Detailed information NTG1010743

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H1W74_RS07405
• Genome accession: NZ_LR822031
• Coordinates: 1435800..1436585 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_1047
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1430800..1441585

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W74_RS07370 (STHERMO_1670)	gatC	1430866..1431168 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
H1W74_RS07375 (STHERMO_1671)	-	1431308..1431562 (-)	255	WP_011226449.1	glycosyl transferase	-
H1W74_RS07380 (STHERMO_1672)	-	1431575..1431784 (-)	210	WP_011226450.1	glycosyltransferase	-
H1W74_RS07385 (STHERMO_1673)	-	1432100..1433541 (-)	1442	Protein_1417	6-phospho-beta-glucosidase	-
H1W74_RS07390 (STHERMO_1674)	msrA	1433694..1434203 (-)	510	WP_002946589.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H1W74_RS07395 (STHERMO_1675)	-	1434215..1435063 (-)	849	WP_022096458.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H1W74_RS07400 (STHERMO_1676)	-	1435186..1435737 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
H1W74_RS07405 (STHERMO_1677)	codY	1435800..1436585 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H1W74_RS07410 (STHERMO_1678)	-	1436845..1438059 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
H1W74_RS07415 (STHERMO_1679)	-	1438414..1438866 (+)	453	WP_002946987.1	universal stress protein	-
H1W74_RS09860	-	1439043..1439617 (+)	575	Protein_1424	IS30 family transposase	-
H1W74_RS09865 (STHERMO_1682)	-	1439689..1440297 (-)	609	WP_002946982.1	hypothetical protein	-
H1W74_RS07425 (STHERMO_1683)	pflA	1440509..1441309 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1010743 H1W74_RS07405 WP_002951720.1 1435800..1436585(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_1047]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1010743 H1W74_RS07405 WP_002951720.1 1435800..1436585(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_1047]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502