Detailed information    

experimental Experimentally validated

Overview

Name   comO   Type   Machinery gene
Locus tag   HI_0939 Genome accession   L42023
Coordinates   997770..998486 (+) Length   238 a.a.
NCBI ID   AAC22603.1    Uniprot ID   -
Organism   Haemophilus influenzae Rd KW20     
Function   type IV pilus biogenesis and function   
DNA binding and uptake

Function

All genes in the comABCDE, comNOPQ, and pilABCD operons play essential roles in competence.


Genomic Context

Location: 992770..1003486
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HI_0935 - 993708..994238 (-) 531 AAC22593.1 thiol:disulfide interchange protein (dsbE) -
  HI_0936 - 994238..996145 (-) 1908 AAC22594.1 cytochrome C-type biogenesis -
  HI_0937 - 996254..997057 (-) 804 AAC22595.1 extragenic suppressor (suhB) -
  HI_0938 comN 997258..997770 (+) 513 AAC22602.1 predicted coding region HI0938 Machinery gene
  HI_0939 comO 997770..998486 (+) 717 AAC22603.1 predicted coding region HI0939 Machinery gene
  HI_0940 comP 998486..999169 (+) 684 AAC22604.1 predicted coding region HI0940 Machinery gene
  HI_0941 comQ 999144..999449 (+) 306 AAC22605.1 predicted coding region HI0941 Machinery gene
  HI_0942 - 999495..1002860 (+) 3366 AAC22596.1 exodeoxyribonuclease V, gamma chain (recC) -
  HI_0943 - 1002915..1003364 (+) 450 AAC22597.1 conserved hypothetical protein -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 26787.17 Da        Isoelectric Point: 9.5508

>NTDB_id=1351 HI_0939 AAC22603.1 997770..998486(+) (comO) [Haemophilus influenzae Rd KW20]
MMKVLLKGQTLLALMISLSLSSLLLLSISHFYVQIQTQNQHMLLHLKLQAELQRTLQLIGKDLRRLGFRALNAKLTESNL
SLFELDEQGTAIFISQEDNAPPNSCVLFFYDLNKNGCIGKGSPKTCMKKGKNTSKSSTEELFGYKVSNKMIKTKLTYQSV
IPTNCTAETCKRAFQQTACNAGGGWADLLDNNEYEITRLQFNWLIEGKGLEIKLKGNLKQTPNISYETSLVVVLWNQK

Nucleotide


Download         Length: 717 bp        

>NTDB_id=1351 HI_0939 AAC22603.1 997770..998486(+) (comO) [Haemophilus influenzae Rd KW20]
ATGATGAAAGTATTATTAAAAGGGCAAACCCTATTAGCACTGATGATTTCACTGTCTTTGTCGTCTTTATTATTGCTAAG
CATTTCGCATTTTTATGTGCAAATACAAACGCAAAATCAACACATGTTATTACATTTAAAATTACAAGCTGAATTACAAC
GAACATTACAGTTAATAGGTAAAGATCTTCGCCGATTAGGATTTCGAGCATTAAATGCAAAACTGACGGAAAGCAATTTA
TCTTTATTTGAATTAGATGAACAAGGCACAGCTATTTTTATTAGCCAAGAAGATAATGCGCCACCTAATAGCTGCGTGTT
GTTCTTTTATGATTTAAATAAAAATGGGTGTATTGGCAAAGGTTCGCCGAAAACCTGTATGAAAAAAGGTAAAAATACAT
CTAAAAGTAGTACTGAAGAATTATTCGGCTATAAAGTGAGTAACAAAATGATAAAAACTAAACTGACTTATCAAAGTGTT
ATTCCTACTAATTGCACGGCAGAAACTTGTAAACGTGCTTTTCAACAAACCGCTTGTAACGCTGGTGGTGGATGGGCAGA
TTTATTAGATAACAACGAATATGAAATCACTAGGTTACAATTTAATTGGTTAATTGAAGGCAAAGGATTAGAAATCAAGC
TAAAAGGAAATTTAAAACAAACCCCAAATATCAGTTATGAAACATCCCTTGTTGTTGTGCTCTGGAATCAAAAATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value

References

[1] Sunita Sinha et al. (2012) Seventeen Sxy-dependent cyclic AMP receptor protein site-regulated genes are needed for natural transformation in Haemophilus influenzae. Journal of Bacteriology 194(19):5245-54. [PMID: 22821979]
[2] Timothy M VanWagoner et al. (2004) Characterization of three new competence-regulated operons in Haemophilus influenzae. Journal of Bacteriology 186(19):6409-21. [PMID: 15375121]