Detailed information NTG1012142

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H1W81_RS03140
• Genome accession: NZ_LR824002
• Coordinates: 590238..591023 (+)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_67
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 585238..596023

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W81_RS03110 (STHERMO_0674)	pflA	585514..586314 (+)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-
H1W81_RS03115 (STHERMO_0675)	-	586526..586900 (+)	375	WP_041828320.1	membrane protein	-
H1W81_RS03120 (STHERMO_0676)	-	586961..587134 (+)	174	WP_011681546.1	hypothetical protein	-
H1W81_RS03125	-	587206..587777 (-)	572	Protein_561	IS30 family transposase	-
H1W81_RS03130 (STHERMO_0679)	-	587957..588409 (-)	453	WP_002946987.1	universal stress protein	-
H1W81_RS03135 (STHERMO_0680)	-	588764..589978 (+)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
H1W81_RS03140 (STHERMO_0681)	codY	590238..591023 (+)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H1W81_RS03145 (STHERMO_0682)	-	591086..591637 (+)	552	WP_179971648.1	cysteine hydrolase family protein	-
H1W81_RS03150 (STHERMO_0683)	-	591760..592608 (+)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H1W81_RS03155 (STHERMO_0684)	msrA	592620..593129 (+)	510	WP_002951714.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H1W81_RS03160 (STHERMO_0685)	-	593282..594728 (+)	1447	Protein_568	6-phospho-beta-glucosidase	-
H1W81_RS03165 (STHERMO_0687)	-	595092..595253 (+)	162	WP_180473551.1	glycosyltransferase	-
H1W81_RS03170 (STHERMO_0688)	-	595266..595520 (+)	255	WP_011226449.1	glycosyl transferase	-
H1W81_RS03175 (STHERMO_0689)	gatC	595660..595962 (+)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1012142 H1W81_RS03140 WP_002951720.1 590238..591023(+) (codY) [Streptococcus thermophilus isolate STH_CIRM_67]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1012142 H1W81_RS03140 WP_002951720.1 590238..591023(+) (codY) [Streptococcus thermophilus isolate STH_CIRM_67]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502