Detailed information NTG1137700

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: DQM73_RS04040
• Genome accession: NZ_LS483346
• Coordinates: 776842..777702 (+)
• Length: 286 a.a.
• NCBI ID: WP_002925388.1
• Uniprot ID: A0A2X3VPZ8
• Organism: Streptococcus sanguinis strain NCTC11085
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 771842..782702

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM73_RS04010 (NCTC11085_00779)	-	772099..772980 (+)	882	WP_002895995.1	F0F1 ATP synthase subunit gamma	-
DQM73_RS04015 (NCTC11085_00780)	atpD	773019..774425 (+)	1407	WP_002895993.1	F0F1 ATP synthase subunit beta	-
DQM73_RS04020 (NCTC11085_00781)	-	774433..774855 (+)	423	WP_002900740.1	F0F1 ATP synthase subunit epsilon	-
DQM73_RS04025 (NCTC11085_00782)	-	775030..775260 (+)	231	WP_002895990.1	DUF1146 family protein	-
DQM73_RS04030 (NCTC11085_00783)	murA	775328..776608 (+)	1281	WP_002897900.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
DQM73_RS04035 (NCTC11085_00784)	-	776601..776783 (+)	183	WP_002895988.1	DNA-directed RNA polymerase subunit beta	-
DQM73_RS04040 (NCTC11085_00785)	endA	776842..777702 (+)	861	WP_002925388.1	DNA/RNA non-specific endonuclease	Machinery gene
DQM73_RS04045 (NCTC11085_00786)	-	777880..778599 (+)	720	WP_032908207.1	matrixin family metalloprotease	-
DQM73_RS04050	-	778604..778969 (+)	366	Protein_754	hypothetical protein	-
DQM73_RS04055 (NCTC11085_00788)	-	779069..780964 (+)	1896	WP_032908206.1	ABC-F family ATP-binding cassette domain-containing protein	-
DQM73_RS04060 (NCTC11085_00789)	-	781101..781658 (+)	558	WP_002925381.1	hypothetical protein	-
DQM73_RS04065 (NCTC11085_00790)	-	781804..782535 (+)	732	WP_002912089.1	hypothetical protein	-

Sequence

Protein

• Length: 286 a.a.
• Molecular weight: 31291.01 Da
• Isoelectric Point: 10.1352

>NTDB_id=1137700 DQM73_RS04040 WP_002925388.1 776842..777702(+) (endA) [Streptococcus sanguinis strain NCTC11085]
MKRKTSQKRNSKSLQGWAGLTLALILALAGYFWGQDGQQPLQSPNSEIRVGQVQDQGTPSRELAESVLTEAVRAQLKGSI
EWNGAGAFIVNGNKTDLDAGISSKPYADNKTKFVQGKTLPTVANAFLSKSTRQYKKREETGNANTSWVPAGWHQLKSLPG
EYNHAVDRGHLLAYSLIGGLKGFDASTSNPANIAVQTAWSNQANEADSTGQNYYETKIRKALDKNKRVRYRVTLIYATET
DLVPVGSHLEAKSSDGSLEFNVFIPNVQKGIRLDYNSGRVSLDRGS

Nucleotide

• Length: 861 bp

>NTDB_id=1137700 DQM73_RS04040 WP_002925388.1 776842..777702(+) (endA) [Streptococcus sanguinis strain NCTC11085]
ATGAAAAGAAAGACTAGTCAGAAAAGGAATTCTAAGAGCCTGCAAGGCTGGGCTGGGCTGACTCTGGCCTTGATTTTGGC
GCTGGCTGGCTATTTCTGGGGACAGGATGGTCAGCAGCCACTTCAGAGTCCAAATTCAGAAATCAGAGTTGGGCAAGTCC
AAGATCAGGGCACCCCTAGCCGGGAACTGGCTGAGAGCGTTCTGACGGAAGCTGTCCGAGCTCAGCTCAAAGGCAGCATT
GAATGGAATGGGGCTGGCGCCTTTATCGTGAATGGGAATAAGACAGACTTAGATGCGGGGATTTCTAGTAAGCCCTACGC
TGACAATAAGACCAAGTTTGTTCAAGGGAAAACCCTTCCGACGGTGGCGAATGCCTTTTTATCCAAGTCTACCCGCCAGT
ACAAAAAACGGGAAGAAACTGGAAATGCCAACACTTCATGGGTACCGGCAGGCTGGCATCAACTCAAGAGCCTCCCTGGT
GAGTACAATCATGCTGTGGACCGAGGACATCTCTTGGCCTATTCGCTGATCGGTGGTTTGAAGGGCTTTGATGCCTCCAC
TAGCAATCCTGCCAATATCGCTGTGCAGACGGCCTGGTCCAACCAAGCCAATGAAGCGGATTCGACAGGGCAGAATTACT
ATGAGACAAAGATCCGTAAGGCCCTGGATAAGAACAAGCGGGTGCGCTACCGGGTGACCTTGATTTACGCCACGGAGACG
GATTTAGTACCGGTTGGGTCACATTTAGAGGCTAAGTCCAGCGATGGCAGTTTGGAATTTAATGTCTTTATCCCGAATGT
GCAAAAAGGGATTCGCCTGGACTATAATAGTGGCAGGGTCAGTCTGGATAGAGGTTCTTAA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (89-256)

3D structure

• AlphaFold DB: A0A2X3VPZ8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	73.661	78.322	0.577
endA	Streptococcus pneumoniae D39	73.661	78.322	0.577
endA	Streptococcus pneumoniae R6	73.661	78.322	0.577
endA	Streptococcus pneumoniae TIGR4	73.661	78.322	0.577