Detailed information NTG0130707

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: HKU360_RS00325
• Genome accession: NZ_CP009612
• Coordinates: 53049..53960 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain HKU360
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48049..58960

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HKU360_RS00305 (HKU360_00062)	purE	48343..48834 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HKU360_RS00310 (HKU360_00063)	purK	48821..49894 (+)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HKU360_RS00315 (HKU360_00064)	-	49915..51255 (+)	1341	WP_002987721.1	hypothetical protein	-
HKU360_RS00320 (HKU360_00065)	purB	51624..52916 (+)	1293	WP_002987723.1	adenylosuccinate lyase	-
HKU360_RS00325 (HKU360_00066)	comR	53049..53960 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
HKU360_RS10605 (HKU360_00067)	comS	54044..54139 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
HKU360_RS00330 (HKU360_00068)	ruvB	54186..55184 (+)	999	WP_002987726.1	Holliday junction branch migration DNA helicase RuvB	-
HKU360_RS00335 (HKU360_00069)	-	55322..55759 (+)	438	WP_002987727.1	low molecular weight protein-tyrosine-phosphatase	-
HKU360_RS00340 (HKU360_00070)	-	55783..56184 (+)	402	WP_002987730.1	MORN repeat-containing protein	-
HKU360_RS00345 (HKU360_00071)	-	56181..57956 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=130707 HKU360_RS00325 WP_002986681.1 53049..53960(+) (comR) [Streptococcus pyogenes strain HKU360]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=130707 HKU360_RS00325 WP_002986681.1 53049..53960(+) (comR) [Streptococcus pyogenes strain HKU360]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462