Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   DQM37_RS00695 Genome accession   NZ_LS483394
Coordinates   105671..106624 (+) Length   317 a.a.
NCBI ID   WP_002987790.1    Uniprot ID   A0A5S4TCX5
Organism   Streptococcus pyogenes strain NCTC10880     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 100671..111624
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM37_RS00655 (NCTC10880_00132) - 101498..101863 (+) 366 WP_002986560.1 DUF1033 family protein -
  DQM37_RS00660 (NCTC10880_00133) comYA 101956..102894 (+) 939 WP_023079010.1 competence type IV pilus ATPase ComGA Machinery gene
  DQM37_RS00665 (NCTC10880_00134) comYB 102830..103864 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  DQM37_RS00670 (NCTC10880_00135) comYC 103866..104192 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  DQM37_RS00675 (NCTC10880_00136) comGD 104167..104595 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  DQM37_RS00680 (NCTC10880_00137) comGE 104552..104836 (+) 285 WP_032465969.1 competence type IV pilus minor pilin ComGE -
  DQM37_RS00685 (NCTC10880_00138) comYF 104829..105263 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  DQM37_RS00690 (NCTC10880_00139) comGG 105247..105573 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  DQM37_RS00695 (NCTC10880_00140) comYH 105671..106624 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  DQM37_RS00700 (NCTC10880_00141) - 106683..107879 (+) 1197 WP_011284424.1 acetate kinase -
  DQM37_RS00705 - 108066..108374 (+) 309 Protein_90 hypothetical protein -
  DQM37_RS00710 (NCTC10880_00142) proC 108457..109227 (-) 771 WP_111694636.1 pyrroline-5-carboxylate reductase -
  DQM37_RS00715 (NCTC10880_00143) pepA 109275..110342 (-) 1068 WP_012560390.1 glutamyl aminopeptidase -
  DQM37_RS00725 (NCTC10880_00144) - 110807..111091 (+) 285 WP_002992749.1 DUF4651 domain-containing protein -
  DQM37_RS00730 (NCTC10880_00145) - 111088..111405 (+) 318 WP_002986515.1 thioredoxin family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35985.08 Da        Isoelectric Point: 4.7205

>NTDB_id=1140075 DQM37_RS00695 WP_002987790.1 105671..106624(+) (comYH) [Streptococcus pyogenes strain NCTC10880]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLAPVNLLTSPQ
SQLLKQWLKDYAQVVALITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide


Download         Length: 954 bp        

>NTDB_id=1140075 DQM37_RS00695 WP_002987790.1 105671..106624(+) (comYH) [Streptococcus pyogenes strain NCTC10880]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACT
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGAAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAGATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCCAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACCTGAAAAAAGACGGTTTTGCGATTTTTCTGGCACCAGTCAATTTATTGACGAGCCCTCAG
AGCCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGGCCTTGATTACGCTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(68-288)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TCX5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA159

66.139

99.685

0.659
  comYH Streptococcus mutans UA140

65.823

99.685

0.656

Multiple sequence alignment