Detailed information    

insolico Bioinformatically predicted

Overview

Name   codY   Type   Regulator
Locus tag   DQN35_RS02005 Genome accession   NZ_LS483442
Coordinates   378015..378797 (+) Length   260 a.a.
NCBI ID   WP_002983278.1    Uniprot ID   A2RCV3
Organism   Streptococcus pyogenes strain NCTC8370     
Function   repress the expression of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 373015..383797
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN35_RS01985 (NCTC8370_00394) - 373352..374317 (-) 966 WP_011285687.1 asparaginase -
  DQN35_RS01990 (NCTC8370_00395) - 374389..375777 (+) 1389 WP_010922607.1 Cof-type HAD-IIB family hydrolase -
  DQN35_RS01995 (NCTC8370_00396) - 375900..376352 (-) 453 WP_002992571.1 universal stress protein -
  DQN35_RS02000 (NCTC8370_00397) - 376583..377797 (+) 1215 WP_010922605.1 pyridoxal phosphate-dependent aminotransferase -
  DQN35_RS02005 (NCTC8370_00398) codY 378015..378797 (+) 783 WP_002983278.1 GTP-sensing pleiotropic transcriptional regulator CodY Regulator
  DQN35_RS02010 (NCTC8370_00399) - 378944..379498 (+) 555 WP_010922604.1 cysteine hydrolase family protein -
  DQN35_RS02020 - 380037..380261 (+) 225 WP_002988560.1 putative PEP-binding protein -
  DQN35_RS02025 (NCTC8370_00400) gatC 380493..380795 (+) 303 WP_002988561.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
  DQN35_RS02030 (NCTC8370_00401) gatA 380795..382261 (+) 1467 WP_011285681.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
  DQN35_RS02035 (NCTC8370_00402) gatB 382261..383700 (+) 1440 WP_010922602.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -

Sequence

Protein


Download         Length: 260 a.a.        Molecular weight: 28633.76 Da        Isoelectric Point: 4.5611

>NTDB_id=1024962 DQN35_RS02005 WP_002983278.1 378015..378797(+) (codY) [Streptococcus pyogenes strain NCTC8370]
MPNLLEKTRKITSILQRSVDSLETELPYNTMASRLADIIDCNACIINGGGTLLGYAMKYKTNTDRVEEFFEAKQFPDTYV
KAASRVYDTEANLSVENELTIFPVESKDTYPGGLTTIAPIYGGGMRLGSLIIWRNDNEFSDDDLILVEISSTVVGIQLLN
LQTENLEDTIRKQTAVNMAINTLSYSEMKAVAAILGELDGNEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVINEGIFAKLKEF

Nucleotide


Download         Length: 783 bp        

>NTDB_id=1024962 DQN35_RS02005 WP_002983278.1 378015..378797(+) (codY) [Streptococcus pyogenes strain NCTC8370]
ATGCCTAACTTATTAGAAAAAACTCGTAAAATCACATCTATTTTGCAGCGTTCCGTAGATAGCCTAGAAACAGAATTACC
GTATAACACAATGGCATCTCGCCTAGCAGATATCATTGACTGCAATGCTTGTATTATCAATGGCGGCGGCACACTGCTTG
GTTATGCCATGAAATATAAAACTAACACTGATCGTGTTGAGGAATTTTTTGAAGCTAAACAATTTCCAGATACTTATGTA
AAGGCTGCTAGCCGAGTTTACGATACAGAAGCTAACCTTTCTGTCGAAAATGAATTGACTATATTCCCTGTTGAGTCTAA
AGACACTTATCCAGGAGGTCTAACGACTATTGCGCCGATTTATGGTGGAGGGATGCGCCTTGGATCACTCATTATCTGGC
GTAATGACAATGAGTTTAGTGATGATGATTTGATTTTGGTTGAGATCTCAAGTACTGTTGTGGGGATTCAACTATTAAAT
CTTCAGACAGAAAACTTAGAAGACACCATCCGTAAACAAACAGCGGTCAACATGGCAATTAATACGCTTTCTTATTCAGA
AATGAAAGCTGTTGCAGCAATTCTTGGAGAGTTAGATGGTAACGAAGGACGATTGACAGCTTCTGTTATTGCTGATCGTA
TTGGTATTACCCGTTCTGTTATTGTCAATGCTCTGCGTAAACTAGAAAGTGCAGGGATTATTGAAAGTCGTTCTCTTGGT
ATGAAAGGGACATACCTCAAAGTTATCAACGAAGGTATTTTTGCTAAATTAAAAGAATTTTAA

Domains

Predicted by InterProScan.

CodY helix-turn-helix domain (HTH_CodY)

(202-260)

CodY GAF-like domain (CodY)

(3-182)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A2RCV3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  codY Lactococcus lactis subsp. lactis strain DGCC12653

66.148

98.846

0.654
  codY Bacillus subtilis subsp. subtilis str. 168

51.373

98.077

0.504

Multiple sequence alignment