGCATTCGATTAAA
ATCAAAAAAAGGAACGCTACTTTGGCTAATGGACGAAACGAAAACACCAATGGGAGCACGCCGCTTAAAACAATGGATAG
ATAGACCACTAATAAGTAAAGAACAAATTGAAGCACGATTAGATATCGTTGATGAATTTAGTGCTCATTTCATAGAAAGA
GACACCTTAAGAACATATCTTAATCAAGTGTATGATATTGAACGTCTTGTTGGGCGTGTTAGTTACGGAAATGTTAATGC
GAGAGATTTAATTCAACTTAAACATTCCATTTCTGAAATACCGAATATTAAAGCATTACTAAATTCTATGAATCAGAATA
CGCTTGTACAAGTTAATCAACTAGAACCCCTTGATGATTTACTTGATATATTAGAACAGAGTTTAGTAGAAGAACCACCA
ATTTCAGTTAAAGATGGCGGACTATTCAAAGTTGGTTTTAATACGCAATTAGATGAATATCTTGAAGCTTCAAAAAACGG
AAAAACATGGTTAGCAGAATTACAAGCCAAAGAAAGACAACGTACAGGAATAAAATCATTGAAAATAAGCTTTAATAAAG
TGTTTGGTTATTTTATAGAAATAACACGTGCCAACTTGCAAAATTTTGAACCAAGTGAATTTGGTTATATGAGGAAGCAA
ACGTTATCGAATGCTGAACGTTTTATAACTGATGAACTTAAAGAAAAAGAAGATATCATTTTAGGTGCGGAAGACAAAGC
CATCGAATTAGAATATCAATTATTTGTTCAGCTACGTGAAGAAGTTAAAAAATATACTGAACGTTTACAACAACAAGCTA
AAATTATTTCAGAGCTAGATTGTTTACAGAGCTTTGCAGAAATTGCTCAAAAATATAATTACACTAGGCCTTCATTTAGT
GAAAATAAAACATTAGAATTAGTGGAATCTAGGCACCCAGTAGTGGAAAGAGTAATGGATTATAATGACTATGTGCCTAA
TAATTGTCGATTAGATAATGAAACATTTATATATTTAATTACAGGTCCGAATATGTCTGGTAAATCGACATATATGAGAC
AAGTTGCCATAATTAGTATAATGGCCCAAATGGGAGCTTATGTCCCTTGTAAAGAGGCAGTGTTACCTATATTTGATCAA
ATATTCACTAGAATAGGTGCGGCAGATGATTTGGTTTCAGGTAAGAGTACGTTTATGGTAGAAATGCTAGAAGCACAAAA
GGCATTAACTTATGCAACAGAGGATAGTTTGATTATTTTCGATGAAATTGGACGTGGTACTTCAACGTATGACGGTTTAG
CTTTAGCGCAGGCAATGATAGAGTATGTAGCTGAAACATCACATGCTAAAACGTTATTTTCAACACATTATCATGAATTG
ACAACATTAGATCAAGCATTACCAAGTCTAAAAAATGTTCACGTCGCTGCTAATGAATATAAAGGTGAACTTATATTCTT
GCATAAAGTCAAAGATGGTGCAGTTGACGATAGTTATGGTATTCAAGTTGCGAAATTAGCTGATTTACCTGAAAAAGTTA
TTAGCAGAGCACAAGTGATCCTAAGCGAGTTTGAAGCGTCTGCTGGTAAAAAATCATCGATATCAAATTTAAAAATGGTC
GAAAATGAACCTGAAATTAATCAAGAAAATTTAAACTTAAGTGTTGAAGAAACAACTGATACTTTATCTCAAAAAGACTT
TGAACAAGCATCATTTGATTTGTTTGAAAATGATCAAGAAAGCGAGATTGAACTACAAATTAAAAATTTGAATTTATCTA
ATATGACACCAATTGAGGCATTGGTGAAGTTAAGTGAATTACAAAATCAATTAAAATAG

Domains

Predicted by InterProScan.

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (412-505)

• MutS domain I (MutS_I) (5-115)

• MutS domain V (MutS_V) (599-785)

• MutS domain II (MutS_II) (125-237)

3D structure

• AlphaFold DB: P0C1S1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	45.455	100	0.459