Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   ACE2AN_RS05665 Genome accession   NZ_CP169564
Coordinates   1114393..1115097 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 6_2F1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1109393..1120097
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACE2AN_RS05635 - 1109598..1110584 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  ACE2AN_RS05640 - 1110828..1111604 (-) 777 WP_081528317.1 potassium channel family protein -
  ACE2AN_RS05645 - 1111651..1111905 (-) 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ACE2AN_RS05650 relB 1111907..1112149 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  ACE2AN_RS05655 vicX 1112240..1113049 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  ACE2AN_RS05660 micB 1113051..1114400 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ACE2AN_RS05665 micA 1114393..1115097 (-) 705 WP_000722076.1 response regulator YycF Regulator
  ACE2AN_RS05670 mutY 1115152..1116327 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  ACE2AN_RS05675 - 1116424..1116549 (+) 126 WP_001818232.1 hypothetical protein -
  ACE2AN_RS05680 - 1116655..1118325 (-) 1671 WP_081528316.1 formate--tetrahydrofolate ligase -
  ACE2AN_RS05685 coaB 1118555..1119244 (+) 690 WP_000699503.1 phosphopantothenate--cysteine ligase -
  ACE2AN_RS05690 coaC 1119256..1119807 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=1052183 ACE2AN_RS05665 WP_000722076.1 1114393..1115097(-) (micA) [Streptococcus pneumoniae strain 6_2F1]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=1052183 ACE2AN_RS05665 WP_000722076.1 1114393..1115097(-) (micA) [Streptococcus pneumoniae strain 6_2F1]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCACGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment