Detailed information NTG0133366

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: DE8669_RS06960
• Genome accession: NZ_CP012391
• Coordinates: 1360072..1362651 (-)
• Length: 859 a.a.
• NCBI ID: WP_002223597.1
• Uniprot ID: -
• Organism: Neisseria meningitidis strain DE8669
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 1355072..1367651

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DE8669_RS06940 (DE8669_1301)	-	1356001..1357266 (+)	1266	WP_014581011.1	Glu/Leu/Phe/Val family dehydrogenase	-
DE8669_RS06945 (DE8669_1302)	-	1357323..1358129 (-)	807	WP_065826054.1	DUF4198 domain-containing protein	-
DE8669_RS06950 (DE8669_1303)	-	1358473..1358682 (+)	210	WP_002212949.1	tautomerase family protein	-
DE8669_RS06955 (DE8669_1304)	-	1358771..1359985 (+)	1215	WP_002223596.1	pyridoxal phosphate-dependent aminotransferase	-
DE8669_RS06960 (DE8669_1305)	clpC	1360072..1362651 (-)	2580	WP_002223597.1	ATP-dependent chaperone ClpB	Regulator
DE8669_RS06965 (DE8669_1306)	trpS	1362912..1363922 (+)	1011	WP_002226234.1	tryptophan--tRNA ligase	-
DE8669_RS06970 (DE8669_1307)	-	1363928..1364269 (+)	342	WP_002247016.1	hypothetical protein	-
DE8669_RS06975 (DE8669_1308)	-	1364591..1364914 (+)	324	WP_002225099.1	Ag473 family lipoprotein	-
DE8669_RS06980 (DE8669_1309)	ppx	1365123..1366631 (-)	1509	WP_002252094.1	exopolyphosphatase	-
DE8669_RS06990 (DE8669_1310)	-	1366747..1367479 (-)	733	Protein_1317	surface lipoprotein assembly modifier	-

Sequence

Protein

• Length: 859 a.a.
• Molecular weight: 95200.56 Da
• Isoelectric Point: 5.2553

>NTDB_id=133366 DE8669_RS06960 WP_002223597.1 1360072..1362651(-) (clpC) [Neisseria meningitidis strain DE8669]
MRYDKLTAKFQQALAEAQSLALAADGSYLEAGFVLKALLDDQNSGAAALLAHAGVNVPQVKQRLQQHLNSLPKVSGQGGD
IMPSRELQAVLNLMDKAATKRGDAYIASELFLLALVQQNDATGKILKEAGATEQNINAAIDAVRGGQNVNDANAEDQRDA
LKKYTLDLTQRARDGKLDPVIGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPESLRNKRLLVL
DLAALIAGAKYRGEFEERLKGVLNDLAKDDGNTLIFIDEIHTLVGAGKTDGAMDAGNMLKPALARGELHCIGATTLDEYR
QYIEKDAALERRFQKVLVGEPSVEDTIAILRGLQERYEIHHGIDITDPAIVAAAELSDRYITDRFLPDKAIDLIDEAASR
VKMEKETKPEAMDKIDRRLIQLRMEKAHVEKEKDDASKKRLELIDEEINGLQKEYADLDEIWKAEKAISDGAANIKKQID
EVKIKIEQAKRQGDLALASKLMYEDLEHLEKQRAAAERADTDSTKPANKLLRNNVGAEEIAEVVSRMTGIPVSKMMEGER
DKLLKMEEVLHRRVVGQDEAVRAVSDAIRRSRSGLADPNKPYGSFLFLGPTGVGKTELCKALAGFLFDSEDHLIRIDMSE
YMEKHAVARLIGAPPGYVGYEEGGYLTEQVRRKPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFKNTVIVM
TSNIGSQHIQQMGTQDYEAVKEVVMEDVKEHFRPEMINRIDEVVVFHGLDQDNIRNIAKIQLKGLEKRLEKQNLRLTVSD
AALDIIAKAGFDPIYGARPLKRAIQSEIENPLAKALLAGNYAPESEIRVEADGDRLKFA

Nucleotide

• Length: 2580 bp

>NTDB_id=133366 DE8669_RS06960 WP_002223597.1 1360072..1362651(-) (clpC) [Neisseria meningitidis strain DE8669]
ATGCGATACGACAAATTAACCGCCAAATTCCAACAGGCCCTTGCAGAAGCTCAGAGTTTGGCGTTGGCTGCGGACGGCAG
CTATCTGGAAGCGGGCTTTGTGCTGAAAGCCCTGCTTGACGACCAAAACAGCGGTGCTGCCGCGCTCTTGGCTCATGCGG
GCGTGAACGTGCCGCAGGTGAAACAGCGTTTGCAGCAGCATTTGAACAGCCTGCCGAAAGTATCCGGACAGGGCGGCGAC
ATTATGCCCAGCCGCGAATTGCAGGCGGTGTTGAACCTGATGGACAAAGCAGCAACCAAACGCGGCGATGCCTATATCGC
CAGCGAACTTTTCCTGCTCGCCTTGGTGCAGCAGAACGATGCAACCGGCAAAATTTTGAAAGAAGCCGGCGCGACCGAAC
AAAACATTAATGCCGCAATCGATGCGGTACGAGGAGGACAAAACGTGAACGATGCCAATGCCGAAGACCAACGCGATGCG
CTGAAAAAATATACGCTCGATTTGACCCAACGCGCCCGCGACGGTAAGCTCGACCCCGTTATCGGTCGTGACGACGAAAT
CCGCCGTGCAATTCAGGTATTGCAACGCCGCACCAAAAACAACCCCGTGCTGATTGGCGAACCGGGCGTGGGTAAAACTG
CCATTGTCGAAGGCTTGGCGCAACGCATCGTCAACGGCGAAGTACCCGAATCCCTGCGCAACAAACGCCTTTTGGTTCTG
GACTTGGCGGCATTGATTGCCGGCGCGAAATACCGTGGCGAATTTGAAGAACGCTTGAAAGGCGTGTTGAACGATTTGGC
GAAAGACGACGGCAACACTCTGATTTTCATTGATGAAATCCATACTTTGGTCGGCGCGGGCAAAACCGACGGCGCGATGG
ACGCGGGCAATATGCTGAAACCGGCCTTGGCGCGGGGCGAACTGCACTGTATCGGCGCGACCACCTTGGACGAATACCGC
CAATACATCGAAAAAGACGCGGCACTCGAACGCCGCTTCCAAAAAGTATTGGTCGGCGAGCCCAGCGTGGAAGACACCAT
CGCCATCTTGCGCGGTTTGCAGGAGCGTTATGAAATCCACCACGGTATCGATATTACCGACCCTGCTATCGTTGCCGCAG
CGGAGTTGAGCGACCGCTACATCACCGACCGCTTCCTGCCCGACAAAGCGATTGATTTGATTGATGAAGCCGCCAGCCGT
GTCAAGATGGAAAAAGAAACCAAGCCGGAAGCAATGGACAAAATCGACCGCCGTCTGATTCAGCTTCGGATGGAAAAGGC
ACACGTTGAAAAAGAAAAAGACGATGCCAGCAAAAAACGTTTGGAACTGATAGACGAGGAAATCAACGGTCTGCAAAAAG
AATACGCCGATTTAGACGAAATCTGGAAAGCCGAAAAAGCAATTTCAGACGGTGCTGCTAATATTAAGAAACAAATTGAC
GAAGTCAAAATTAAAATCGAACAGGCAAAACGGCAAGGCGATTTGGCACTGGCTTCAAAATTGATGTATGAAGATTTGGA
GCATTTGGAAAAACAGCGTGCAGCCGCCGAACGGGCAGATACGGACAGCACAAAACCGGCAAACAAACTCTTGCGTAATA
ATGTCGGCGCGGAGGAAATCGCAGAAGTTGTTTCCCGTATGACCGGTATTCCCGTGTCCAAAATGATGGAAGGCGAACGC
GACAAACTGCTGAAGATGGAAGAAGTATTGCACCGCCGCGTGGTCGGTCAAGATGAAGCCGTGCGTGCCGTGTCCGACGC
TATCCGCCGCAGCCGTTCCGGTCTTGCCGATCCGAACAAACCTTACGGCAGCTTCCTGTTCTTAGGCCCGACCGGCGTGG
GTAAGACCGAATTGTGTAAGGCATTGGCAGGCTTCCTGTTTGACAGTGAAGATCATCTGATTCGTATCGATATGTCCGAA
TATATGGAAAAACACGCCGTTGCCCGCTTAATCGGCGCGCCTCCGGGCTATGTCGGCTACGAAGAAGGCGGCTACCTGAC
TGAGCAAGTCCGCCGCAAACCGTACAGCGTGATTCTTTTGGACGAAGTGGAAAAAGCCCATCCCGACGTGTTCAATATCC
TGCTGCAAGTTTTGGATGACGGTCGTTTGACCGACGGACAAGGCAGGACGGTAGATTTTAAAAACACCGTGATTGTGATG
ACTTCCAACATTGGCAGCCAGCACATCCAACAAATGGGCACGCAGGACTACGAAGCCGTGAAAGAAGTTGTGATGGAGGA
TGTGAAAGAGCATTTCCGTCCTGAAATGATCAACCGCATCGACGAAGTGGTCGTGTTCCACGGACTGGATCAGGATAATA
TCCGCAACATTGCGAAAATCCAGCTCAAAGGCTTGGAAAAACGTTTGGAAAAACAAAACCTCCGCCTGACTGTTTCCGAT
GCCGCTCTGGACATCATCGCCAAAGCCGGTTTCGACCCGATTTACGGCGCACGTCCGCTCAAACGCGCCATCCAGTCGGA
AATCGAAAACCCGCTGGCAAAAGCCCTGCTTGCCGGAAACTATGCGCCCGAAAGCGAAATCAGGGTAGAAGCCGACGGCG
ACAGACTGAAATTTGCCTGA

Domains

Predicted by InterProScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (203-336)

• AAA lid domain (AAA_lid_9) (342-442)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (769-849)

• AAA domain (Cdc48 subfamily) (AAA_2) (601-763)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (96-145)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	43.902	100	0.44
clpC	Streptococcus pneumoniae Rx1	38.981	100	0.41
clpC	Streptococcus pneumoniae TIGR4	38.981	100	0.41
clpC	Streptococcus pneumoniae D39	38.981	100	0.41
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	38.274	100	0.403
clpC	Lactococcus lactis subsp. cremoris KW2	46.983	81.024	0.381
clpE	Streptococcus pneumoniae TIGR4	47.214	79.395	0.375
clpE	Streptococcus mutans UA159	45.19	79.86	0.361