Detailed information NTG1010850

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H1W91_RS07830
• Genome accession: NZ_LR822032
• Coordinates: 1498744..1499529 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_1050
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1493744..1504529

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W91_RS07795 (STHERMO_1704)	gatC	1493811..1494113 (-)	303	WP_180477134.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
H1W91_RS07800 (STHERMO_1705)	-	1494252..1494506 (-)	255	WP_041827766.1	glycosyl transferase	-
H1W91_RS07805 (STHERMO_1706)	-	1494519..1494728 (-)	210	WP_011226450.1	glycosyltransferase	-
H1W91_RS07810 (STHERMO_1707)	-	1495044..1496485 (-)	1442	Protein_1485	6-phospho-beta-glucosidase	-
H1W91_RS07815 (STHERMO_1708)	msrA	1496638..1497147 (-)	510	WP_180473319.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H1W91_RS07820 (STHERMO_1709)	-	1497159..1498007 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H1W91_RS07825 (STHERMO_1710)	-	1498130..1498681 (-)	552	WP_173940634.1	cysteine hydrolase family protein	-
H1W91_RS07830 (STHERMO_1711)	codY	1498744..1499529 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H1W91_RS07835 (STHERMO_1712)	-	1499789..1501003 (-)	1215	WP_180477135.1	pyridoxal phosphate-dependent aminotransferase	-
H1W91_RS07840 (STHERMO_1713)	-	1501358..1501810 (+)	453	WP_180477136.1	universal stress protein	-
H1W91_RS10140	-	1501990..1502561 (+)	572	Protein_1492	IS30 family transposase	-
H1W91_RS07845 (STHERMO_1716)	-	1502633..1502806 (-)	174	WP_011681546.1	hypothetical protein	-
H1W91_RS07850 (STHERMO_1717)	-	1502867..1503241 (-)	375	WP_011681547.1	membrane protein	-
H1W91_RS07855 (STHERMO_1718)	pflA	1503453..1504253 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1010850 H1W91_RS07830 WP_002951720.1 1498744..1499529(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_1050]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1010850 H1W91_RS07830 WP_002951720.1 1498744..1499529(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_1050]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACGGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATCACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502