Detailed information NTG1009879

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H0510_RS07455
• Genome accession: NZ_LR822019
• Coordinates: 1428995..1429780 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_772
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1423995..1434780

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0510_RS07420 (STHERMO_1639)	gatC	1424060..1424362 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
H0510_RS09670 (STHERMO_1640)	-	1424502..1424663 (-)	162	WP_224103235.1	hypothetical protein	-
H0510_RS09675 (STHERMO_1641)	-	1424695..1424967 (-)	273	WP_224103183.1	glycosyltransferase	-
H0510_RS07435 (STHERMO_1642)	-	1425294..1426735 (-)	1442	Protein_1427	6-phospho-beta-glucosidase	-
H0510_RS07440 (STHERMO_1643)	msrA	1426888..1427397 (-)	510	WP_041829085.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H0510_RS07445 (STHERMO_1644)	-	1427409..1428257 (-)	849	WP_179967094.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H0510_RS07450 (STHERMO_1645)	-	1428381..1428932 (-)	552	WP_173940634.1	cysteine hydrolase family protein	-
H0510_RS07455 (STHERMO_1646)	codY	1428995..1429780 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H0510_RS07460 (STHERMO_1647)	-	1430040..1431254 (-)	1215	WP_179966774.1	pyridoxal phosphate-dependent aminotransferase	-
H0510_RS07465 (STHERMO_1648)	-	1431609..1432061 (+)	453	WP_164178276.1	universal stress protein	-
H0510_RS09680	-	1432241..1432812 (+)	572	Protein_1434	IS30 family transposase	-
H0510_RS09685 (STHERMO_1651)	-	1432884..1433480 (-)	597	WP_232086461.1	hypothetical protein	-
H0510_RS07475 (STHERMO_1652)	pflA	1433692..1434492 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1009879 H0510_RS07455 WP_002951720.1 1428995..1429780(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_772]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1009879 H0510_RS07455 WP_002951720.1 1428995..1429780(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_772]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATCACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502