Detailed information NTG1009573

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H0508_RS07380
• Genome accession: NZ_LR822014
• Coordinates: 1432996..1433781 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_36
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1427996..1438781

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0508_RS07345 (STHERMO_1634)	gatC	1428057..1428359 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
H0508_RS07350 (STHERMO_1635)	-	1428499..1428753 (-)	255	WP_011226449.1	glycosyl transferase	-
H0508_RS07355 (STHERMO_1636)	-	1428766..1428975 (-)	210	WP_011226450.1	glycosyltransferase	-
H0508_RS07360 (STHERMO_1638)	-	1429291..1430737 (-)	1447	Protein_1408	6-phospho-beta-glucosidase	-
H0508_RS07365 (STHERMO_1639)	msrA	1430890..1431399 (-)	510	WP_002951714.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H0508_RS07370 (STHERMO_1640)	-	1431411..1432259 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H0508_RS07375 (STHERMO_1641)	-	1432382..1432933 (-)	552	WP_179971648.1	cysteine hydrolase family protein	-
H0508_RS07380 (STHERMO_1642)	codY	1432996..1433781 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H0508_RS07385 (STHERMO_1643)	-	1434041..1435255 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
H0508_RS07390 (STHERMO_1644)	-	1435610..1436062 (+)	453	WP_002946987.1	universal stress protein	-
H0508_RS07395	-	1436242..1436813 (+)	572	Protein_1415	IS30 family transposase	-
H0508_RS07400 (STHERMO_1647)	-	1436885..1437058 (-)	174	WP_011681546.1	hypothetical protein	-
H0508_RS07405 (STHERMO_1648)	-	1437119..1437493 (-)	375	WP_041828320.1	membrane protein	-
H0508_RS07410 (STHERMO_1649)	pflA	1437705..1438505 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1009573 H0508_RS07380 WP_002951720.1 1432996..1433781(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_36]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1009573 H0508_RS07380 WP_002951720.1 1432996..1433781(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_36]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502