Detailed information NTG1011482

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H1W92_RS07695
• Genome accession: NZ_LR822039
• Coordinates: 1462053..1462838 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_1116
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1457053..1467838

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W92_RS07660 (STHERMO_1669)	gatC	1457119..1457421 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
H1W92_RS07665 (STHERMO_1670)	-	1457561..1457815 (-)	255	WP_011226449.1	glycosyl transferase	-
H1W92_RS07670 (STHERMO_1671)	-	1457828..1458037 (-)	210	WP_011226450.1	glycosyltransferase	-
H1W92_RS07675	-	1458353..1459794 (-)	1442	Protein_1452	6-phospho-beta-glucosidase	-
H1W92_RS07680 (STHERMO_1674)	msrA	1459947..1460456 (-)	510	WP_002946589.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H1W92_RS07685 (STHERMO_1675)	-	1460468..1461316 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H1W92_RS07690 (STHERMO_1676)	-	1461439..1461990 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
H1W92_RS07695 (STHERMO_1677)	codY	1462053..1462838 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H1W92_RS07700 (STHERMO_1678)	-	1463098..1464312 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
H1W92_RS07705 (STHERMO_1679)	-	1464693..1465145 (+)	453	WP_002946987.1	universal stress protein	-
H1W92_RS07710	-	1465325..1465896 (+)	572	Protein_1459	IS30 family transposase	-
H1W92_RS07715 (STHERMO_1683)	-	1466112..1466582 (-)	471	WP_011227497.1	membrane protein	-
H1W92_RS07720 (STHERMO_1685)	pflA	1466788..1467588 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1011482 H1W92_RS07695 WP_002951720.1 1462053..1462838(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_1116]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1011482 H1W92_RS07695 WP_002951720.1 1462053..1462838(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_1116]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502