Detailed information NTG0127449

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: SAH002_RS03735
• Genome accession: NZ_CP011329
• Coordinates: 692106..692891 (+)
• Length: 261 a.a.
• NCBI ID: WP_000825431.1
• Uniprot ID: Q8E0P2
• Organism: Streptococcus agalactiae strain H002
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 687106..697891

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAH002_RS11455 (SAH002_03710)	-	688223..688666 (+)	444	WP_001048166.1	hypothetical protein	-
SAH002_RS11460 (SAH002_03715)	-	688751..689017 (+)	267	WP_001865676.1	hypothetical protein	-
SAH002_RS11465 (SAH002_03720)	-	689118..689246 (+)	129	WP_000962057.1	hypothetical protein	-
SAH002_RS11470 (SAH002_03725)	-	689255..689575 (+)	321	WP_001865677.1	hypothetical protein	-
SAH002_RS03725 (SAH002_03730)	-	689672..690343 (+)	672	WP_000891268.1	ATP-binding cassette domain-containing protein	-
SAH002_RS03730 (SAH002_03735)	-	690400..691845 (-)	1446	WP_000750933.1	FAD/NAD(P)-binding protein	-
SAH002_RS03735 (SAH002_03740)	endA	692106..692891 (+)	786	WP_000825431.1	DNA/RNA non-specific endonuclease	Machinery gene
SAH002_RS03740 (SAH002_03745)	-	692969..693607 (-)	639	WP_000478529.1	VTT domain-containing protein	-
SAH002_RS03745 (SAH002_03750)	-	693824..694480 (+)	657	WP_000121094.1	ATP-binding cassette domain-containing protein	-
SAH002_RS03750 (SAH002_03755)	-	694477..695250 (+)	774	WP_000012390.1	ABC transporter permease	-
SAH002_RS03755 (SAH002_03760)	-	695414..696232 (+)	819	WP_000601007.1	hypothetical protein	-
SAH002_RS03760 (SAH002_03765)	-	696269..697153 (-)	885	WP_000354840.1	LysR family transcriptional regulator	-
SAH002_RS03765 (SAH002_03770)	-	697346..697852 (+)	507	Protein_675	PTS sugar transporter subunit IIC	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 29424.86 Da
• Isoelectric Point: 8.9989

>NTDB_id=127449 SAH002_RS03735 WP_000825431.1 692106..692891(+) (endA) [Streptococcus agalactiae strain H002]
MKRLHKLFITVIATLGMLGVMTFGLPTQPQNVTPIVHADVNSSVDTSQEFQNNLKNAIGNLPFQYVNGIYELNNNQTNLN
ADVNVKAYVQNTIDNQQRLSTANAMLDRTIRQYQNRRDTTLPDANWKPLGWHQVATNDHYGHAVDKGHLIAYALAGNFKG
WDASVSNPQNVVTQTAHSNQSNQKINRGQNYYESLVRKAVDQNKRVRYRVTPLYRNDTDLVPFAMHLEAKSQDGTLEFNV
AIPNTQASYTMDYATGEITLN

Nucleotide

• Length: 786 bp

>NTDB_id=127449 SAH002_RS03735 WP_000825431.1 692106..692891(+) (endA) [Streptococcus agalactiae strain H002]
ATGAAAAGATTACATAAACTGTTTATAACCGTAATTGCTACATTAGGTATGTTGGGGGTAATGACCTTTGGTCTTCCAAC
GCAGCCGCAAAACGTAACGCCGATAGTACATGCTGATGTCAATTCATCTGTTGATACGAGCCAGGAATTTCAAAATAATT
TAAAAAATGCTATTGGTAACCTACCATTTCAATATGTTAATGGTATTTATGAATTAAATAATAATCAGACAAATTTAAAT
GCTGATGTCAATGTTAAAGCGTATGTTCAAAATACAATTGACAATCAACAAAGACTATCAACTGCTAATGCAATGCTTGA
TAGAACCATTCGTCAATATCAAAATCGCAGAGATACCACTCTTCCCGATGCAAATTGGAAACCATTAGGTTGGCATCAAG
TAGCTACTAATGACCATTATGGACATGCAGTCGACAAGGGGCATTTAATTGCCTATGCTTTAGCTGGAAATTTCAAAGGT
TGGGATGCTTCCGTGTCAAATCCTCAAAATGTTGTCACACAAACAGCTCATTCCAACCAATCAAATCAAAAAATCAATCG
TGGACAAAATTATTATGAAAGCTTAGTTCGTAAGGCGGTTGACCAAAACAAACGTGTTCGTTACCGTGTAACTCCATTGT
ACCGTAATGATACTGATTTAGTTCCATTTGCAATGCACCTAGAAGCTAAATCACAAGATGGCACATTAGAATTTAATGTT
GCTATTCCAAACACACAAGCATCATACACTATGGATTATGCAACAGGAGAAATAACACTAAATTAA

Domains

Predicted by InterProScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (77-235)

3D structure

• AlphaFold DB: Q8E0P2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	51.515	75.862	0.391
endA	Streptococcus pneumoniae D39	51.515	75.862	0.391
endA	Streptococcus pneumoniae R6	51.515	75.862	0.391
endA	Streptococcus pneumoniae TIGR4	51.515	75.862	0.391