Detailed information NTG1010959

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H1W90_RS07855
• Genome accession: NZ_LR822033
• Coordinates: 1520604..1521389 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_1048
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1515604..1526389

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W90_RS07820 (STHERMO_1742)	gatC	1515671..1515973 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
H1W90_RS07825 (STHERMO_1743)	-	1516113..1516367 (-)	255	WP_180481089.1	glycosyltransferase	-
H1W90_RS07830 (STHERMO_1744)	-	1516380..1516589 (-)	210	WP_180481090.1	glycosyltransferase	-
H1W90_RS07835 (STHERMO_1745)	-	1516905..1518345 (-)	1441	Protein_1514	6-phospho-beta-glucosidase	-
H1W90_RS07840 (STHERMO_1747)	msrA	1518498..1519007 (-)	510	WP_002951714.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H1W90_RS07845 (STHERMO_1748)	-	1519019..1519867 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H1W90_RS07850 (STHERMO_1749)	-	1519990..1520541 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
H1W90_RS07855 (STHERMO_1750)	codY	1520604..1521389 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H1W90_RS07860 (STHERMO_1751)	-	1521649..1522863 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
H1W90_RS07865 (STHERMO_1752)	-	1523218..1523670 (+)	453	WP_002946987.1	universal stress protein	-
H1W90_RS07870	-	1523847..1524421 (+)	575	Protein_1521	IS30 family transposase	-
H1W90_RS10140 (STHERMO_1755)	-	1524493..1525101 (-)	609	WP_002946982.1	hypothetical protein	-
H1W90_RS07880 (STHERMO_1757)	pflA	1525313..1526113 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1010959 H1W90_RS07855 WP_002951720.1 1520604..1521389(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_1048]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1010959 H1W90_RS07855 WP_002951720.1 1520604..1521389(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_1048]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502