Detailed information NTG1142084

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: DQL01_RS10120
• Genome accession: NZ_LS483451
• Coordinates: 1889835..1890659 (-)
• Length: 274 a.a.
• NCBI ID: WP_001036791.1
• Uniprot ID: A0A0B7L7Z9
• Organism: Streptococcus pneumoniae strain 4041STDY6836166
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1891016..1892269	1889835..1890659	flank	357

Gene organization within MGE regions

Location: 1889835..1892269

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL01_RS10120	endA	1889835..1890659 (-)	825	WP_001036791.1	DNA-entry nuclease EndA	Machinery gene
DQL01_RS10125	-	1891016..1892269 (+)	1254	WP_061368780.1	IS110-like element ISSpn10 family transposase	-

Sequence

Protein

• Length: 274 a.a.
• Molecular weight: 29939.65 Da
• Isoelectric Point: 10.1700

>NTDB_id=1142084 DQL01_RS10120 WP_001036791.1 1889835..1890659(-) (endA) [Streptococcus pneumoniae strain 4041STDY6836166]
MNKKTRQTLIGLLVLLLLSTGSYYIKQMQSTANSPKTKLSQKKQASEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIV
NGNKTNLDAKVSSKPYADNKTKTVGKETVPTVANALLSKATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGH
LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRVRYRVTLYYASNEDLVPSASQIE
AKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ

Nucleotide

• Length: 825 bp

>NTDB_id=1142084 DQL01_RS10120 WP_001036791.1 1889835..1890659(-) (endA) [Streptococcus pneumoniae strain 4041STDY6836166]
ATGAACAAAAAAACAAGACAGACACTAATCGGACTGCTAGTGTTATTGCTTTTGTCTACAGGGAGCTATTATATCAAGCA
GATGCAGTCGACAGCTAATAGTCCTAAAACCAAGCTTAGTCAGAAAAAACAAGCGTCTGAAGCTCCTAGTCAAGCATTGG
CAGAGAGTGTCTTAACAGACGCAGTCAAGAGTCAAATAAAGGGGAGTCTGGAGTGGAATGGCTCAGGTGCTTTTATCGTC
AATGGTAATAAAACAAATCTAGATGCCAAGGTTTCAAGTAAGCCCTACGCTGACAATAAAACAAAGACAGTGGGCAAGGA
AACTGTTCCAACCGTAGCTAATGCCCTCTTGTCTAAGGCCACTCGTCAGTACAAGAATCGTAAAGAAACTGGGAATGGTT
CAACTTCTTGGACTCCTCCAGGTTGGCATCAGGTCAAGAATCTAAAGGGCTCTTATACCCATGCAGTCGATAGAGGTCAT
TTGTTAGGCTATGCCTTAATCGGTGGTTTGGATGGTTTTGATGCCTCAACAAGCAATCCTAAAAACATTGCTGTTCAGAC
AGCCTGGGCAAATCAGGCACAAGCCGAGTATTCGACTGGTCAAAACTACTATGAAAGCAAGGTGCGTAAAGCTTTGGACC
AAAACAAGCGTGTCCGTTACCGTGTAACCCTTTACTACGCTTCAAACGAGGATTTAGTTCCCTCAGCTTCACAGATTGAA
GCCAAGTCTTCGGATGGAGAATTGGAATTCAATGTTCTAGTTCCCAATGTTCAAAAGGGACTTCAACTGGATTACCGAAC
TGGAGAAGTAACTGTAACTCAGTAA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (75-247)

3D structure

• AlphaFold DB: A0A0B7L7Z9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	98.54	100	0.985
endA	Streptococcus pneumoniae D39	98.54	100	0.985
endA	Streptococcus pneumoniae R6	98.54	100	0.985
endA	Streptococcus pneumoniae TIGR4	98.54	100	0.985