Detailed information NTG1010639

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H1W95_RS07780
• Genome accession: NZ_LR822030
• Coordinates: 1513555..1514340 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_1046
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1508555..1519340

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W95_RS07745 (STHERMO_1741)	gatC	1508619..1508921 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
H1W95_RS07750	-	1509096..1509314 (-)	219	WP_014621899.1	glycosyl transferase	-
H1W95_RS10315 (STHERMO_1743)	-	1509253..1509417 (-)	165	WP_231838381.1	glycosyltransferase	-
H1W95_RS07760 (STHERMO_1744)	-	1509854..1511295 (-)	1442	Protein_1493	6-phospho-beta-glucosidase	-
H1W95_RS07765 (STHERMO_1745)	msrA	1511448..1511957 (-)	510	WP_041829085.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H1W95_RS07770 (STHERMO_1746)	-	1511969..1512817 (-)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H1W95_RS07775 (STHERMO_1747)	-	1512941..1513492 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
H1W95_RS07780 (STHERMO_1748)	codY	1513555..1514340 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H1W95_RS07785 (STHERMO_1749)	-	1514600..1515814 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
H1W95_RS07790 (STHERMO_1750)	-	1516169..1516621 (+)	453	WP_002946987.1	universal stress protein	-
H1W95_RS10320	-	1516801..1517372 (+)	572	Protein_1500	IS30 family transposase	-
H1W95_RS07795 (STHERMO_1753)	-	1517444..1517617 (-)	174	WP_014621904.1	hypothetical protein	-
H1W95_RS07800 (STHERMO_1754)	-	1517684..1518052 (-)	369	WP_014621905.1	membrane protein	-
H1W95_RS07805 (STHERMO_1755)	pflA	1518264..1519064 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1010639 H1W95_RS07780 WP_002951720.1 1513555..1514340(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_1046]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1010639 H1W95_RS07780 WP_002951720.1 1513555..1514340(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_1046]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502