Detailed information NTG1009212

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H0504_RS01540
• Genome accession: NZ_LR822011
• Coordinates: 295402..296187 (+)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_23
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 290402..301187

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0504_RS01515 (STHERMO_0320)	pflA	290678..291478 (+)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-
H0504_RS01520 (STHERMO_0321)	-	291690..292064 (+)	375	WP_041828320.1	membrane protein	-
H0504_RS01525 (STHERMO_0322)	-	292125..292298 (+)	174	WP_011681546.1	hypothetical protein	-
H0504_RS09450	-	292370..292941 (-)	572	Protein_262	IS30 family transposase	-
H0504_RS01530 (STHERMO_0325)	-	293121..293573 (-)	453	WP_002946987.1	universal stress protein	-
H0504_RS01535 (STHERMO_0326)	-	293928..295142 (+)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
H0504_RS01540 (STHERMO_0327)	codY	295402..296187 (+)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H0504_RS01545 (STHERMO_0328)	-	296250..296801 (+)	552	WP_179971648.1	cysteine hydrolase family protein	-
H0504_RS01550 (STHERMO_0329)	-	296924..297772 (+)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H0504_RS01555 (STHERMO_0330)	msrA	297784..298293 (+)	510	WP_002951714.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H0504_RS01560 (STHERMO_0331)	-	298446..299887 (+)	1442	Protein_269	6-phospho-beta-glucosidase	-
H0504_RS01565 (STHERMO_0332)	-	300215..300412 (+)	198	WP_231108739.1	glycosyltransferase	-
H0504_RS01570 (STHERMO_0333)	-	300425..300679 (+)	255	WP_011226449.1	glycosyl transferase	-
H0504_RS01575 (STHERMO_0334)	gatC	300819..301121 (+)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1009212 H0504_RS01540 WP_002951720.1 295402..296187(+) (codY) [Streptococcus thermophilus isolate STH_CIRM_23]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1009212 H0504_RS01540 WP_002951720.1 295402..296187(+) (codY) [Streptococcus thermophilus isolate STH_CIRM_23]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502