Detailed information    

insolico Bioinformatically predicted

Overview

Name   endA   Type   Machinery gene
Locus tag   H1X63_RS05695 Genome accession   NZ_LR822027
Coordinates   1078390..1079271 (-) Length   293 a.a.
NCBI ID   WP_084828863.1    Uniprot ID   A0A0E2QH56
Organism   Streptococcus thermophilus isolate STH_CIRM_998     
Function   cleavage of dsDNA into ssDNA (predicted from homology)   
DNA processing

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 1074184..1078141 1078390..1079271 flank 249


Gene organization within MGE regions


Location: 1074184..1079271
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1X63_RS05665 (STHERMO_1225) - 1074184..1075440 (-) 1257 WP_179971940.1 ISL3 family transposase -
  H1X63_RS05670 (STHERMO_1226) - 1075572..1076048 (-) 477 WP_179971941.1 transposase -
  H1X63_RS11270 - 1076091..1076240 (+) 150 WP_179973008.1 hypothetical protein -
  H1X63_RS05680 - 1076302..1076829 (+) 528 WP_179971942.1 HdeD family acid-resistance protein -
  H1X63_RS10690 (STHERMO_1230) - 1076958..1078215 (-) 1258 Protein_1063 ISL3 family transposase -
  H1X63_RS05695 (STHERMO_1231) endA 1078390..1079271 (-) 882 WP_084828863.1 DNA/RNA non-specific endonuclease Machinery gene

Sequence

Protein


Download         Length: 293 a.a.        Molecular weight: 31768.48 Da        Isoelectric Point: 10.0031

>NTDB_id=1131350 H1X63_RS05695 WP_084828863.1 1078390..1079271(-) (endA) [Streptococcus thermophilus isolate STH_CIRM_998]
MAKGKTSLTNKQKRQFVTLIIAALIAVLGYLGTSNKLSPDNPIRQVASLVSGKSNKSIKSNYLTNSQSTPQEQLAETVMT
SSVKSQLGNSLEWNGAGAYIINGNKTNLNAKVSSQPYANNQVKTVQGQTVPTVANALLSKATRQYKNRQETGNGSTSWTP
AGWHQVQNLSGEYSHAVDRGHLLGYALIGGLKGFDASTSNPENIAVQTAWANQAYSDNSTGQNYYESLVRKALDKNKRVR
YRVTLIYEGENLIPSGTHLEAKSADGSLEFNVFVPNVQEGITLDYYSGKVTVN

Nucleotide


Download         Length: 882 bp        

>NTDB_id=1131350 H1X63_RS05695 WP_084828863.1 1078390..1079271(-) (endA) [Streptococcus thermophilus isolate STH_CIRM_998]
ATGGCAAAAGGAAAAACATCTTTGACAAATAAACAGAAACGTCAGTTCGTCACATTAATAATAGCAGCTTTGATAGCTGT
TTTAGGTTACCTAGGAACCAGCAACAAGCTCTCGCCTGATAATCCTATCAGACAAGTAGCAAGCCTAGTTTCAGGAAAAT
CTAATAAATCCATTAAATCTAATTATTTAACAAATAGTCAGTCTACACCACAAGAGCAGCTTGCTGAGACAGTAATGACT
AGTTCAGTCAAAAGCCAACTGGGTAATTCCTTGGAATGGAATGGAGCTGGAGCCTATATTATTAATGGAAATAAGACGAA
TCTAAATGCTAAGGTATCAAGCCAACCTTATGCTAATAACCAAGTCAAAACGGTTCAAGGACAAACTGTTCCTACAGTTG
CTAATGCCTTATTAAGTAAAGCAACTAGACAGTACAAAAATCGTCAAGAAACAGGGAATGGTTCAACCTCTTGGACACCA
GCTGGATGGCACCAGGTTCAAAATTTATCAGGAGAGTATAGCCATGCCGTAGATAGAGGCCATTTGCTAGGTTATGCACT
GATAGGTGGTTTGAAAGGATTTGATGCCTCGACTTCAAATCCAGAGAATATTGCTGTTCAAACTGCTTGGGCAAATCAAG
CATATAGCGATAATTCTACAGGTCAAAACTATTATGAAAGCCTAGTACGAAAAGCTCTGGATAAAAACAAACGTGTTCGT
TATCGTGTGACCTTGATTTATGAAGGAGAGAACCTCATTCCATCAGGAACACATCTTGAAGCTAAGTCAGCAGACGGATC
ACTTGAGTTTAATGTCTTTGTTCCAAATGTACAAGAGGGAATAACCCTAGATTACTATTCAGGAAAAGTAACGGTGAATT
GA

Domains

Predicted by InterproScan.

DNA/RNA non-specific endonuclease (Endonuclease_NS)

(98-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E2QH56

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  endA Streptococcus pneumoniae Rx1

75.893

76.451

0.58
  endA Streptococcus pneumoniae D39

75.893

76.451

0.58
  endA Streptococcus pneumoniae R6

75.893

76.451

0.58
  endA Streptococcus pneumoniae TIGR4

75.893

76.451

0.58

Multiple sequence alignment