Detailed information NTG1009367

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H0505_RS07475
• Genome accession: NZ_LR822012
• Coordinates: 1447262..1448047 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_30
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1442262..1453047

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0505_RS07445 (STHERMO_1639)	gatC	1442326..1442628 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
H0505_RS07450 (STHERMO_1641)	-	1442961..1443233 (-)	273	WP_232085675.1	glycosyltransferase	-
H0505_RS07455 (STHERMO_1642)	-	1443561..1445002 (-)	1442	Protein_1426	6-phospho-beta-glucosidase	-
H0505_RS07460 (STHERMO_1643)	msrA	1445155..1445664 (-)	510	WP_002951714.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H0505_RS07465 (STHERMO_1644)	-	1445676..1446524 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H0505_RS07470 (STHERMO_1645)	-	1446648..1447199 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
H0505_RS07475 (STHERMO_1646)	codY	1447262..1448047 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H0505_RS07480 (STHERMO_1647)	-	1448307..1449521 (-)	1215	WP_179971028.1	pyridoxal phosphate-dependent aminotransferase	-
H0505_RS07485 (STHERMO_1648)	-	1449876..1450328 (+)	453	WP_002946987.1	universal stress protein	-
H0505_RS09865	-	1450505..1451079 (+)	575	Protein_1433	IS30 family transposase	-
H0505_RS07490 (STHERMO_1651)	-	1451151..1451324 (-)	174	WP_011681546.1	hypothetical protein	-
H0505_RS07495 (STHERMO_1652)	-	1451385..1451759 (-)	375	WP_179971375.1	hypothetical protein	-
H0505_RS07500 (STHERMO_1654)	pflA	1451971..1452771 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1009367 H0505_RS07475 WP_002951720.1 1447262..1448047(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_30]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1009367 H0505_RS07475 WP_002951720.1 1447262..1448047(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_30]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATCACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502