Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB4   Type   Machinery gene
Locus tag   CS888_RS00120 Genome accession   NZ_LT635473
Coordinates   16699..19065 (+) Length   788 a.a.
NCBI ID   WP_089086466.1    Uniprot ID   A0A238GTG4
Organism   Helicobacter pylori isolate HE136/09     
Function   transformation-associated type IV transport system (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 11699..24065
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CS888_RS00085 groES 11717..12073 (-) 357 WP_000671927.1 co-chaperone GroES -
  CS888_RS00095 dnaG 12360..14039 (+) 1680 WP_089086464.1 DNA primase -
  CS888_RS00100 - 14036..15088 (+) 1053 WP_089086465.1 MnmA/TRMU family protein -
  CS888_RS00105 - 15181..16008 (+) 828 WP_001154942.1 DUF5718 family protein -
  CS888_RS00110 comB2 16153..16434 (+) 282 WP_001272686.1 TrbC/VirB2 family protein Machinery gene
  CS888_RS00115 comB3 16434..16697 (+) 264 WP_000584948.1 hypothetical protein Machinery gene
  CS888_RS00120 comB4 16699..19065 (+) 2367 WP_089086466.1 VirB4 family type IV secretion/conjugal transfer ATPase Machinery gene
  CS888_RS00130 - 19370..20710 (+) 1341 WP_001876830.1 COG3014 family protein -
  CS888_RS00135 cheV1 20817..21782 (+) 966 WP_000785482.1 chemotaxis protein CheV1 -
  CS888_RS00140 nspC 21779..22996 (+) 1218 WP_000760798.1 carboxynorspermidine decarboxylase -
  CS888_RS00145 lpxE 23083..23616 (-) 534 WP_231628461.1 lipid A 1-phosphatase LpxE -

Sequence

Protein


Download         Length: 788 a.a.        Molecular weight: 90214.54 Da        Isoelectric Point: 7.9708

>NTDB_id=1145781 CS888_RS00120 WP_089086466.1 16699..19065(+) (comB4) [Helicobacter pylori isolate HE136/09]
MLEKFLGAIKQKVSNYFLGALPKSYSMSEENNILGLYDEHFLLTKNENLVGILRLEGVSYTHLSTEQLQDLFTERQMALD
SLEKVVARLVVKRRKIDYQQNIQSDSQYLQAILNQFENKEVYENQYFLVLESTHSLHGVLEHKKKSFMHANRENFKDILS
YKAHFLQETLKSLEIQLKNYAPKLLSSKEVLNFYAEYINGFDLPLKPPLVGGYLSDSYIASSITFEKDYFIQESFNQKTY
NRLIGVKAYESERITSIAVGALLYQETPLDIIFSIEPMSAHKTLSFLKERAKFSMSNLVKNELLEYQELVKTKRLSMQKF
ALNVLIKAPSLEDLDAQTSLVLGLLFKENLVGVIETFGLKGGYFSFFPERIYLNHRLRFLTSKALACLMVFERQNLGFKA
NSWGNSPLSVFKNLDYSPFLFNFHNQEVSHNNAKEIARVNGHTLVIGATGSGKSTLISFLMMSALKYQNMRLLAFDRMQG
LYSFTEFFKGHYHDGQSFSINPFCLEPNLQNLEFLQSFFLSMFDLAPSRDKEALEDMNAISGAIKSLYETLYPKAFSLLD
FKETLKRTSSNQLGLSLEPYLNNPLFNALNDAFNSSAFLNVINLDAITQNPKDLGLLAYYLFYKILEESRKNDSGFLVFL
DEFKSYVENDLLNTKINALITQARKANGVVVLALQDIYQLSGVKNAHSFLSNMGTLILYPQKNARELKHNFNVPLSETEI
SFLENTPLYARQVLVKNLGNGSSNMIDVSLEGLGRYLKIFNSDSSHVNKVKALQKDYPTEWREKLLKS

Nucleotide


Download         Length: 2367 bp        

>NTDB_id=1145781 CS888_RS00120 WP_089086466.1 16699..19065(+) (comB4) [Helicobacter pylori isolate HE136/09]
ATGTTAGAAAAGTTTTTAGGCGCTATCAAGCAAAAAGTTTCAAATTATTTTTTAGGGGCTTTGCCTAAAAGCTATTCAAT
GAGTGAAGAAAACAACATTTTAGGCTTGTATGATGAGCATTTTTTACTCACTAAAAACGAAAACTTAGTGGGCATTCTCC
GTTTAGAGGGGGTGAGTTACACCCATTTAAGCACAGAGCAATTGCAAGATCTTTTCACCGAGCGTCAGATGGCGTTGGAT
TCTTTAGAAAAAGTCGTGGCGCGCTTGGTGGTTAAAAGGCGTAAAATTGATTATCAACAAAACATTCAATCTGACTCTCA
ATACTTGCAAGCGATCTTGAATCAGTTTGAAAATAAAGAAGTGTATGAGAATCAGTATTTTTTGGTTTTAGAAAGCACTC
ACTCTTTGCATGGGGTTTTAGAGCATAAGAAAAAATCTTTCATGCACGCTAATAGGGAAAATTTTAAGGATATTCTCTCT
TATAAAGCGCATTTTTTGCAAGAAACTTTAAAAAGCCTAGAAATCCAGCTCAAAAACTATGCCCCCAAACTCTTAAGCTC
TAAAGAGGTTTTGAATTTTTATGCAGAATATATTAATGGGTTTGATCTCCCCTTAAAGCCCCCCCTAGTAGGGGGGTATT
TGAGCGATAGCTATATCGCTAGTTCTATCACTTTTGAAAAAGATTATTTCATTCAAGAAAGCTTTAACCAAAAAACCTAC
AACCGCTTGATTGGCGTTAAGGCTTATGAGAGCGAAAGGATCACTTCTATAGCGGTGGGAGCGCTTTTATACCAAGAAAC
GCCTTTAGATATTATCTTTTCCATAGAGCCTATGAGCGCGCATAAAACGCTGAGTTTTTTAAAAGAGAGAGCCAAGTTTA
GCATGTCCAATCTCGTTAAAAACGAGCTGCTAGAATACCAGGAATTAGTCAAAACCAAACGCTTATCCATGCAAAAATTC
GCCCTAAATGTTCTTATCAAAGCCCCCAGTTTAGAGGATTTAGACGCTCAAACGAGCTTAGTTTTAGGGCTTTTATTTAA
AGAAAACTTAGTGGGCGTTATAGAAACTTTTGGCTTGAAAGGGGGGTATTTTTCCTTTTTCCCTGAACGCATTTATTTAA
ACCACCGCTTGCGTTTTTTGACCTCTAAAGCCCTAGCGTGTTTGATGGTGTTTGAAAGGCAAAATTTAGGTTTTAAGGCT
AATTCATGGGGGAATAGCCCTTTGAGCGTGTTTAAAAATTTGGATTATTCCCCTTTTTTATTCAATTTCCACAACCAAGA
AGTGAGCCATAATAACGCTAAAGAAATCGCCAGAGTGAATGGGCATACTTTAGTTATAGGGGCAACCGGAAGCGGTAAAA
GCACGCTGATTAGCTTTTTAATGATGAGCGCTTTGAAATACCAGAACATGCGCCTTTTAGCTTTTGATAGGATGCAAGGG
CTGTATTCTTTCACCGAATTTTTTAAAGGGCATTACCATGACGGCCAATCTTTTAGTATCAACCCCTTTTGTTTAGAGCC
TAATTTACAGAATTTAGAATTTTTGCAATCCTTCTTTTTGAGCATGTTTGATCTCGCCCCTTCAAGGGATAAAGAAGCCT
TAGAAGACATGAATGCGATTTCTGGCGCGATTAAGAGCCTTTATGAGACCTTATACCCTAAAGCCTTTAGTTTGCTAGAC
TTTAAAGAAACGCTTAAAAGAACCTCATCTAACCAATTGGGCTTGAGCTTGGAGCCGTATTTGAATAACCCCCTTTTTAA
CGCTTTGAATGATGCGTTCAACTCCAGTGCTTTTTTAAATGTGATAAACCTAGATGCTATCACTCAAAACCCTAAAGATT
TAGGGCTTTTAGCCTATTATTTGTTTTATAAGATCTTAGAAGAGTCCAGGAAAAACGACAGCGGCTTTTTGGTTTTTTTA
GACGAATTTAAATCCTATGTGGAAAACGATTTGTTGAACACTAAAATCAACGCTTTAATCACGCAAGCCAGGAAAGCTAA
TGGCGTGGTGGTGTTGGCTTTGCAAGATATTTACCAATTAAGTGGAGTCAAAAACGCCCATAGTTTTTTAAGCAACATGG
GGACTCTCATTTTGTATCCGCAAAAAAACGCTAGGGAATTGAAACACAACTTCAATGTGCCTTTGAGCGAGACTGAAATT
TCATTTTTAGAAAACACCCCTTTGTATGCCAGGCAGGTTTTAGTCAAAAATCTGGGTAACGGGAGTTCTAACATGATTGA
TGTGAGTTTGGAGGGCTTGGGGCGTTATTTGAAGATCTTTAATTCAGATTCTAGTCATGTGAATAAAGTGAAAGCGTTAC
AAAAAGACTACCCTACAGAGTGGCGTGAGAAACTTTTGAAGAGTTAG

Domains

Predicted by InterproScan.

CagE, TrbE, VirB family, component of type IV transporter system (CagE_TrbE_VirB)

(176-376)

FtsK/SpoIIIE family (FtsK_SpoIIIE)

(427-467)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A238GTG4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB4 Helicobacter pylori 26695

97.335

100

0.973

Multiple sequence alignment